Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

Pijpers, Imke A. B.; Abdelmohsen, Loai K. E. A.; Xia, Yifeng; Cao, Shoupeng; Williams, David; Meng, Fenghua; Hest, Jan C. M. van; Zhong, Zhiyuan

doi:10.1002/adtp.201800068

Cited by 15 publications

(8 citation statements)

References 106 publications

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“…[140][141] Morphology engineering of polymeric self-assemblies has emerged to yield a class of materials that can be used in medical devices and drug delivery systems. [142][143][144] In this context, AIEgenic aggregates based on amphiphilic polymers are very attractive. [41,145] Morphology engineering of AIEgenic assemblies for biomedical applications represents a challenge, due to their complex molecular structure.…”

Section: Morphology Engineering Of Aiegenic Polymeric Assembliesmentioning

confidence: 99%

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

et al. 2021

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Aggregation-induced emission (AIE) is a phenomenon in which fluorescence is enhanced rather than quenched upon molecular assembly. AIE fluorogens (AIEgens) are flexible, conjugated systems that are limited in their dynamics when assembled, which improves their fluorescent properties. This intriguing feature has been incorporated in many different molecular assemblies and has been extended to nanoparticles composed of amphiphilic polymer building blocks. The integration of the fascinating AIE design principle with versatile polymer chemistry opens up new frontiers to approach and solve intrinsic obstacles of conventional fluorescent materials in nanoscience, including the aggregation-caused quenching effect. Furthermore, this integration has drawn significant attention from the nanomedicine community, due to the additional advantages of nanoparticles comprising AIEgenic molecules, such as emission brightness and fluorescence stability. In this regard, a range of AIEgenic amphiphilic polymers have been developed, displaying enhanced emission in the self-assembly/aggregated state. AIEgenic assemblies are regarded as attractive nanomaterials with inherent fluorescence, which display promising features in a biomedical context, for instance in biosensing, cell/tissue imaging and tracking, as well as (photo) therapeutics. In this review, we describe recent strategies for the design and synthesis of novel types of AIEgenic amphiphilic polymers via facile approaches including direct conjugation to natural/synthetic polymers, polymerization, post-polymerization and supramolecular host−guest interactions. Their self-assembly behavior and biomedical potential will be discussed.

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Section: Morphology Engineering Of Aiegenic Polymeric Assembliesmentioning

confidence: 99%

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

et al. 2021

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“…Additionally, the membrane flexibility of PS makes them applicable in targeting and control release. 209 Polymersomes have some similarities to liposomes especially in the structure but are more stable and less permeable than liposomes. The PS is capable to bind with biologically active ligands, antibodies and biotinylated conjugation to their surface which enhances targeted therapy and imaging strategy.…”

Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

144

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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“…[2] Besides that, the chemically versatile nature of the block copolymer constituents allows much freedom concerning tuning the physicochemical properties of the polymersomes, including the incorporation of cell-targeting capacity and stimulus-responsiveness. [3] Fluorescent-labeled polymer-somes are interesting systems for in vivo tracking of nanoparticle transport, monitoring cargo distribution, and cell/ tissue imaging. [4] Tr aditionally,f luorescence is introduced by physically loading conventional fluorescent materials,o rb y chemical conjugation approaches.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo‐Dynamic Therapy

et al. 2021

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Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from ab iomedical point of view,d ue to the advantageous features of loading capacity,emission brightness,and fluorescence stability.Herein, biodegradable polymers comprising poly (ethylene glycol)block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, whichs elfassembled into well-defined polymersomes.T he resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles.T he presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability,w hich improves the efficiency of co-encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo.T his contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.

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Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

Cited by 15 publications

References 106 publications

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo‐Dynamic Therapy

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