P480 The effect of adjuvant therapy (Sinergin®) in induction and maintaining remission in mild and moderate IBD

Ichim, Simona; Dimitriu, Anca; Gheorghe, Cristian; Diculescu, Mircea; Mateescu, Bogdan; Prelipcean, Cristina Cijevschi; Gheorghe, Liana

doi:10.1093/ecco-jcc/jjy222.604

Cited by 2 publications

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“…For ulcerative colitis (UC), a Japanese RCT with 40 participants found the FOS 1-kestose at 10 g/day to be superior to a maltose placebo for the induction of clinical remission [ 121 ]. Three RCTs did not otherwise find a difference between oligofructose-enriched inulin (OF-IN) at 10–12 g/day with their respective controls (OF-IN at 7.5 g/day, maltodextrin placebo, no intervention) for the induction of clinical remission [ 122 , 123 , 124 ]. There was nonetheless a reduction in fecal calprotectin concentrations observed in two of the RCTs with OF-IN at 12–15 g/day but not with the lower-dose OF-IN at 7.5 g/day or maltodextrin placebo [ 122 , 123 ].…”

Section: Role Of Prebiotics and Probiotics For Various Gastrointestin...mentioning

confidence: 99%

Prebiotics and Probiotics for Gastrointestinal Disorders

Rau,

Gregg,

Yaceczko

et al. 2024

Nutrients

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The complex role of the gut microbiome in the pathogenesis of gastrointestinal (GI) disorders is an emerging area of research, and there is considerable interest in understanding how diet can alter the composition and function of the microbiome. Prebiotics and probiotics have been shown to beneficially modulate the gut microbiome, which underlies their potential for benefit in GI conditions. Formulating specific recommendations for the public regarding these dietary supplements has been difficult due to the significant heterogeneity between strains, doses, and duration of treatment investigated across studies, as well as safety concerns with administering live organisms. This review aims to summarize the existing evidence for the use of prebiotics and probiotics in various GI disorders, paying special attention to strain-specific effects that emerged and any adverse effects noted.

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Section: Role Of Prebiotics and Probiotics For Various Gastrointestin...mentioning

confidence: 99%

Prebiotics and Probiotics for Gastrointestinal Disorders

Rau,

Gregg,

Yaceczko

et al. 2024

Nutrients

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Prebiotics for Induction and Maintenance of Remission in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis

Limketkai,

Godoy-Brewer,

Shah

et al. 2024

Inflammatory Bowel Diseases

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Background Prebiotics are nondigestible carbohydrates fermented by gut bacteria into metabolites that confer health benefits. However, evidence on their role for inflammatory bowel disease (IBD) is unclear. This study systematically evaluated the research on prebiotics for treatment of IBD. Methods A search was performed in PubMed, Embase, Cochrane, and Web of Science. Eligible articles included randomized controlled trials or prospective observational studies that compared a prebiotic with a placebo or lower-dose control in patients with IBD. Meta-analyses were performed using random-effects models for the outcomes of clinical remission, clinical relapse, and adverse events. Results Seventeen studies were included. For induction of clinical remission in ulcerative colitis (UC), the fructooligosaccharide (FOS) kestose was effective (relative risk, 2.75, 95% confidence interval, 1.05-7.20; n = 40), but oligofructose-enriched inulin (OF-IN) and lactulose were not. For maintenance of remission in UC, germinated barley foodstuff trended toward preventing clinical relapse (relative risk, 0.40; 95% confidence interval, 0.15-1.03; n = 59), but OF-IN, oat bran, and Plantago ovata did not. For Crohn’s disease, OF-IN and lactulose were no different than controls for induction of remission, and FOS was no different than controls for maintenance of remission. Flatulence and bloating were more common with OF-IN; reported adverse events were otherwise similar to controls for other prebiotics. Conclusion Prebiotics, particularly FOS and germinated barley foodstuff, show potential as effective and safe dietary supplements for induction and maintenance of remission in UC, respectively. The overall certainty of evidence was very low. There would be benefit in further investigation on the role of prebiotics as treatment adjuncts for IBD.

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P480 The effect of adjuvant therapy (Sinergin®) in induction and maintaining remission in mild and moderate IBD

Cited by 2 publications

References 0 publications

Prebiotics and Probiotics for Gastrointestinal Disorders

Prebiotics and Probiotics for Gastrointestinal Disorders

Prebiotics for Induction and Maintenance of Remission in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis

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