P53 Protein Expression in Eccrine Poroma and Porocarcinoma

Abstract

The role of p53 mutation has been shown in different human malignancies, including various skin cancers. In this study, we examined p53 protein expression in 25 eccrine poromas and 11 porocarcinomas by immunohistochemistry. P53 expression was observed in 88% (22 of 25) of eccrine poromas and 73% (8 of 11) of porocarcinomas. In eccrine poromas, percentage of cells reactive for p53 was less than 5% (low expresser) in 6 cases, 5 to 50% (moderate expresser) in 14 and greater than 50% (high expresser) in 2 cases. In terms of intensity, 13 cases showed weak staining, 8 moderate, and 1 case showed strong reactivity. On the other hand, 2 cases of porocarcinoma were low expresser, 2 were moderate and 4 were high expresser. All of the high expressers had also strong staining. This study has demonstrated that eccrine poromas showed significant p53 expression as much as porocarcinomas and, therefore, p53 positivity cannot be accepted as a valuable parameter for malignancy. P53 gene may involve in the carcinogenetic pathway of porocarcinoma but it is likely that other oncogenes may also have a role.

Multiple eccrine poromas in the setting of total body irradiation and immunosuppression

“…Limited prior studies have focused on the status of selected tumor suppressor genes, including p53, the adenomatous polyposis coli gene, p16, and the retinoblastoma gene. [14][15][16][17] However, these studies do not identify any defining genetic aberration. Thus a more broad-based molecular approach may be necessary to fully elucidate specific gene defects involved in eccrine poroma tumorigenesis.…”

Eccrine porocarcinoma of the lower extremity: A case report and review of literature

“…It seems that the upper portion of the dermal eccrine duct could have a role in the oncogenesis. More recently, the p53 gene involved in tumor suppressing, could be involved in EPC carcinogenesis [19]. Throughout the literature search, there is not a definite time line in which a poroma advances and becomes a porocarcinoma.…”

Porocarcinoma écrino: relato de quatro casos e revisão da literatura

“…Mais recentemente, sugeriu-se que uma mutação no gene supressor tumoral, o P53, poderia estar envolvido na carcinogênese do PCE. 8 Muitos pacientes notaram a lesão primária anos antes do diagnóstico. Isso reforça o fato de que muitos PCE podem originar-se de um PE.…”