Wet Media Milling: An Effective Way to Solve Drug Solubility Issue

Abstract

Drug synthesis, high-throughput screening generates billions of poorly soluble drugs which are neglected in further developments due to solubility issues. In the last 20 years, nanonization by milling is being effectively used commercially to save these drugs by overcoming solubility problems in commercial way. Various labs at industry and academic level successfully investigated milling technique alone and in combination with other techniques to reduce particle size, thereby increasing the dissolution velocity of drug. Milling offers ease of production, efficient control of production parameters, freedom of small to industrial batch size, liberty to produce highly concentrated suspensions, and improved stability of final product. Nanonized slurries exhibited promising results in vitro and in vivo and many fold increase in bioavailability. Nanosuspensions are investigated for organ or cellular delivery in various diseases like HIV/AIDS, malaria, and other infectious disease conditions. The issue of metal abrasion and contamination is now nullified by effective engineering solutions. In this chapter, recent updates on milling techniques and their applications in pharmaceutical field are discussed.

Current hurdles to the translation of nanomedicines from bench to the clinic

“…The manufacturing of nanomedicines generally uses one of two approaches, either "top-down" or "bottom-up" (Fig. 1) [89][90][91].…”