Paclitaxel-Eluting Polymer Film Reduces Locoregional Recurrence and Improves Survival in a Recurrent Sarcoma Model: A Novel Investigational Therapy

Liu, Rong; Wolinsky, Jesse B.; Catalano, Paul J.; Chirieac, Lucian R.; Wagner, Andrew J.; Grinstaff, Mark W.; Colson, Yolonda L.; Raut, Chandrajit P.

doi:10.1245/s10434-011-1871-4

Cited by 45 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last decade, emerging thermosensitive hydrogels have been reported as sustainable DDSs; however, hydrogels have a relatively fast degradation speed. Polymeric films have effectively prevented cancer relapse in the resection site of primary cancers (Liu et al, 2010(Liu et al, , 2012. In agreement with the polymer films, the PDLLA nanofibers used in our study exhibited outstanding biocompatibility and biodegradability, as well as a consistent drug-release rate.…”

Section: Discussionsupporting

confidence: 79%

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Ding

Yang

et al. 2015

Drug Delivery

View full text Add to dashboard Cite

The aim of this study was to develop docetaxel (DTX)-loaded poly-d,l-lactide (PDLLA) nanofibers and evaluate their therapeutic effect in preventing local breast cancer recurrence. DTX was incorporated into biodegradable PDLLA nanofibers by electrospinning. The surface morphology of the DTX/PDLLA nanofibers was characterized using scanning electron microscopy and wide angle X-ray diffraction. The in vitro release behavior of DTX from the fiber mats was also studied in detail. The cytotoxicity of DTX/PDLLA nanofibers was evaluated by MTT assay in 4T1 breast cancer cells. Flow cytometry revealed that DTX/PDLLA nanofibers exhibited apoptotic activity in 4T1 cells. In vivo antitumor efficacy of DTX/PDLLA nanofibers was evaluated in BALB/c mice bearing local breast tumors. Locoregional recurrence after primary tumor resection decreased obviously in mice treated with subcutaneously (16.7%) administered DTX-loaded PDLLA nanofibers, compared with the blank PDLLA nanofibers (88.9%), systemic (75.0%) or locally (77.8%) administered DTX and the control group (100%) (p < 0.05). Finally, after subcutaneous transplantation in mice, the DTX/PDLLA scaffolds presented excellent biocompatibility, as exhibited by the minimal presence of inflammatory cells in the region surrounding the scaffolds. Our results suggest that DTX/PDLLA nanofibers could have great potential for clinical application requiring local chemotherapy.

show abstract

Section: Discussionsupporting

confidence: 79%

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Ding

Yang

et al. 2015

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…21,22 Therefore, since 1970s fundamental explorations on effective drug delivery systems have aimed to optimize the anti-tumor activity of parent drugs/radioactive particles, diminish non-selective toxicity and improve quality of life for cancer patients. 8,23,24 Several novel DDSs including expansile nanoparticles, 25 polymeric platforms 11,26 and chitosan hydrogel, 27,28 have been applied to retard or postpone tumor relapse in animal models. Despite plenty of advantages in local therapy, some of the referring DDSs have confronted certain barriers to maintain sustained local drug concentration in satisfactory ways.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic application of injectable thermosensitive hydrogel in preventing local breast cancer recurrence and improving incision wound healing in a mouse model

et al. 2012

View full text Add to dashboard Cite

Many drug delivery systems (DDSs) have been investigated for local targeting of malignant disease with the intention of increasing anti-tumor activity and minimizing systemic toxicity. An injectable thermosensitive hydrogel was applied to prevent locoregional recurrence of 4T1 breast cancer in a mouse model. The presented hydrogel, which is based on poly(ethyleneglycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE), flows freely at normal temperature, forms a gel within seconds in situ at body temperature, and eventually releases the drug in a consistent and sustained fashion as it gradually biodegrades. Locoregional recurrence after primary tumor removal was significantly inhibited in mice treated with the paclitaxel (PTX)-loaded PECE hydrogel subcutaneously (9.1%) administered, compared with the blank hydrogel (80.0%), systemic (77.8%) and locally (75.0%) administered PTX, and the control group (100%) (P < 0.01). In addition, tensile strength measurements of the surgical incisions showed that the PECE hydrogel accelerates wound healing at postoperative day 7 (P < 0.05), and days 4 and 14 (P > 0.05), in agreement with histopathological examinations. This novel DDSs represents a promising approach for local adjuvant therapy in malignant disease.

show abstract

“…They are mainly biodegradable polymer based platforms in order to avoid repeated removal surgery. 22–24 Alt hough the nanoscale two-dimensional (2D) mesh reported recently can be effectively internalized by the cells after localized injection, it may also possibly to migrate away from the tumor site due to its low dimension in an in vivo environment. 25 Recently, a series of implantable electrospun nanofibrous LDDSs have shown superior therapeutic performance in cancer treatment due to their unique strength in ensuring therapeutic dosage levels at the tumor site for extended period while maintaining low systematic drug exposure.…”

Section: Introductionmentioning

confidence: 99%

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

Ren

et al. 2017

J. Mater. Chem. B

View full text Add to dashboard Cite

Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy. The exploration of nanoparticle based drug delivery systems (DDSs) faces daunting challenges in low efficacy of intracellular delivery. Herein, a localized drug delivery device consisting of photoluminescent mesoporous silica nanoparticles (PLMSNs) and photothermal fibrous matrix was investigated. Specifically, PLMSNs modified with a pH-sensitive polydopamine (PDA) ‘gatekeeper’ served as a doxorubicin (DOX) carrier and could release DOX once the PLMSNs were up-taken by the cancer cells. The PLMSNs were electrostatically assembled on the surface of electrospun biodegradable poly(ε-caprolactone)/gelatin fibrous mesh incorporated with photothermal carbon nanoparticles (CNPs), leading to an implantable patch used as localized delivery platform. Comparing to free particulate DDSs, this implantable composite patch device was found to significantly enable superior cell up-taking effect and consequently enhance in-vitro therapeutic efficacy against tumor cells. Namely, under near infrared irradiation, the photothermal effect of CNPs in the implantable patch weakens the electrostatic interaction between the PLMSNs and poly(ε-caprolactone)/gelatin/CNP fibrous mesh, resulting in the controlled release of the PLMSNs and subsequent internalization into the tumor cells for more effective cancer cell killing. This implantable therapeutic device may therefore inspire another way of developing localized cancer therapy.

show abstract

Paclitaxel-Eluting Polymer Film Reduces Locoregional Recurrence and Improves Survival in a Recurrent Sarcoma Model: A Novel Investigational Therapy

Cited by 45 publications

References 38 publications

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence

Therapeutic application of injectable thermosensitive hydrogel in preventing local breast cancer recurrence and improving incision wound healing in a mouse model

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

Contact Info

Product

Resources

About