P859 GenotypinggyrA andpenA from remnantneisseria gonorrhoeaepositive cepheid xpert® clinical specimens

Abstract

discriminating influence were Lactobacillus, Anaerococcus, and Staphylococcus. In crude analysis, cytokines TNF-a/IP-10/IL-10 were elevated among MSWomen (p<0.05, each); IL-8 did not differ by group; IL-1b was higher among MSM (p=0.03). Cytokine concentration increased in response to Corynebacterium (IL-8/TNF-a/IP-10/IL-1b), Gardnerella (IL-8/IP-10/IL-1b), Veillonella (IL-8/IP-10/IL-1b), and Peptoniphilus (IL-8/IL-1b). Microbiome composition did not account for the difference in TNF-a, IP-10, or IL-10 between groups; the difference in IL-1b became non-significant after accounting for taxa. Among MSWomen, IL-1b (p=0.01) and IL-8 (p=0.05) were elevated if the female partner had BV. Conclusion To our knowledge, this is the first comparison between MSM and MSWomen of penile microbiome and urinary cytokines. Future studies should examine whether microbiome and mucosal inflammation differences between MSM and MSWomen cause differential risk of HIV/STI acquisition or differential impact on efficacy of HIV/STI interventions. Disclosure No significant relationships.