p53 Protein Expression in Esophageal Squamous Cell Papillomas: A Study of 36 Lesions

Poljak, Mario; Cerar, Anton; Orłowska, Janina

doi:10.3109/00365529609031620

Cited by 25 publications

(34 citation statements)

References 13 publications

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“…The hot debate is whether or not the squamous cell carcinoma is caused by human papilloma virus. Some researchers insisted the association of squamous papilloma and human papilloma virus [5, 7, 8], but others denied the association [6]. In the present study, although no viral examination was performed, koilocytosis as seen in uterine cervix neoplasm and condyloma acuminatum was not recognized.…”

Section: Discussioncontrasting

confidence: 55%

Benign Tumors of the Esophagus: A Histopathologic Study of 49 Cases among 931 Consecutive Esophageal Biopsies

Terada

2009

Gastroen Res

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The author reviewed 931 consecutive esophageal biopsies in the last 15 year in out pathology laboratory of our hospital in search for benign esophageal tumors. As the results, 41 cases (4.4%) of squamous papilloma, 4 cases (0.4%) of granular cell tumor, 3 cases (0.3%) of leiomyoima, and 1 case (0.1%) tubular adenoma were identified. The 41 cases of squamous papillma were located in the cervical esophagus in 6 cases, in the proximal esophagus in 12 cases, in the middle esophagus in 11 cases, and in the distal esophagus in 12 cases. The squamous papilloma was immunohistochemically positive for various cytokeratins. It was endoscopically recognized as small polypoid tumor. The age ranged from 35 years to 81 years with a mean of 51 years. Male to female ratio was 25:16. The 4 cases of granular cell tumor were located in the proximal esophagus in 3 cases, and in the middle esophagus in 1 case. The granular cell tumor was immunohistochemically positive for vimentin, S100 protein, and neuron-specific enolase. It was endoscopically recognized by elevated small lesions. The ages of were 36, 45, 67 and 78 years, and male to female ratio was 1:3. The 1 case of tubular adenoma was located in the distal esophagus. Histologically, it was associated with heterotopic gastric mcusa, and immunohistochemically faintly positive for p53 protein and Ki-67 antigen. It was endoscopically a slightly elevated lesion. The patient was 46 year-old man. The 3 cases of leiomyoma were located in the cervical esophagus in 1 case and in the proximal esophagus in 2 cases. It was immunohistochemically positive for vimentin, α-smooth muscle actin, and desmin. It was endoscopically recognized as a submucosal tumor. The ages were 34, 45, and 85 years. Male to female ratio was 1:2.

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Section: Discussioncontrasting

confidence: 55%

Benign Tumors of the Esophagus: A Histopathologic Study of 49 Cases among 931 Consecutive Esophageal Biopsies

Terada

2009

Gastroen Res

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“…It has been widely studied in gynecological cancers, mostly in cervical cancers. In esophageal SCP, genotype 6 HPV, which has lower oncogenic risk profile, is mainly detected (12)(13)(14). In our study, amongst the 38 SCPs analyzed, 7 (19%) were positive for HPV DNA (5 males and 2 females); 3 SCPs were of genotype 6, whereas 4 were of genotypes 16, 18, 31, and 81 that are known to have high oncogenic potential.…”

Section: Discussionmentioning

confidence: 83%

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

Tıftıkcı

Kutsal²,

Altıok³

et al. 2017

Turk J Gastroenterol

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Background/Aims: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV. Materials and Methods: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals. Slides from each patient were reviewed and samples with satisfactory papilloma tissues were submitted to molecular analysis. DNA has been isolated. DNA sequencing has been performed for genotyping HPV for all types. Results: Our study group consisted of 21 women and 17 men (a total of 38 patients), mean age was 41 years (range 17-67 years). Most of the papillomas were located at mid-esophagus (68%). Eight out of 38 patients (21%) had associated erosive esophagitis, and fourteen patients (36.8%) had Helicobacter Pylori (H. pylori). Of the 38 SCP analyzed, seven (19%) were positive for HPV DNA. Three of them were of genotype 6, whereas four were of genotype 16, 18, 31, 81 that are known as highly oncogenic. There were no correlations between the presence of HPV and the patient's age, the presence of reflux esophagitis or H. pylori, smoking habit and the location of the papillomas. Conclusion: The presence of high-risk type HPV in esophageal SCP may implicate a role of the virus in the pathogenesis of the esophageal tumor.

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“…Interestingly, p53 seems to be mutated even in early precancer lesions, at least in the high risk area of China, 135 although p53 mutations are exceptional in benign SCPs. 136 The presence of frequent mutations of the p53 gene in both HPV positive and HPV negative carcinomas suggests an important role for environmental carcinogens in oesophageal carcinogenesis. 20 93 104 132 133 135-140 Recently, several HPV-16 and HPV-18 positive cells lines from oesophageal SCCs have been established, 92 and have been used to study HPV replication.…”

Section: In Vitro Studiesmentioning

confidence: 99%

HPV infections and oesophageal cancer

Syrjänen

2002

Journal of Clinical Pathology

248

294

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p53 Protein Expression in Esophageal Squamous Cell Papillomas: A Study of 36 Lesions

Abstract: We speculate that these findings are the result of immunohistochemical detection of the stabilized wild-type p53 protein rather then mutated p53 protein.

Cited by 25 publications

References 13 publications

Benign Tumors of the Esophagus: A Histopathologic Study of 49 Cases among 931 Consecutive Esophageal Biopsies

Benign Tumors of the Esophagus: A Histopathologic Study of 49 Cases among 931 Consecutive Esophageal Biopsies

Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

HPV infections and oesophageal cancer

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