Paclitaxel-induced Interstitial Pneumonia after Drug-eluting Stent Implantation: Report of a Fatal Case

Kato, Koichi; Fukuda, Satoshi; Fujimaki, Tetsuo; Takano, Yuko; Kunii, Eiji; Kato, Ken; Watanabe, Kazuko; Suzuki, Shinya; Yamada, Kento; Yokoi, Kiyoshi; Mori, Toshiyuki

doi:10.2169/internalmedicine.48.1901

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…After the literature search and the screening exclusion shown in Fig. 3 , seven articles were included [ 2 – 8 ], comprising 5 in English, 1 in Chinese, and 1 in Japanese, involving eight patients.…”

Section: Case Presentationmentioning

confidence: 99%

Coronary stent implantation links to the occurrence of eosinophilia and interstitial pneumonia: a case report and systematic review

Zhang,

Wang,

Zhu

et al. 2024

BMC Pulm Med

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Background Rapamycin has been extensively utilized for coating coronary artery stents to reduce the occurrence of restenosis, yet there has been limited research on the potential harms of rapamycin-eluting stents. Herein, We report a case of eosinophilia and interstitial pneumonia caused by a cobalt-based alloy stent eluted with rapamycin. Case presentation The patient was admitted due to fever, cough, and expectoration symptoms. Previously, the patient had undergone a procedure of percutaneous coronary stent implantation in our hospital’s cardiology department, which led to a gradual rise in blood eosinophil count. This time, the eosinophil count was higher than the previous admission. A chest CT scan revealed multiple flocculent density increases in both lungs and bronchiectasis. The rapamycin-eluting stents may have caused eosinophilia and interstitial pneumonia, which improved after administering corticosteroids. A systematic review of relevant literature was conducted to summarize the characteristics of interstitial pneumonia caused by drug-eluting stents. Conclusion Paclitaxel, everolimus, zotarolimus, and rapamycin are the types of drugs that can lead to drug-eluting stents, and because of the rarity of their onset, clinical doctors must be precise and prompt in diagnosing suspected cases to avoid misdiagnosis and delayed treatment.

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Section: Case Presentationmentioning

confidence: 99%

Coronary stent implantation links to the occurrence of eosinophilia and interstitial pneumonia: a case report and systematic review

Zhang,

Wang,

Zhu

et al. 2024

BMC Pulm Med

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Everolimus-induced Pneumonitis after Drug-eluting Stent Implantation: A Case Report

Sakamoto

Kikuchi

Ichikawa

et al. 2012

Cardiovasc Intervent Radiol

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Despite the wide use of everolimus as an antineoplastic coating agent for coronary stents to reduce the rate of restenosis, little is known about the health hazards of everolimus-eluting stents (EES). We describe a case of pneumonitis that developed 2 months after EES implantation for angina. Lung pathology demonstrated an organizing pneumonia pattern that responded to corticosteroid therapy. Although the efficacy of EES for ischemic heart disease is well established, EES carries a risk of pneumonitis.

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Lung Injury Caused by Pharmacologic Agents

Henry¹,

Noah²

2019

Kendig's Disorders of the Respiratory Tract in Children

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Paclitaxel-induced Interstitial Pneumonia after Drug-eluting Stent Implantation: Report of a Fatal Case

Abstract: We report a case of paclitaxel-eluting

Cited by 4 publications

References 13 publications

Coronary stent implantation links to the occurrence of eosinophilia and interstitial pneumonia: a case report and systematic review

Coronary stent implantation links to the occurrence of eosinophilia and interstitial pneumonia: a case report and systematic review

Everolimus-induced Pneumonitis after Drug-eluting Stent Implantation: A Case Report

Lung Injury Caused by Pharmacologic Agents

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