Pacinian hypertrophy in a type 2A hand burn contracture and Pacinian hypertrophy and hyperplasia in a Dupuytren's contracture

Yenidünya, Mehmet Oğuz; Yenıdünya, Sibel; Seven, Ergin

doi:10.1016/j.burns.2008.01.019

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…In contrast to previous studies (Ehrmantant et al, 2004; Yenidunya et al, 2009), we observed that approximately 65% of the PF Pacinian corpuscles showed signs of partial or total denervation (Zelená, 1994). Our findings are in line with those of Mikusev (1989), who described the 'deformation' of Pacinian corpuscles and degeneration of nerve fibres in the first stages of PF, followed by the loss of Pacinian corpuscles in later stages.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to other studies (Akyürek et al, 2000; von Campe et al, 2012), we did not find evidence of Pacinian corpuscle hyperplasia in the palmar aponeuroses of patients with PF. Instead, we observed enlarged Pacinian corpuscles, which is consistent with the reports from Ehrmantant et al (2004) and Yenidunya et al (2009). Ehrmantant et al (2004) observed that the Pacinian corpuscles of PF patients had significantly more layers.…”

Section: Discussionsupporting

confidence: 93%

“…In the context of PF, changes in the structure (Ehrmantant et al, 2004), number and size (Akyürek et al, 2000; Yenidunya et al, 2009) of Pacinian corpuscles have been reported. Stecco et al (2018) recently observed that the density of free nerve endings in the palmar aponeuroses of patients with palmar fibromatosis is increased, but they did not provide information about changes to the other types of sensory corpuscles.…”

Section: Introductionmentioning

confidence: 99%

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Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

et al. 2021

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The human palmar aponeurosis is involved in hand proprioception, and it contains different sensory corpuscle morphotypes that serve this role. In palmar fibromatosis (classically referred to as Dupuytren's disease), the palmar aponeurosis undergoes fibrous structural changes that, presumably, also affect the nervous system, causing altered perception. We analysed the various sensory nerve formation morphotypes in the palmar aponeuroses of healthy subjects and patients with palmar fibromatosis. To do this, we used immunohistochemistry for corpuscular constituents and the putative mechanoproteins PIEZO2 and acid‐sensing ion channel 2. Free nerve endings and Golgi‐Mazzoni, Ruffini, paciniform and Pacinian corpuscles were identified in both the healthy and the pathological conditions. The densities of the free nerve endings and Golgi‐Mazzoni corpuscles were slightly increased in the pathological tissues. Furthermore, the Pacinian corpuscles were enlarged and displayed an altered shape. Finally, there was also morphological and immunohistochemical evidence of occasional denervation of the Pacinian corpuscles, although no increase in their number was observed. Both PIEZO2 and acid‐sensing ion channel 2 were absent from the altered corpuscles. These results indicate that the human palmar aponeurosis is richly innervated, and the free nerve endings and sensory corpuscles within the palmar aponeurosis undergo quantitative and qualitative changes in patients with palmar fibromatosis, which may explain the sensory alterations occasionally reported for this pathology.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

et al. 2021

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“…8,9,20 One of our cases had enlarged Pacinian corpuscles and an increased density of these corpuscles. The increase in density and enlargement of Pacinian corpuscles might be linked to local release of growth factors, 14 as the capsules of the Pacinian corpuscles were strongly positive for nerve growth factor receptor.…”

Section: Discussionmentioning

confidence: 56%

Painful Nodules and Cords in Dupuytren Disease

Campe

Mende

Omaren

et al. 2012

The Journal of Hand Surgery

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“…The coexistence of PCNH with other lesions, such as glomus tumour, Dupuytren’s contracture, foreign body reaction, neurofibromatosis type 1, type 2A burns, and congenital macrodactyly has been described (31%) (Akyürek et al., 2000; Greider and Flatt, 1982; Komforti and Cummings, 2015; Mahipathy et al., 2015; Rinaldi et al., 2000; von Campe et al., 2012; Yan et al., 2006; Yenidunya et al., 2009).…”

Section: Resultsmentioning

confidence: 99%

Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

Fassola

Wenzke

Ertel

et al. 2019

J Hand Surg Eur Vol

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Tumours involving Pacinian corpuscles are rare. The literature identifies two main pathological disorders: the Pacinian corpuscle neuroma or hyperplasia and the Pacinian corpuscle neurofibroma. Published data are confusing and at times conflicting. This systematic review summarizes the available data in order to support clinicians in the differential diagnosis with other tumours responsible for unclear symptoms in the hands and fingers. We identified 67 pertinent articles. Although some similarities have been described, the two tumours have relevant differences, specifically when comparing age of the patient, location, symptoms, characteristic of a mass, and aetiology. All these factors should be taken into account in order to improve diagnostic accuracy. Despite the low incidence of unsuccessful surgeries, extraordinary measures are occasionally necessary to achieve complete resolution of symptoms.

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Pacinian hypertrophy in a type 2A hand burn contracture and Pacinian hypertrophy and hyperplasia in a Dupuytren's contracture

Cited by 13 publications

References 26 publications

Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

Painful Nodules and Cords in Dupuytren Disease

Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

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