P3I-5 Study on SAW Characteristics of Amorphous- TeO2/128&amp;#x000B0;Y-X LiNbO3 Structures

Shang, Xiaoli; Gong, Xun; Xiong, Jun; Tong, Tangji; De, Zhang

doi:10.1109/ultsym.2007.476

Cited by 3 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…Ma et al [7] found that GYII and its disassembled blood activation prescription (BAP) could inhibit tumor formation by mediating autophagy and apoptosis in human breast cancer cell line MCF-7 xenograft tumor. Zhang et al [6] confirmed that GYII and its disassembled prescriptions can inhibit breast tumor growth and metastasis, and are related to the reducing the levels of p-ERK and phosphorylated protein kinase B (p-AKT). In recent years, the research on the mechanism of the antitumor effect of GYII and its effective components has been gradually deepened.…”

Section: Introductionmentioning

confidence: 99%

“…Traditional Chinese medicine (TCM) is usually applied in the form of formulated herbal mixtures in the treatment of cancer [5]. The Gubenyiliu II (GYII) was developed based on the theories of yi-qi (supplementing energy), huo-xue-hua-yu (removing blood stasis) and jie-du-san-jie (neutralizing tumor toxicity and resolving tumor) [6]. Following the theory of TCM, GYII was distributed into disassembled prescriptions, Quxie (QX) and Fuzheng (FZ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Gubenyiliu formula II and its disassembled prescriptions on cell autophagy in breast cancer through PI3K/AKT/mTOR pathway

et al. 2023

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The aim of this study is to reveal the mechanism of Gubenyiliu II (GYII) inhibiting autophagy in breast cancer and the effect of its disassembled prescriptions, Quxie (QX) and Fuzheng (FZ), which cause autophagy difference on tumor growth. After a breast cancer in situ tumor model was established, mice were randomly distributed into different groups: model, GYII, QX, FZ and tamoxifen groups, and treated correspondingly. Then, the tumor volumes and weights were monitored. Immunohistochemistry detected the contents of microtubule-associated protein light chain 3 (LC3), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) in tumor tissues. Furthermore, 4T1 cells were administrated with the 20% contained serum. Cell proliferation, migration and invasion were measured using cell counting kit-8 and transwell assays. Electron microscopy and flow cytometry detected autophagy and apoptosis. The content of LC3 was measured by immunofluorescence. Western blot detected the protein levels of LC3, Beclin1, p-PI3K/PI3K, p-AKT/AKT and p-mTOR/mTOR in tumor tissues and 4T1 cells. GYII, QX and FZ treatment significantly reduced the tumor volumes and weights in breast cancer tumor-bearing mice. The cell proliferation, migration and invasion were restrained, and cell apoptosis and autophagy were promoted in GYII, QX and FZ groups. Moreover, GYII, QX and FZ increased the expression of LC3 in 4T1 cells and tumor tissues and decreased the phosphorylation levels of PI3K, AKT and mTOR in tumor tissues. The protein levels of LC3 and Beclin1 were upregulated, and p-PI3K/PI3K, p-AKT/AKT and p-mTOR/mTOR were downregulated in tumor tissues and 4T1 cells of treatment groups. Our study confirmed that GYII could treat breast cancer by restraining the PI3K/AKT/mTOR signaling pathway-mediated autophagy. While QX focuses on inhibiting tumor growth, FZ acts on inhibiting tumor metastasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Gubenyiliu formula II and its disassembled prescriptions on cell autophagy in breast cancer through PI3K/AKT/mTOR pathway

et al. 2023

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Effects of TeOx films on temperature coefficients of delay of Love-type wave devices based on TeOx/36°YX-LiTaO3 structures

Zhou¹,

Li²,

Fan³

et al. 2010

Vacuum

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Temperature stable amorphous-TeO2∕36°–46° Y-X LiTaO3 substrates for surface acoustic wave applications

Shang

Gong

Xiong

et al. 2008

Applied Physics Letters

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This research investigated the temperature coefficient of delay (TCD) of the surface acoustic wave (SAW) on the amorphous TeO2∕36°–46° Y-X LiTaO3 layered substrates. The TCD can reach zero when the thickness of amorphous TeO2 film is much less than that of conventional SiO2 film, which means SAW devices on such substrates can be fabricated easily. Theoretical calculation showed that they have a very high K2 around 8%, a pure transverse surface wave mode, and a zero TCD simultaneously. They are therefore very appealing for a wide range of SAW applications.

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P3I-5 Study on SAW Characteristics of Amorphous- TeO2/128°Y-X LiNbO3 Structures

Cited by 3 publications

References 6 publications

Effect of Gubenyiliu formula II and its disassembled prescriptions on cell autophagy in breast cancer through PI3K/AKT/mTOR pathway

Effect of Gubenyiliu formula II and its disassembled prescriptions on cell autophagy in breast cancer through PI3K/AKT/mTOR pathway

Effects of TeOx films on temperature coefficients of delay of Love-type wave devices based on TeOx/36°YX-LiTaO3 structures

Temperature stable amorphous-TeO2∕36°–46° Y-X LiTaO3 substrates for surface acoustic wave applications

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