Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective

Pignatelli, Angela; Belluzzi, Ottorino

doi:10.3389/fnana.2017.00007

Cited by 51 publications

(45 citation statements)

References 139 publications

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“…we observed a wide distribution of neuronal areas for these DA neurons (Figure 2H), which coincides with previous findings that OB DA neuron subtypes may be distinguished by their size (Pignatelli et al, 2005;Kosaka and Kosaka, 2009;Chand et al, 2015;Pignatelli and Belluzzi, 2017;Galliano et al, 2018;Kosaka et al, 2019). Given the previous findings (Halász et al, 1981;Pignatelli et al, 2005;Kosaka and Kosaka, 2007) of differences in soma sizes between two potential populations of OB DA neurons and our finding that neuronal areas of DA neurons are widely distributed (Figure 2H), we also compared these same properties between recorded DA neurons with different sizes ( Table 2).…”

Section: Membrane Propertiessupporting

confidence: 90%

Spiking and Membrane Properties of Rat Olfactory Bulb Dopamine Neurons

Korshunov

Blakemore

Bertram

et al. 2020

Front. Cell. Neurosci.

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The mammalian olfactory bulb (OB) has a vast population of dopamine (DA) neurons, whose function is to increase odor discrimination through mostly inhibitory synaptic mechanisms. However, it is not well understood whether there is more than one neuronal type of OB DA neuron, how these neurons respond to different stimuli, and the ionic mechanisms behind those responses. In this study, we used a transgenic rat line (hTH-GFP) to identify fluorescent OB DA neurons for recording via wholecell electrophysiology. These neurons were grouped based on their localization in the glomerular layer ("Top" vs. "Bottom") with these largest and smallest neurons grouped by neuronal area ("Large" vs. "Small," in µm 2 ). We found that some membrane properties could be distinguished based on a neuron's area, but not by its glomerular localization. All OB DA neurons produced a single action potential when receiving a sufficiently depolarizing stimulus, while some could also spike multiple times when receiving weaker stimuli, an activity that was more likely in Large than Small neurons. This single spiking activity is likely driven by the Na + current, which showed a sensitivity to inactivation by depolarization and a relatively long time constant for the removal of inactivation. These recordings showed that Small neurons were more sensitive to inactivation of Na + current at membrane potentials of −70 and −60 mV than Large neurons. The hyperpolarizationactivated H-current (identified by voltage sags) was more pronounced in Small than Large DA neurons across hyperpolarized membrane potentials. Lastly, to mimic a more physiological stimulus, these neurons received ramp stimuli of various durations and current amplitudes. When stimulated with weaker/shallow ramps, the neurons needed less current to begin and end firing and they produced more action potentials at a slower frequency. These spiking properties were further analyzed between the four groups of neurons, and these analyses support the difference in spiking induced with current step stimuli. Thus, there may be more than one type of OB DA neuron, and these neurons' activities may support a possible role of being high-pass filters in the OB by allowing the transmission of stronger odor signals while inhibiting weaker ones.

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Section: Membrane Propertiessupporting

confidence: 90%

Spiking and Membrane Properties of Rat Olfactory Bulb Dopamine Neurons

Korshunov

Blakemore

Bertram

et al. 2020

Front. Cell. Neurosci.

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“…An alternative explanation is that the olfactory neurons themselves are affected during Parkinson’s disease progression. Olfactory neurons are part of the dopaminergic system (Pignatelli & Belluzzi, 2017) and the olfactory receptors are housed in cilia on these cells. If early in the development of Parkinson’s disease the ability of olfactory neurons to renew cilia was compromised then so would the sense of smell.…”

Section: Discussionmentioning

confidence: 99%

Alpha synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome

Iqbal

Baldrighi

Murdoch

et al. 2019

Preprint

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“…Comparatively, the presence of DA cells in the olfactory bulbs is a common feature shared by all vertebrates (Smeets & González, ; Yamamoto & Vernier, ) and they make abundant locally restricted connections. Actually, the mammalian olfactory bulb hosts the most numerous group of DA neurons (Cave & Baker, ) which play a key role in odor processing and in the adaptation of the bulbar network to external conditions (Pignatelli & Belluzzi, ).…”

Section: Discussionmentioning

confidence: 99%

Organization of the catecholaminergic systems in the brain of lungfishes, the closest living relatives of terrestrial vertebrates

López

González

2017

J of Comparative Neurology

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Lungfishes are a group of sarcopterygian fishes currently considered the closest living relatives of tetrapods, and represent an interesting group for the study of evolutionary traits in the transition from fishes to tetrapods. Catecholaminergic systems in the brain are among the most carefully analyzed neurotransmitter systems in the brain of most vertebrate groups. Their organization shows major shared characteristics, although traits particular to each vertebrate class have also been found, primarily between anamniotes and amniotes. Given the relevance of lungfishes in evolutionary terms, the present study provides the first comprehensive and detailed map of the catecholaminergic structures in the brain of two representative species of lungfishes, an African lungfish (Protopterus dolloi) and the Australian lungfish (Neoceratodus forsteri), as revealed by immunohistochemistry. Distinct groups of catecholaminergic cells were observed in the olfactory bulb, pallium, and preoptic area of the telencephalon, and the subpallium is devoid of these cells. Hypothalamic and diencephalic groups were detected and, in particular, the dopaminergic nucleus of the periventricular organ was evidenced with dopamine antibodies but not with anti-tyrosine hydroxylase. A well developed mesostriatal system was revealed formed by conspicuous groups of dopamine cells in the midbrain tegmentum and profuse innervation of the subpallium. Comparison of these results with those from other classes of vertebrates shows numerous common traits shared by most groups and also highlights particular features in lungfishes different from actinopterygian fishes that resemble those of amphibians and amniotes.

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Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective

Cited by 51 publications

References 139 publications

Spiking and Membrane Properties of Rat Olfactory Bulb Dopamine Neurons

Spiking and Membrane Properties of Rat Olfactory Bulb Dopamine Neurons

Alpha synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome

Organization of the catecholaminergic systems in the brain of lungfishes, the closest living relatives of terrestrial vertebrates

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