Cell therapy in gastroenterology

Nasadyuk, C. M.

doi:10.22494/cot.v3i1.25

Cited by 3 publications

(3 citation statements)

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“…Due to immunosuppressive properties of the mesenchymal stem cells, cell therapy is regarded as a perspective method of treatment of the type 1 diabetes mellitus. And the ability of umbilical cord MSCs to produce numerous growth factors as the treatment of systemic inflammatory diseases of the colon, especially in patients with secondary resistance to anti-cytokine therapy [18,26].…”

Section: The Application Of the Umbilical Cord Mscs In The Treatment mentioning

confidence: 99%

“…Application of the MSCs in systemic inflammatory disorders of the colon was shown to decrease pain syndrome, diarrhea and bleeding and to stimulate reparation processes [25,26,27,28]. The first and second phases of clinical trials proved the safety of mesenchymal stem cells administration in the treatment of Crohn's disease and ulcerative colitis and their advantages compared to the use of fibrin glue in fistulizing colitis [18,27,29].…”

Section: The Application Of the Umbilical Cord Mscs In The Treatment mentioning

confidence: 99%

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Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Nasadyuk¹

2016

JCOT

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Due to the prominent immunosuppressive and regenerative properties, umbilical cord mesenchymal stem cells are the most widely explored in the treatment of autoimmune diseases and posttransplant complications as well as for the facilitation of engraftment of hematopoietic stem cell transplant and cell culturing in vitro. The review presents modern immunophenotypic characterization of the umbilical cord mesenchymal stem cells, approaches to isolation, biobanking, and clinical application.

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Section: The Application Of the Umbilical Cord Mscs In The Treatment mentioning

confidence: 99%

Section: The Application Of the Umbilical Cord Mscs In The Treatment mentioning

confidence: 99%

Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Nasadyuk¹

2016

JCOT

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“…Peptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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IntroductionPeptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users. Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. DiscussionDue to the modern outlook, regulatory peptides are considered to be phylogenetically the oldest form of bioregulation [13][14][15][16][17][18][19][20][21]. Thus, the mechanisms of peptidergic regulation of homeostasis open huge perspectives for the creation of the essentially new methods for the prevention and treatment of different diseases [13][14][15][16]. Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives -oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21].The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. For example, it was shown that the inhibition of pancreatic juice secretion by 28-amino acidscontaining hormone ghrelin is realized by its biologically active part -pentapeptide with the sequence of amino acids Gly-Ser-Ser (n-octanoyl)-Phe [23].The advantages of the short peptides above their long-chain derivatives are high biological activity, that often many fold exceeds the activity of the peptide-precursor, high tissue specificity, lack of species specificity and lack of immunogenicity [13,14,[15][16][17][18]20,21]. It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13][14][15][16][17][18][19][20][21]. The interaction with DNA was proposed to be the key moment of the realization of the biological effect of the short peptides [17][18][19]21]. This concept is s...

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Legislative regulation of the banking of umbilical cord blood stem cells, other human cells and tissues and clinical trials with their use in the different countries of the world

Nasadyuk¹,

Makhinya²,

Shabliy³

et al. 2016

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The article highlights the experience and peculiarities of legislative regulation of umbilical cord blood and tissue banking in the different countries of the world as well as clinical trials with their application. The approaches to licensing and legislative regulation of the business activities of the cord blood banks in Ukraine are also described. KEYWORDS: stem cells, umbilical cord blood, bank of umbilical cord blood, legislative regulation.REVIEW of 2014 made about 90 % from the total number of transplants performed from the moment of the first cord blood application in 1988 [15]. From 1988 to 2014, 53 % of cord blood transplants were performed in children and 43 % operations -in adults. However, from 2008 number of umbilical cord blood transplants in adults annually over exceeds their quantity in children [15,16]. Also researchers and clinicians of the field express increasing interest to the mesenchymal stem cells of the placenta, umbilical cord, adipose tissue, teeth pulp, menstrual blood [12,14, 24,26]. The approaches to the treatment of musculoskeletal system injuries with the use of tenocytes cultures are being developed [14]. In particular, Ukrainian scientists from the Institute of Cell Therapy and Romodanov Institute of Neurosurgery of AMSU developed the technology of the treatment of herniated discs using cultivated autologous chondrocytes [17].Because of the mentioned above tendencies of the world medicine, collection and processing of cellular material for the clinical purposes is considered to be as a unique method of the manufacturing of biologics, that implicate strict following of the determined rules for the provision of the high quality of the drug and avoiding contamination with microorganisms or cells of the other patient/donor. Manufacturing of cell drugs, processing, testing and cryostorage of tissues are strictly regulated by numerous international documents and should match the demands of the standards of Current Good Tissue Practice (сGTP) and Good Manufacturing Practice (GMP) [1,2].

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Cell therapy in gastroenterology

Abstract: ABSTRACT

Cited by 3 publications

References 29 publications

Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Umbilical cord stem cells: biological characteristics, approaches to banking and clinical application

Gastroprotective Oligopeptides

Legislative regulation of the banking of umbilical cord blood stem cells, other human cells and tissues and clinical trials with their use in the different countries of the world

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