2018
DOI: 10.18632/aging.101537
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Abstract: P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies. For example, previously we demonstrated that administration of p62/SQSTM1-encoding plasmid reduced chronic inflammation and alleviated osteoporosis and metabolic syndrome in animal models. Herein, we built upon these findings to investigate effect of the p62-encoding plasmid on an age-related macular degeneration (AMD), a progressive neurodegenerative ocular disease, using spont… Show more

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Cited by 21 publications
(20 citation statements)
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References 31 publications
(49 reference statements)
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“…This protein is widely recognized for its multiple roles in the cell and also emerged as a key factor in AD [ 30 ]. In addition, previous data demonstrated that the administration of a p62-encoding plasmid exerted a powerful anti-osteoporotic, anti-inflammatory, and retinoprotective activity in animal models [ 31 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…This protein is widely recognized for its multiple roles in the cell and also emerged as a key factor in AD [ 30 ]. In addition, previous data demonstrated that the administration of a p62-encoding plasmid exerted a powerful anti-osteoporotic, anti-inflammatory, and retinoprotective activity in animal models [ 31 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…Already by the age of ~3–4 months, 100% of OXYS rats develop clinical signs of retinopathy against the background of a reduction in the transverse area of the retinal pigment epithelium (RPE), impairment of choroidal microcirculation, and retinal thinning [ 8 ]. The progression of these abnormalities in OXYS rats with age is accompanied by a significant reduction in the thickness of the photoreceptor cell layer and a decrease in the number of photoreceptor cell nuclei in the outer nuclear layer (ONL), especially in the central part of the retina [ 9 , 10 ]. The significant pathological changes in the RPE manifest themselves as excessive accumulation of lipofuscin and amyloid in the RPE regions and disturbances in the morphology of the RPE sheet, including an increase in the proportion of multinucleated cells, hypertrophy, distortion of cell shape, and reactive gliosis [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…Of note p62 DNA treatment of patients partially restored their sensitivity to conventional chemotherapy which they previously failed . However, it remains to be revealed if the anti‐cancer activity of p62‐encoding plasmid in humans is due to a direct adaptive immune response it elicits against the over‐expressed p62 as it was originally hypothesized or if the anti‐cancer effect results from the fact that the plasmid reduces chronic inflammation as observed in animal models for osteoporosis, age‐related macular degeneration and diet‐induced obesity .…”
Section: Discussionmentioning
confidence: 98%