P349Platelet turnover in ST segment myocardial infarction: regulation, kinetics and clinical impact

Risk of bradyarrhythmia related to ticagrelor: A systematic review and meta-analysis

“…Among the fifteen included RCTs, ten were phase III trials (6-8, 13, 55-57, 59, 60, 62), four phase IV trials (58,61,63,64) , and one was a phase II trial (28). Nine studies were doubleblind (6-8, 13, 28, 55, 56, 59, 60, 62), 14 studies were parallel studies (6-8, 13, 55-64), one cross-over study (28).…”

“…Four studies had a follow-up period of less than 12 months (between 1 month and 6 months) (6,59,61,62), while the other eleven studies had a follow-up period comprised between twelve and 48 months (7, 8, 13, 28, 55-58, 60, 63, 64). Two studies were placebo-controlled (7,56), while the others were active comparator-controlled, eleven with clopidogrel (6,8,13,28,57,58,(60)(61)(62)(63)(64), and two with aspirin (55,59). Six studies did not included patients at-risk with previous bradycardia (7,8,13,55,57,62).…”

“…The cross-over trial did not report any wash-out period, thus with a high risk of persistence of the pharmacological effects (28); thus it was judged as a high risk for other bias. Another study was judged as unclear risk of other bias it was reported only via a congress proceeding (64) (fig 2). More than 60% of the studies were funded by industries (6-8, 13, 28, 59, 60), while funding statement was not mentioned or unclear in four study (61)(62)(63)(64).…”

“…Another study was judged as unclear risk of other bias it was reported only via a congress proceeding (64) (fig 2). More than 60% of the studies were funded by industries (6-8, 13, 28, 59, 60), while funding statement was not mentioned or unclear in four study (61)(62)(63)(64).…”

“…A total of 1,488 bradyarrhythmias were reported, 759 in ticagrelor 90 mg/BID group, and 729 in comparator(s) groups. For seven studies bradyarrhythmia events were directly extracted from the full text article, for four studies were extracted from clinicaltrial.gov (7,28,56,59,60), while for one study they were directly provided by the principal author (64). For three studies, the number of bradyarrhythmias was calculated by adding different safety events (e.g.…”