p53 Overexpression as a marker of malignancy in gastric biopsies

Starzyńska, Teresa; Marsh, P J; Stern, Peter L.

doi:10.1016/0960-7404(93)90062-4

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Immunohistochemical profiles of equivocally appearing glands are often useful in differential diagnosis. Overexpression of p53 reaches approximately 40% in gastric adenocarcinomas 20 . The expression of p53 may be used to improve the diagnostic accuracy of gastric biopsy for carcinomas, 20 including EWDA 1 .…”

Section: Discussionmentioning

confidence: 99%

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Extremely well‐differentiated adenocarcinoma of the gastric cardia: A unique case with columnar cells and laminated stones

Kawanowa

Kawata

Hanatsuka

et al. 2004

Pathology International

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Extremely well-differentiated adenocarcinoma (EWDA) is an unusual gastric cancer that is histologically too bland to be diagnosed as malignant neoplasm, particularly using biopsy. EWDA may be a gastric counterpart of 'adenoma malignum' or minimal deviation adenocarcinoma (MDA) in the uterine cervix; however, the clinicopathological features of EWDA remain less apparent than those of MDA. A 60-year-old male was complaining of dysphagia. He had been made aware of a small submucosal tumor in the cardia 2 years before the onset of this symptom. Endoscopic ultrasonographic examination revealed a large cardiac tumor consisting of thickened layers, as observed in Borrmann type IV. Three mucosal biopsies suggested only benign changes including adenoma and hyperplastic polyps. At the fourth biopsy, cytologically bland columnar cells were located in the submucosa along with stromal fibrosis and laminated stones. The possibility that non-neoplastic aberrant pancreas with lithiasis formed the tumor was denied at laparotomy by a frozen section that revealed benign-looking glands invading the diaphragm. Immunohistochemically the cancer glands were positive for CA19-9 and human gastric mucin, but not for p53 or MUC2. To our knowledge, this is a previously unknown combination of EWDA and psammomatous calcification in the stomach.

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Section: Discussionmentioning

confidence: 99%

“…Overexpression of p53 reaches approximately 40% in gastric adenocarcinomas. 20 The expression of p53 may be used to improve the diagnostic accuracy of gastric biopsy for carcinomas, 20 including EWDA. 1 Unfortunately overexpres-…”

Section: Discussionmentioning

confidence: 99%

Extremely well‐differentiated adenocarcinoma of the gastric cardia: A unique case with columnar cells and laminated stones

Kawanowa

Kawata

Hanatsuka

et al. 2004

Pathology International

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Study on the p53 protein expression in gastric cancer and precancerous lesions by flow cytometry

Ying

Zhang

1996

Journal of Tongji Medical University

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Editorial: Genomania of p53 Protein in Gastric Cancer

Triantafillou¹,

Grosman²,

Verma³

1996

Journal of Clinical Gastroenterology

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The role of oncogenes and tumor suppressor genes in the pathogenesis of gastric cancer has recently received considerable attention. p53 is a tumor suppressor gene that is essential in the cell cycle; it prevents G1/S phase transition, after exposure to ionizing radiation or DNA-damaging chemotherapy. This allows the cell to repair its DNA or, if the damage is irreversible, to elicit apoptotic cell death. p53 mutations are seen in many human tumors including gastric carcinoma. Evidence suggests that mutant p53 is associated with shorter life expectancy in gastric, breast, lung, and colorectal cancer. A number of studies have shown cellular resistance to chemotherapy in the presence of mutant p53. Currently, increasing interest has been devoted to the potential role of mutant p53 as a screening tool.

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p53 Overexpression as a marker of malignancy in gastric biopsies

Cited by 4 publications

References 15 publications

Extremely well‐differentiated adenocarcinoma of the gastric cardia: A unique case with columnar cells and laminated stones

Extremely well‐differentiated adenocarcinoma of the gastric cardia: A unique case with columnar cells and laminated stones

Study on the p53 protein expression in gastric cancer and precancerous lesions by flow cytometry

Editorial: Genomania of p53 Protein in Gastric Cancer

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