P428 New opportunities overcoming of the secondary inefficiencies of the anticytokine therapy in patients with inflammatory bowel disease

Stem Cell Therapy in the Treatment of Inflammatory Bowel Disease

“…The level of anticytokine drugs antibodies was shown to correlate with the severity of clinical and endoscopic picture [12]. CT was also reported to decrease the need for glucocorticosteroid therapy and other drugs, what results in the decrease of treatment cost [28].…”

“…The efficiency of conventional methods of UC and CD treatment leaves much to be desired [1,[9][10][11]. Modern therapy of IBD includes biological therapy (antibodies to TNF-α, adhesion molecules, IL-12/23, IL-6R, endoscopic application of artificially grown pieces of tissues etc) and gene therapy (iRNA-technologies aimed at inhibition of the necessary genes) [2,3,7,12,13]. The application of nanoparticles for the transportation of drugs despite its high cost is also promising [2].…”

“…potential and effectiveness of SC in the treatment of UC and CD [7,[9][10][11]14,15]. According to experts' prognoses, CT will become the next generation of therapeutic arrangements in the treatment of IBD, in particular for patients with the secondary resistance to anticytokine therapy [4,12].…”

Cell therapy in gastroenterology

“…Therefore, the 1 and 2 phases of clinical studies have confirmed the safety of cell therapy in the treatment of the colon disorders and its advantages over the use of fibrin glue in patients with fistulas [31,33]. As mentioned above, cell therapy is particularly important for patients refractory to anticytokine drugs [14].…”

“…Also cell therapy is considered to be the next generation of therapeutic interventions in the treatment of systemic inflammatory diseases of the colon, especially for patients with secondary resistance to anticytokine therapy [14,22]. Today significant clinical experience of stem cells application in the treatment of liver failure and pancreatic disorders as well as genetically mediated diseases of the intestine, including celiac disease has been accumulated [5,11,16,24,29].…”