Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma

Abstract

BackgroundWe have developed magnetite cationic liposomes (MCLs) and applied them to local hyperthermia as a mediator. MCLs have a positive charge and generate heat under an alternating magnetic field (AMF) by hysteresis loss. In this study, the effect of hyperthermia using MCLs was examined in an in vivo study of hamster osteosarcoma.MethodMCLs were injected into the osteosarcoma and then subjected to an AMF.ResultsThe tumor was heated at over 42°C, but other normal tissues were not heated as much. Complete regression was observed in 100% of the treated group hamsters, whereas no regression was observed in the control group hamsters. At day 12, the average tumor volume of the treated hamsters was about 1/1000 of that of the control hamsters. In the treated hamsters, no regrowth of osteosarcomas was observed over a period of 3 months after the complete regression.ConclusionThese results suggest that this treatment is effective for osteosarcoma.

Biocompatibility of various ferrite nanoparticles evaluated by in vitro cytotoxicity assays using HeLa cells

“…The temperature rise in an ac magnetic field and the ensuing cytotoxicity of Fe 3 O 4 , dextran-coated magnetite [6,7], magnetite cationic liposome [8], and others [9,10] has been reported. The nanoparticles are coated with some materials in order to improve their biocompatibility, to provide the specific functionalization to cancer cells and to avoid the aggregation among the particles by magnetic force.…”

Studies of zinc phthalocyanine/magnetic fluid complex as a bifunctional agent for cancer treatment

“…On the other hand, nanostructured magnetic materials, as for instance biocompatible magnetic fluids, have been pointed out as very promising material basis for tumor therapy. This is essentially based on local hyperthermia (HPT) of biological tissues induced by external AC magnetic fields [5][6][7][8][9]. The present study introduces a new material class that allows the combined action of PDT and HPT therapies, designed to work in a synergetic way, leading to an expected enhancement of the tumor damage after minimum drug doses and based on heat dissipation and/or light photosensitization [10].…”

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

“…Magnetic cationic liposomes (MCL) with superparamagnetic iron oxide nanoparticles were developed by Mastsuka et al [725] to investigate the in vivo efficacy in hyperthermia application. Resultant MCLs were directly injected into a hamster osteosarcoma.…”