Biocompatibility of various ferrite nanoparticles evaluated by in vitro cytotoxicity assays using HeLa cells

Tomitaka, Asahi; Hirukawa, A.; Yamada, Tsutomu; Morishita, Shin; Takemura, Yasushi

doi:10.1016/j.jmmm.2009.02.058

Cited by 119 publications

(62 citation statements)

References 16 publications

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“…Similarly, it has been reported that nanoparticles prepared from different bulk materials explicate their actions which mainly depends on the chemical composition as well as their sizes and shapes [56]. Our study is in agreement with the earlier reports where CaFe 2 O 4 nanoparticles were shown to exhibit high toxicity when used above 250 µg/mL concentration [40], while MnFe 2 O 4 , ZnFe 2 O 4 , NiFe 2 O 4 nanoparticles at 100 µg/mL concentration have shown less cell viability [57,58]. Gupta et al (2005) [59] stated that the magnetic nanoparticles size ranging from 10 to 100 nm is considered to be ideal for their application in the biomedical field.…”

Section: Cytotoxicity Analysissupporting

confidence: 92%

“…Sci. 2016, 6, 184 9 of 13 shown to exhibit high toxicity when used above 250 μg/mL concentration [40], while MnFe2O4, ZnFe2O4, NiFe2O4 nanoparticles at 100 μg/mL concentration have shown less cell viability [57,58]. Gupta et al (2005) [59] stated that the magnetic nanoparticles size ranging from 10 to 100 nm is considered to be ideal for their application in the biomedical field.…”

Section: Cytotoxicity Analysismentioning

confidence: 99%

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Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

et al. 2016

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Spinel copper ferrite (CuFe 2 O 4 ) and zinc ferrite (ZnFe 2 O 4 ) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). XRD patterns conform to the copper ferrite and zinc ferrite formation, and the average particle sizes were calculated by using a transmission electron microscope, the measured particle sizes being 56 nm for CuFe 2 O 4 and 68 nm for ZnFe 2 O 4. Both spinel ferrite nanoparticles exhibit ferromagnetic behavior with saturation magnetization of 31 emug´1 for copper ferrite (50.63 Am 2 /Kg) and 28.8 Am 2 /Kg for zinc ferrite. Both synthesized ferrite nanoparticles were equally effective in scavenging 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radicals. ZnFe 2 O 4 and CuFe 2 O 4 nanoparticles showed 30.57%˘1.0% and 28.69%˘1.14% scavenging activity at 125 µg/mL concentrations. In vitro cytotoxicity study revealed higher concentrations (>125 µg/mL) of ZnFe 2 O 4 and CuFe 2 O 4 with increased toxicity against MCF-7 cells, but were found to be non-toxic at lower concentrations suggesting their biocompatibility.

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Section: Cytotoxicity Analysissupporting

confidence: 92%

Section: Cytotoxicity Analysismentioning

confidence: 99%

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

et al. 2016

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“…Low cost, environmentally benign as well as biocompatible iron-based oxides 29 have received increasing interest of scientific investigation. However, the reduced iron during the lithiation process is itself not electrochemically active to Li + .…”

Section: Introductionmentioning

confidence: 99%

Nanostructured ZnFe2O4 as Anode Material for Lithium-Ion Batteries: Ionic Liquid-Assisted Synthesis and Performance Evaluation with Special Emphasis on Comparative Metal Dissolution

Jia

Kloepsch

et al. 2016

ACSi

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In memoriam of Janez (Janko) Jamnik, a brilliant scientist with an exceptional combination of great leadership capabilities and a friendly and kind personality AbstractIn this work, a ZnFe 2 O 4 anode material was successfully synthesized by a novel ionic liquid-assisted synthesis method followed by a carbon coating procedure. The as-prepared ZnFe 2 O 4 particles demonstrate a relatively homogeneous particle size distribution with particle diameters ranging from 40 to 80 nm. This material, which is well known to offer an interesting combination of an alloying and conversion mechanism, is capable of accommodating nine equivalents of lithium per unit formula, resulting in a high specific capacity (≥ 1,000 mAh g -1 ). The resulting composite anode material displayed a stable capacity of ca. 1,091 mAh g -1 for 190 cycles at a medium de-lithiation potential of 1.7 V and at a charge/discharge rate of 1C. Furthermore, the material displays an excellent high rate capability up to 20C, displaying a reversible capacity of still 216 mAh g -1 . Studies on Fe and Zn losses of the ZnFe 2 O 4 active material by dissolution in the electrolyte were performed and compared to those of silicon-, germanium-and tin-based high-capacity anode materials. In conclusion, ion dissolution from metal containing anode materials should not be underestimated in view of its impact on the overall cell performance and cycling stability.

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“…Higher temperatures up to 56°C, which yield widespread necrosis, coagulation, or carbonization (depending on temperature), are called 'thermoablation'. Hyperthermia is advantageous in that it has fewer side effects than thermoablation, chemotherapy, or radiation, and it has been investigated for many years in the treatment of a wide variety of malignant tumors in both experimental animals and patients (Tomitaka et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Controlling the optimum dose of AMPTS functionalized-magnetite nanoparticles for hyperthermia cancer therapy

Arum

Song

2011

Appl Nanosci

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Biocompatibility of various ferrite nanoparticles evaluated by in vitro cytotoxicity assays using HeLa cells

Cited by 119 publications

References 16 publications

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

Nanostructured ZnFe2O4 as Anode Material for Lithium-Ion Batteries: Ionic Liquid-Assisted Synthesis and Performance Evaluation with Special Emphasis on Comparative Metal Dissolution

Controlling the optimum dose of AMPTS functionalized-magnetite nanoparticles for hyperthermia cancer therapy

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