Clinical effects of p53 overexpression in squamous cell carcinoma of the sinonasal tract

Abstract

Background:The level of p53 protein expression in sinonasal squamous cell carcinoma (SNSCC) has been estimated, but the results remain inconsistent and the point of consensus has not been reached. This study was first determined to evaluate the clinical effects of p53 expression in SCC of the sinonasal tract.Methods:According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria, the potential literature was searched from diverse databases. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to assess the strength of association between p53 expression and SNSCC.Results:Final 17 eligible studies were included in a total of 258 cases and 748 controls. The result of p53 expression was shown to be notably higher in SNSCC than in benign sinonasal papillomas and normal sinonasal mucosa (OR = 26.93, P < 0.001; OR = 39.79, P < 0.001; respectively). Subgroup analyses of ethnicity revealed that p53 expression had significant association with SNSCC in Asian and Caucasian populations in cancer versus benign sinonasal papillomas or normal sinonasal mucosa. The expression of p53 was notably higher in moderately or poorly differentiated SNSCC than in well-differentiated SNSCC (OR = 3.51, P = 0.021), while p53 expression was not associated with histological type.Conclusion:The results suggested that p53 overexpression may be correlated with the carcinogenesis and progression of SNSCC. The p53 gene may become a novel drug target of SNSCC. Additional studies on the correlation of p53 expression with clinicopathological features are needed.

A Novel LncRNA, AC091729.7 Promotes Sinonasal Squamous Cell Carcinomas Proliferation and Invasion Through Binding SRSF2

“…A previous study reported that high expression of TrkB plays a major role in SNSCC, and TrkB can be used as a potential prognostic indicator for the clinical prognosis (25). Another report identified that p53 overexpression might be related to the occurrence and development of SNSCC (26). A study by Kovarikova et al (27) suggested that the upregulation of miR-21 was involved in the occurrence and prognosis of sinonasal carcinoma.…”

From Cancer to Rejuvenation: Incomplete Regeneration as the Missing Link (Part II: Rejuvenation circle)

“…The same happens in embryogenesis, where Mdm2 is critically required, and unrestrained p53 activity during development causes early embryonic lethality, as occurs upon loss of the p53-negative regulators Mdm2 or Mdmx [59]. At the same time, as it is known, the overexpression of P53 correlates with carcinogenesis and is an early event in the development of some human carcinomas [60][61][62][63].…”

Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside

“…Vital et al demonstrated an aberrant staining pattern in 60% of their cohort of SCC of the nasal vestibule, which was associated with worse DFS [82]. Wang et al found higher p53 expression in SNSCC compared with benign papillomas and normal mucosa, which was associated with poor to moderate differentiation [83].…”