Pacemaker Currents in Dopaminergic Neurones of the Mice Olfactory Bulb

Pignatelli, Angela; Gambardella, Cristina; Borin, Mirta; Iseppe, Alex Fogli; Belluzzi, Ottorino

doi:10.5772/21959

Cited by 4 publications

(8 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complex pattern of voltage-dependent conductance of PG-DA cells that determines their excitability profile, including the pacemaker machinery, has been completely described in our laboratory (Pignatelli et al, 2005(Pignatelli et al, , 2012Pignatelli and Belluzzi, 2017). The first electrophysiological feature of bulbar DA cells is that they have spontaneous activity, mainly within the theta frequency range (4-12 Hz).…”

Section: Electrophysiological Characteristics Of the Da Cells Of The Olfactory Bulbmentioning

confidence: 99%

See 1 more Smart Citation

Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb

Capsoni

Iseppe

Casciano

et al. 2021

Front. Neural Circuits

Self Cite

View full text Add to dashboard Cite

The perception and discriminating of odors are sensory activities that are an integral part of our daily life. The first brain region where odors are processed is the olfactory bulb (OB). Among the different cell populations that make up this brain area, interneurons play an essential role in this sensory activity. Moreover, probably because of their activity, they represent an exception compared to other parts of the brain, since OB interneurons are continuously generated in the postnatal and adult period. In this review, we will focus on periglomerular (PG) cells which are a class of interneurons found in the glomerular layer of the OB. These interneurons can be classified into distinct subtypes based on their neurochemical nature, based on the neurotransmitter and calcium-binding proteins expressed by these cells. Dopaminergic (DA) periglomerular cells and calretinin (CR) cells are among the newly generated interneurons and play an important role in the physiology of OB. In the OB, DA cells are involved in the processing of odors and the adaptation of the bulbar network to external conditions. The main role of DA cells in OB appears to be the inhibition of glutamate release from olfactory sensory fibers. Calretinin cells are probably the best morphologically characterized interneurons among PG cells in OB, but little is known about their function except for their inhibitory effect on noisy random excitatory signals arriving at the main neurons. In this review, we will mainly describe the electrophysiological properties related to the excitability profiles of DA and CR cells, with a particular view on the differences that characterize DA mature interneurons from cells in different stages of adult neurogenesis.

show abstract

Section: Electrophysiological Characteristics Of the Da Cells Of The Olfactory Bulbmentioning

confidence: 99%

“…Two of the small voltage-dependent conductance were identified in a persistent Na + current (INa P ) and a T-type Ca 2+ current (ICa T ) and are responsible for the spontaneous activity of these interneurons (Pignatelli et al, 2012).…”

Section: Electrophysiological Characteristics Of the Da Cells Of The Olfactory Bulbmentioning

confidence: 99%

Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb

Capsoni

Iseppe

Casciano

et al. 2021

Front. Neural Circuits

Self Cite

View full text Add to dashboard Cite

show abstract

“…As most DA neurones, bulbar DA cells have a spontaneous activity, primarily within the theta frequency range (4–12 Hz); the pacemaking machinery is composed of a system of two small inward currents, a persistent sodium current (I Na(P) ; 0.41 nS) and a T-type Ca 2+ current (I Ca(T) ; 0.35 nS; Pignatelli et al, 2012 ).…”

Section: Electrophysiology Of Mature Bulbar Da Neuronesmentioning

confidence: 99%

“…The mechanisms governing autorhythmicity of TH-GFP cells in external plexiform and glomerular layers are essentially the same: as for mature DA neurones, TH-GFP neurones in the EPL display a persistent Na-current (I NaP ) and a T-type calcium current, and the pharmacological block of any of them also reversibly blocks the spontaneous activity (Pignatelli et al, 2012 ).…”

Section: Electrophysiology Of Da Neurones During Adult Neurogenesismentioning

confidence: 99%

Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective

Pignatelli

Belluzzi

2017

Front. Neuroanat.

Self Cite

View full text Add to dashboard Cite

The olfactory bulb (OB), the first center processing olfactory information, is characterized by a vigorous life-long activity-dependent plasticity responsible for a variety of odor-evoked behavioral responses. It hosts the more numerous group of dopaminergic (DA) neurones in the central nervous system, cells strategically positioned at the entry of the bulbar circuitry, directly in contact with the olfactory nerve terminals, which play a key role in odor processing and in the adaptation of the bulbar network to external conditions. Here, we focus mainly on the electrophysiological properties of DA interneurones, reviewing findings concerning their excitability profiles in adulthood and in different phases of adult neurogenesis. We also discuss dynamic changes of the DA interneurones related to environmental stimuli and their possible functional implications.

show abstract

“…On the other hand, all three DaN populations are characterized as autonomous pacemakers [40,55,56]. The pacemaking machinery of VTA and OB DaNs is mainly driven by a persistent sodium current [40,57,58]. Conversely, SNc pacemaker activity is associated with Ca 2+ influx through plasma membrane Ca v 1.3 channels, postulated to cause oxidant stress in the mitochondrial compartment [59,60].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection

et al. 2020

View full text Add to dashboard Cite

Understanding non-motor symptoms of Parkinson's disease is important in order to unravel the underlying molecular mechanisms of the disease. Olfactory dysfunction is an early stage, non-motor symptom which occurs in 95% of Parkinson's disease patients. Mitochondrial dysfunction is a key feature in Parkinson's disease and importantly contributes to the selective loss of dopaminergic neurons the substantia nigra pars compacta. The olfactory bulb, the first olfactory processing station, also contains dopaminergic neurons, which modulate odor information and thereby enable odor detection as well as odor discrimination. MitoPark mice are a genetic model for Parkinson's disease with severe mitochondrial dysfunction, reproducing the differential vulnerability of dopaminergic neurons in the midbrain. These animals were used to investigate the impact of mitochondrial dysfunction on olfactory-related behavior and olfactory bulb dopaminergic neuron survival. Odor detection was severely impaired in MitoPark mice. Interestingly, only the small anaxonic dopaminergic subpopulation, which is continuously replenished by neurogenesis, was moderately reduced in number, much less compared with dopaminergic neurons in the midbrain. As a potential compensatory response, an enhanced mobilization of progenitor cells was found in the subventricular zone. These results reveal a high robustness of dopaminergic neurons located in the olfactory bulb towards mitochondrial impairment, in striking contrast to their midbrain counterparts.

show abstract

Pacemaker Currents in Dopaminergic Neurones of the Mice Olfactory Bulb

Cited by 4 publications

References 63 publications

Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb

Unraveling the Role of Dopaminergic and Calretinin Interneurons in the Olfactory Bulb

Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective

The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection

Contact Info

Product

Resources

About