Analyzing esophageal squamous cell papillomas for the presence of human papilloma virus

Abstract

Background/Aims: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV. Materials and Methods: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals. Slides from each patient were reviewed and samples with satisfactory papilloma tissues were submitted to molecular analysis. DNA has been isolated. DNA sequencing has been performed for genotyping HPV for all types. Results: Our study group consisted of 21 women and 17 men (a total of 38 patients), mean age was 41 years (range 17-67 years). Most of the papillomas were located at mid-esophagus (68%). Eight out of 38 patients (21%) had associated erosive esophagitis, and fourteen patients (36.8%) had Helicobacter Pylori (H. pylori). Of the 38 SCP analyzed, seven (19%) were positive for HPV DNA. Three of them were of genotype 6, whereas four were of genotype 16, 18, 31, 81 that are known as highly oncogenic. There were no correlations between the presence of HPV and the patient's age, the presence of reflux esophagitis or H. pylori, smoking habit and the location of the papillomas. Conclusion: The presence of high-risk type HPV in esophageal SCP may implicate a role of the virus in the pathogenesis of the esophageal tumor.

Esophageal squamous papilloma: A case series and literature review

“…A study of 38 patients with ESP from Turkey identified seven lesions infected with HPV. Of them, four were low risk (types 6 and 81) and three were high risk (types 16, 18 and 31) . In a smaller study in Mexico, there were 14 HPV‐positive ESPs, of which 10 were infected with low‐risk HPV (types 6 and 11) and two were infected with high‐risk HPV (type 16) .…”

“…Of them, four were low risk (types 6 and 81) and three were high risk (types 16, 18 and 31). 7 In a smaller study in Mexico, there were 14 HPV-positive ESPs, of which 10 were infected with low-risk HPV (types 6 and 11) and two were infected with high-risk HPV (type 16). 8 More data are needed to better understand the patterns of HPV infection in ESPs as well as their potential oncogenic role.…”

Human papillomavirus infection in esophageal squamous cell carcinoma and esophageal adenocarcinoma: a concise review

“…More recently, Tiftikçi et al 21 analyzed esophageal SCPs for the presence of HPV. Patients with a definite diagnosis of SCP of the esophagus were identified from pathology records for a 2-year period.…”

infecção do HPV como fator de risco para o carcinoma de células escamosas de esôfago e seu prognóstico

“…E sophageal cancer is the eighth most common cause of cancer and the sixth most common cancer-related death 1 . In Brazil, excluding non-melanoma skin cancer, it is the sixth most incident among men and thirteenth among women 2 .…”

“…Its prognosis is poor, with a survival rate of around 20% over five years. The most common histological type in the world is still squamous cell carcinoma, with geographical and ethnic variations, followed by adenocarcinoma 1 . The risk factors for the development of esophageal squamous cell carcinoma are not well defined, with the use of alcohol and tobacco accountable as the main etiological factors.…”