p53 status correlates with the risk of progression in stage T1 bladder cancer: a meta-analysis

Abstract

BackgroundPublished studies have yielded inconsistent results on the relationship between p53 status and the progression of stage T1 non-muscle invasive bladder cancer (NMIBC). Therefore, we performed a meta-analysis to evaluate the prognostic value of p53 in T1 NMIBC.MethodsWe systematically searched for relevant literatures in MEDLINE, EMBASE, and Web of Science. Data were pooled together from individual studies, and meta-analysis was performed. Study quality was assessed using the Newcastle-Ottawa Scale. Pooled risk ratios (RRs) and 95 % CI were calculated to estimate the effect sizes. Moreover, subgroup analyses were carried out.ResultsA total of 12 studies comprising 712 patients were subjected to the final analysis. p53 overexpression was significantly associated with higher progression rate of T1 NMIBC (RR 2.32, 95 % CI 1.59–3.38). Moderate heterogeneity was observed across the studies (I2 = 39 %, P < 0.0001). In a subgroup analysis stratified by stage, p53 overexpression was a predictor of progression in T1 grade 3 NMIBC (RR 2.71, 95 % CI 1.31–5.64). In addition, in a subgroup analysis stratified by intravesical therapy, p53 overexpression was a predictor of progression in T1 NMIBC received Bacillus Calmette-Guérin intravesical therapy (RR 3.35, 95 % CI 1.89–5.93). Furthermore, after excluding the study that possibly contributed to the heterogeneity by the sensitivity analysis, the association p53 overexpression was significantly correlated with progression of T1 NMIBC (RR 2.74, 95 % CI 2.05–3.65) without evidence of heterogeneity (I2 = 0 %, P < 0.0001).ConclusionsThis meta-analysis suggested that p53 overexpression may be associated with progression of T1 NMIBC patients. Because of the heterogeneity and other limitations, further studies with rigid criteria and large populations are still warranted to confirm our findings.

Impact of the Ki-67 labeling index and p53 expression status on disease-free survival in pT1 urothelial carcinoma of the bladder

“…Consequently, molecular defects in human cancer cells have been linked to pathway irregularities with inactivated p53 leading to an increased half-life of the protein and prolonged detectability via immunohistochemistry ( 11 , 12 ). This concept has been adapted and validated for urothelial cancers as well ( 13 - 15 ). Likewise, Ki-67 constitutes an established protein biomarker encoded by the MKI67 gene ( 16 ) and is necessary for cellular proliferation.…”

“…Against this backdrop, the proportion of Ki-67 positive tumor cells (i.e., the Ki-67 labeling index) is correlated with disease recurrence and progression in malignancies, and urothelial cancer in particular ( 14 , 15 , 17 ). However, not many studies focus on the expression patterns of aforementioned biomarkers in the subgroup of patients diagnosed with pT1 bladder cancer, and the available evidence is scarce and partially contradictory ( 13 , 18 - 22 ). The aim of our study was to mirror contemporary expression patterns of the p53 and Ki-67 biomarkers in a homogeneous Northern German cohort of patients with pT1 urothelial carcinoma of the bladder.…”

DHCR24 predicts poor clinicopathological features of patients with bladder cancer

“…The results of GSEA suggested that DHCR24 promoted the proliferation of BC cells through biological processes that had been reported to be involved in carcinogenesis, such as estrogen response, [ 21 ] heme metabolism, [ 22 ] P53 pathway, [ 23 , 24 ] cholesterol homeostasis, [ 25 ] mTORC1 signaling, [ 26 ] peroxisome, [ 27 ] xenobiotic metabolism, [ 28 ] glycolysis, [ 29 ] and protein secretion.…”

Clinical effects of p53 overexpression in squamous cell carcinoma of the sinonasal tract

“…[39] Some studies show that positive/high p53 expression is correlated with the development and progression of tumor in several human cancers. [40,41] However, the results of p53 expression are still inconsistent and controversial in SNSCC. Different expression levels of the p53 gene were reported in different studies, ranging from 33.3% [26] to 100% [23] in SNSCC.…”