Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency

Zhang, Zongrui; Wang, Xinyu; Li, Binbin; Hou, Yuanjing; Cai, Zhengwei; Yang, Jing; Li, Yi

doi:10.1039/c7ra12683b

Cited by 46 publications

(36 citation statements)

References 55 publications

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“…The FTIR spectra of free thymol displayed characteristic peaks at 2873, 1622, 1587, and 1285 cm −1 , corresponding to anti-symmetric deformation of –CH 3 , stretching vibration of C=C, bending deformation of –CH 3 , and stretching vibration of C–O [20]. Major peaks ascribed to PLGA were observed at 1755 (C=O bending deformation) and 1088 cm −1 (C–O–C stretching) [15]. The FTIR spectra of thymol-loaded PLGA microparticles displayed both thymol and PLGA peaks at 2862, 1756, 1619, 1280, and 1094 cm −1 with minor shifts in wavenumber.…”

Section: Resultsmentioning

confidence: 99%

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Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

et al. 2019

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Thymol has been shown to be a safe and effective broad-spectrum antimicrobial agent that can be used as a food preservative. However, its volatile characteristics and strong odor limit its use in food products. The microencapsulation of this essential oil in biopolymers could overcome these disadvantages. In this work, thymol-loaded poly(lactide-co-glycolide) (PLGA) microparticles were successfully prepared and the optimal encapsulation efficiency was obtained at 20% (w/w) thymol. Microparticles containing thymol presented a spherical shape and smooth surface. Microencapsulation significantly improved the thermal and storage stability of thymol. In vitro release profiles demonstrated an initial fast release followed by a slow and sustained release. Thymol-loaded microparticles had strong antibacterial activity against Escherichia coli and Staphylococcus aureus, and the effectiveness of their antibacterial properties was confirmed in a milk test. Therefore, the thymol-loaded microparticles show great potential for use as an antimicrobial and as preservation additives in food.

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Section: Resultsmentioning

confidence: 99%

“…The release profiles of thymol-loaded PLGA microparticles in solution were analyzed spectrophotometrically as described by Zhang et al [15]. Briefly, 40 mg of microparticles were dissolved into 40 mL phosphate buffer solution (PBS, 0.15 M, pH 7.4) with 1% Tween-80.…”

Section: Methodsmentioning

confidence: 99%

Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

et al. 2019

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“…Furthermore, Figure (c) reveals the major 2θ values of 27.76°, 28.94°, and 23.19° and it also introduces half‐crystalline nature which indicate the entrapped/encapsulation of LO and PTX component on polymeric micelle.Zhang et al., proposed PTX‐loaded PLGA microspheres also indicates good anti‐tumor efficiency. The free PTX was crystalline in nature after the drug was encapsulated on polymeric microspheres and then crystalline nature was reduced to semi‐crystalline nature of the compounds as it was readily diffused and drug was released fast at the release of tumor site …”

Section: Resultsmentioning

confidence: 99%

Dual Role of Lanthanum Oxide Nanoparticles Functionalized Co‐Polymeric Micelle for Extended Anti‐Cancer Drug Delivery

et al. 2019

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In this study, the paclitaxel (PTX) ‐ loaded A−B type di‐block polymeric micelles poly xylitol sebacate‐poly methylmethacrylic acid/Lanthanum Oxide/paclitaxel (PXS‐PMAA/LO/PTX) were designed and Lanthanum oxide nanoparticles were tagged on the surface of the micelle for the improvement of the antitumor drug efficiency in the cancer cells. LO nanoparticles influence the formation of sphere‐shaped micelles and production of reactive oxygen species (ROS) to inhibite the cancer.Then, in‐vitro drug release of PTX was carried out by UV‐Vis spectroscopy and it was examined for pH depended drug releases. Cell uptake of the PTX‐loaded micelles was investigated in human norml cell VERO and A549 cell line. The cytotoxicity study reveals that the PTX‐loaded polymeric nano micelle has higher efficacy compared to free PTX. Living cell, cell apoptosis, ROS production and nuclear morphological changes were analyzed through Acridine Orange/Ethidium Bromide dual stain, cationic probe rhodamine 123, 2,7‐dichlorofluorescene and Hoechst 33342 staining respectively. Hence, the PTX‐loaded PXS‐PMAA/LO carrier can act as potential drug carrier for cancer treatment.

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“…[56] Until now, systematic studies have only been performed with elongated particles, in particular rod-like filomicelles, which will therefore be the main topic of discussion in the section 4 and 5. [56] Until now, systematic studies have only been performed with elongated particles, in particular rod-like filomicelles, which will therefore be the main topic of discussion in the section 4 and 5.…”

Section: Influence Of Shapes Of Nanoparticles On Their Anticancer Effmentioning

confidence: 99%

“…Discoidal porous silica nanoparticles demonstrated a fivefold increased accumulation in breast tumor mass . Formation of PLGA nanoparticles demonstrating porous matrix and rough surface showed increased in vivo antitumor efficacy compared to nonporous, smooth PLGA particles, owing to their high drug loading and high dispersion in tumor sites . Until now, systematic studies have only been performed with elongated particles, in particular rod‐like filomicelles, which will therefore be the main topic of discussion in the section 4 and 5.…”

Section: Influence Of Shapes Of Nanoparticles On Their Anticancer Effmentioning

confidence: 99%

Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

Pijpers

Abdelmohsen

Xia

et al. 2018

Advanced Therapeutics

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Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well-defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof-of-concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.

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Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency

Abstract: A novel morphological PTX-PLGA-MS with microporous surface and porous internal structures to enhance drug loading, delivery and antitumor efficiency.

Cited by 46 publications

References 55 publications

Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

Dual Role of Lanthanum Oxide Nanoparticles Functionalized Co‐Polymeric Micelle for Extended Anti‐Cancer Drug Delivery

Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

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