Abstract:Aim: To investigate the expression of p63 protein and ki67 antigen in a series of graded OSCC to evaluate the potential association between the expression of the two markers and the aggressiveness of histologic grades of OSCC. Methods: Hematoxylin and Eosin (H&E) and streptavidin-biotin immunoperoxidase staining techniques was used to detect the expression of p63 & ki67 in different grades of OSCC. Evaluation of immunostaining was done using computer image analyzer system & statistical analysis. Results: regar… Show more
Background:
The oral cavity is the most common site of cancer in the Indian subcontinent contributing to one-third of all cancers. The prognosis of oral dysplasia and malignant lesions can be predicted by both clinicopathological parameters and molecular markers.
Aims and Objectives:
The present study was undertaken to examine and compare the expression profile of cell cycle regulatory proteins p63 and Ki-67 in normal dysplastic and malignant lesions of oral mucosa and its correlation with prognosis.
Settings and Design:
This was a retrospective case–control study in a tertiary referral center.
Materials and Methods:
We evaluated and compared the expression profile of antigens p63 and Ki-67 on 60 cases of histologically proven oral dysplastic and malignant lesions oral squamous cell carcinoma (OSCC – 35 cases), oral epithelial dysplasia (OED – 15 cases), and 10 cases of benign and inflammatory oral lesions.
Statistical Analysis:
Mean and standard deviation were calculated and ANOVA statistical test was used to compare the data.
Results:
The mean labeling index of p63 and KI-67 was higher in OSCC than OED and minimum in inflammatory (controls) groups.
Conclusion:
p63 expression had a positive correlation with Ki-67 expression. Thus, p63 and Ki-67 may be a marker for tumorigenesis and tumor cell proliferation.
Background:
The oral cavity is the most common site of cancer in the Indian subcontinent contributing to one-third of all cancers. The prognosis of oral dysplasia and malignant lesions can be predicted by both clinicopathological parameters and molecular markers.
Aims and Objectives:
The present study was undertaken to examine and compare the expression profile of cell cycle regulatory proteins p63 and Ki-67 in normal dysplastic and malignant lesions of oral mucosa and its correlation with prognosis.
Settings and Design:
This was a retrospective case–control study in a tertiary referral center.
Materials and Methods:
We evaluated and compared the expression profile of antigens p63 and Ki-67 on 60 cases of histologically proven oral dysplastic and malignant lesions oral squamous cell carcinoma (OSCC – 35 cases), oral epithelial dysplasia (OED – 15 cases), and 10 cases of benign and inflammatory oral lesions.
Statistical Analysis:
Mean and standard deviation were calculated and ANOVA statistical test was used to compare the data.
Results:
The mean labeling index of p63 and KI-67 was higher in OSCC than OED and minimum in inflammatory (controls) groups.
Conclusion:
p63 expression had a positive correlation with Ki-67 expression. Thus, p63 and Ki-67 may be a marker for tumorigenesis and tumor cell proliferation.
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