Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

Fassola, Isabella; Wenzke, Lena; Ertel, Wolfgang; Krasnici, Senat

doi:10.1177/1753193419852118

Cited by 12 publications

(9 citation statements)

References 55 publications

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“… 5 Trauma has been hypothesized to disrupt the blood flow of arteriovenous anastomoses located close to Pacinian corpuscles, resulting in the formation of new corpuscles. 1 Pain is the most common symptom and has been reported in 84.6% of patients. 4 , 6 Pacinian corpuscle hyperplasia is often related to the common digital nerve of the index, middle, and ring fingers, and only a few cases have been reported in the distal phalanx.…”

Section: Discussionmentioning

confidence: 99%

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Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report

et al. 2021

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Summary Pacinian corpuscle hyperplasia is a pathological increase in the size (Pacinian hypertrophy) and/or density of mature Pacinian corpuscles. Although its aetiology and pathogenesis remain unclear, surgery is the main treatment. Here, we report a rare case of Pacinian hypertrophy at the fingertip treated with surgical excision and reconstruction using a reverse digital artery flap. A 47-year-old man presented with injuries to his right little finger, which was wedged in a door while unloading a truck. His fingertip was amputated and stump plasty was performed. However, severe pain persisted at the fingertip for 5 months after the surgery. Therefore, the painful part of his fingertip was resected, and reconstruction was performed using a reverse digital artery flap 6 months after the injury. Haematoxylin and eosin staining of the resected specimen revealed scar tissue with foreign body reaction and mild Pacinian hypertrophy. One year has passed since the injury, and the pain has completely disappeared. The patient regained complete range of motion in his little finger and was able to resume work without any limitations. Surgical excision with sufficient margin and reconstruction with a reverse digital artery flap is a reliable method to relieve pain due to Pacinian hypertrophy at the fingertip.

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Section: Discussionmentioning

confidence: 99%

“…The term Pacinian corpuscle hyperplasia is used interchangeably with Pacinian neuroma. 1 Here, we report a rare case of Pacinian hypertrophy at the fingertip treated with surgical excision and reconstruction using a reverse digital artery flap. 2 …”

Section: Introductionmentioning

confidence: 96%

Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report

et al. 2021

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“…Pacinian corpuscles in adult subjects survive denervation, showing no structural nor immunohistochemical changes [ 39 ]. Tumors involving Pacinian corpuscles are rare and have been defined as Pacinian corpuscle neuroma (or hyperplasia) and neurofibroma [ 40 ], which are occasionally painful [ 41 ]. Hyperplasia and hypertrophy of Pacinian corpuscles adjacent to digital nerves have been reported, although they are very rare [ 42 , 43 , 44 , 45 ].…”

Section: Clinical and Pathological Interest Of Cutaneous Sensory Cmentioning

confidence: 99%

The Human Cutaneous Sensory Corpuscles: An Update

Cobo

García‐Piqueras

Cobo

et al. 2021

JCM

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Sensory corpuscles of human skin are terminals of primary mechanoreceptive neurons associated with non-neuronal cells that function as low-threshold mechanoreceptors. Structurally, they consist of an extreme tip of a mechanosensory axon and nonmyelinating peripheral glial cells variably arranged according to the morphotype of the sensory corpuscle, all covered for connective cells of endoneurial and/or perineurial origin. Although the pathologies of sensitive corpuscles are scarce and almost never severe, adequate knowledge of the structure and immunohistochemical profile of these formations is essential for dermatologists and pathologists. In fact, since sensory corpuscles and nerves share a basic structure and protein composition, a cutaneous biopsy may be a complementary method for the analysis of nerve involvement in peripheral neuropathies, systemic diseases, and several pathologies of the central nervous system. Thus, a biopsy of cutaneous sensory corpuscles can provide information for the diagnosis, evolution, and effectiveness of treatments of some pathologies in which they are involved. Here, we updated and summarized the current knowledge about the immunohistochemistry of human sensory corpuscles with the aim to provide information to dermatologists and skin pathologists.

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“…Over the years, there has been considerable variation in its description. It has been described by various other terms, such as plexiform neurofibroma with aberrant tactile corpuscles, benign fibromyxoma, Pacinian neurofibromatosis, neurofibroma plexiform, myxoid neurofibroma, bizarre cutaneous neurofibroma, and nerve sheath myxoma; some of these are used synonymously while the others are misnomers or represent other tumors [ 39 ].…”

Section: Histopathological Variantsmentioning

confidence: 99%

“…It can be sporadic or associated with NF1. Histopathologically, it is a well-demarcated dermal tumor, often extending to subcutaneous fat composed of variably sized round or ovoid lobules, each showing a central homogeneous, hypocellular, eosinophilic core surrounded by as many as 30 pale-staining, concentric collagenous lamellae resembling Pacinian corpuscles ( Figure 5 ) [ 39 ]. The superficial corpuscles tend to be smaller (4–7 lamellae), and deeper immature corpuscles are larger.…”

Section: Histopathological Variantsmentioning

confidence: 99%

Histopathological Variants of Cutaneous Neurofibroma: A Compendious Review

Nagrani

Bhawan

2022

Dermatopathology

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The first description of histopathological variants of neurofibroma dates back to 1994. Over the years, many individual case reports elucidating unusual histologic features in neurofibroma have been added to the literature, some of which have defined criteria, with the others falling under the roof of benign neural neoplasms. These unusual features, which sometimes may lead to pauses in identifying a common benign tumor such as neurofibroma. Awareness of these variants may help dermatopathologists avoid misinterpretation. Thus, this review aims to summarize all novel and unusual histopathological variants of cutaneous neurofibroma reported to date, in addition to any unusual variants that we encountered in our practice.

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Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review

Cited by 12 publications

References 55 publications

Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report

Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report

The Human Cutaneous Sensory Corpuscles: An Update

Histopathological Variants of Cutaneous Neurofibroma: A Compendious Review

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