Paclitaxel nanosuspensions for targeted chemotherapy – nanosuspension preparation, characterization, and use

Abstract

The paclitaxel nanosuspension is suitable for cellular uptake. The nanosuspension was effective in prolonging life in two separate xenograft orthotopic murine cancer models through two separate routes of administration.

Preparation and characterization of paclitaxel nanosuspension using novel emulsification method by combining high speed homogenizer and high pressure homogenization

“…It had been shown that emulsification method which recurred to a coalition between high speed homogenizer and HPH, could be used to formulate PTXNS in the nanometer range and succeeded in gaining cost-effective and technically simple advantages compared with the previous preparation of PTXNS (Lee et al, 2013;Wang et al, 2011). In this study, single-factor method was used to optimize procedure.…”

“…It has been reported that Lee et al (2013) and Wang et al (2011) used HPH to prepare PTX nanosuspension (PTXNS). However, the preparation methods in the two literatures were found to be equipped with the following disadvantages.…”

Wet Media Milling: An Effective Way to Solve Drug Solubility Issue

“…In another study, coated paclitaxel nanosuspensions prepared by HPH technique was evaluated for their cellular uptake and for targeting potential in tumor-bearing mouse models. All the nanosuspensions prolonged the mouse survival time at reduced dose in two different xenograft orthotopic murine cancer models when administered by two different routes [13].…”

Developing Nanocrystals for Cancer Treatment

“…Surface treatment can also be utilized to render nanocrystals with enhanced pharmacokinetic properties. For example, biodistribution of nanocrystals may be further regulated by surface modification with hydrophilic materials to prolong the blood circulation; cancer-targeting ligands may be used to enhance drug accumulation in the tumor [30][31][32]. In addition, coated nanocrystals can reduce multidrug resistance (MDR) [33][34][35].…”

“…Because of the advantages of using nanocrystals over conventional delivery systems, an increasing number of anticancer drugs have been formulated into nanocrystals for intravenous delivery (Table 2) [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. As expected for the array of agents examined, various types of cancers, including pancreatic, stomach, lung and prostate, have being studied with the treatment of nanocrystals.…”