Background: Exhaled nitric oxide (eNO) is a noninvasive marker of airway inflammation that has been used in children, using the "offline" technique. To the extent of our knowledge, no article reported in literature compares the concordance and correlation between the two different technologies used to measure eNO at tidal volume offline. This study aimed to report the concordance and correlation of the eNO measured "offline" at tidal volume, using chemioluminiscence (cl) vs electrochemical devices (eq). Methods: A cross-sectional, observational, and prospective study was conducted in the National Institute of Respiratory Diseases (Instituto Nacional de Enfermedades Respiratorias), Mexico City. Healthy children and those with a lung disease between 1 and 11 years of age were included. The exhaled air sample at tidal volume was obtained by attaching a mask connected to a Mylar® bag. Results: We studied 36 children. The mean ± standard deviation (SD) age of the study population was 6 ± 2.6 years; 25% of the subjects included were healthy, and the rest had a lung disease. The concordance correlation coefficient between the two measuring devices was 0.98 (p < 0.001), with a mean difference of 1.46 ± 3.5 ppb and 95% limits of agreement from -5.3 ppb to 8.3 ppb. The linear regression model equation for the estimation of eNO was eNO cl = (eNO eq •1.0718) -0.1343 (r 2 = 0.97). Conclusions: The measurement of eNO at tidal volume by the offline method can be analyzed by electrochemical devices, and the results are interchangeable with those analyzed by chemiluminescence technology.
Background: Exhaled nitric oxide (eNO) is a noninvasive marker of airway inflammation that can be measured by the "online" or "offline" technique. There are few articles that measure "offline" eNO in children at tidal volume and to our knowledge there is no article that compares the concordance and correlation between 2 different technologies measured offline at tidal volume. Objective: is to report the concordance and correlation of the eNO results obtained with a chemiluminescence vs. an electrochemical device by the "offline" technique at tidal volume. Methods: A cross-sectional, observational and prospective study was conducted in the National Institute of Respiratory Diseases, Mexico City. Healthy children and those with any lung disease between 1 and 11 years of age were included. The exhaled air sample was obtained at tidal volume by attaching a mask with a connection to a Mylar® bag. Results: 36 children were studied. The average (±SD) age of the study population was 6 ± 2.6 years; 25% of subjects included were healthy, and the rest had lung disease. The concordance correlation coefficient between the two measuring devices was 0.98 (p<0.001), with an average difference of 1.46 ± 3.5 ppb and 95% limits of agreement from-5.3 ppb to 8.3 ppb. The linear regression model equation for the estimation of eNO was eNO,cl = (eNO,eq• 1.0718)-0.1343, (r2 = 0.97) Conclusion: The measurement of eNO by the "offline" method at tidal volume can be analyzed by electrochemical devices, and the results are interchangeable with those analyzed by chemiluminescence technology.
Las infecciones respiratorias agudas son causa de alta morbi-mortalidad a nivel mundial. El Coronavirus descubierto en Wuhan, China en el 2019 es de interés mundial por las diferentes manifestaciones clínicas que pueden aparecer en niños. Nuestro objetivo principal es revisar las manifestaciones del COVID-19 en el aparato respiratorio y los hallazgos a nivel radiológicos en pediatría. Se estiman que solo el 5,7% de los niños han sido hospitalizados, siendo los niños con comorbilidades y menores de 1 año los que suponen un riesgo mayor para enfermedad grave. A nivel global la mediana de edad de presentación de los casos es alrededor de 7 años, detectándose más casos a mayor edad, pero siendo la gravedad inversamente proporcional a la edad. La forma asintomática o leve son las presentaciones más comunes reportadas en niños, siendo de hasta en el 90% de los niños infectados. Los estudios de laboratorio pueden ser normales o presentar leucocitos alterados en un 69,2% y a nivel radiológico se ha observado en niños que en un 69% presentan opacidades bilaterales en vidrio despulido. En este momento, cualquier infección respiratoria aguda hay que descartar COVID-19, para poder evitar complicaciones en el paciente.
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