P300 Wave Changes in Patients with Multiple Sclerosis

Abstract

Introduction:In patients with multiple sclerosis among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes.Goal:The aim of this study was to demonstrate that patients with multiple sclerosis have reduced amplitude and prolonged latency, longer than 300 ± 10 ms.Methods:The study included group of patients with multiple sclerosis and control group. After reviewing the medical records both groups of 14 participants were subjected to the same testing procedures auditory cognitive potentials (P300).Results:We have shown that patients with multiple sclerosis don’t have prolonged P300 target stimulus latency, but they have a longer P300 frequent stimulus latency for 18 ms. From 14 patients seven had a pathological P300 target stimulus amplitude, and even 12 patient had pathological P300 frequent stimulus amplitude.Conclusion:People with multiple sclerosis have altered P300 which indicates the presence of cognitive dysfunction in these patients.

Magnetoencephalography and High-Density Electroencephalography Study of Acoustic Event Related Potentials in Early Stage of Multiple Sclerosis: A Pilot Study on Cognitive Impairment and Fatigue

“…Due to the ease of recording and reliability, the P300 has become the most studied endogenous ERPs component. Results of many ERPs studies are consistent with prolonged P300 latencies [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] and/or smaller P300 amplitudes [ 30 , 33 , 36 ] in 50–65% of pwMS [ 38 ]. Significant correlations are reported between prolonged P300 latency and poorer scores on neuropsychological tests, as BRB, Mini Mental State Examination (MMSE), Wechsler adult intelligence scale (WAIS), and others [ 30 , 32 , 34 , 37 ], Expanded Disability Status Scale (EDSS) scores [ 31 , 35 , 36 , 37 ], disease duration [ 31 ] and Magnetic Resonance Imaging (MRI) lesion load [ 32 , 37 ].…”

“…Previous data from literature [ 30 , 33 , 36 ] have shown the prolonged latency of P300 in pwMS and its correlation with CI; only in one work, however [ 27 ], patients at the early stages of the disease, such as those diagnosed with CIS with the older McDonald’s criteria [ 57 ] were considered, among others, confirming P300 latency prolongation in the whole MS group. In our work, instead, the latency of P300 was prolonged but remained within normal limits.…”

Magnetoencephalography and High-Density Electroencephalography Study of Acoustic Event Related Potentials in Early Stage of Multiple Sclerosis: A Pilot Study on Cognitive Impairment and Fatigue

“…Due to the ease of recording and reliability, the P300 has become the most studied endogenous ERPs component. Results of many ERPs studies are consistent with prolonged P300 latencies [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] and/or smaller P300 amplitudes [ 30 , 33 , 36 ] in 50–65% of pwMS [ 38 ]. Significant correlations are reported between prolonged P300 latency and poorer scores on neuropsychological tests, as BRB, Mini Mental State Examination (MMSE), Wechsler adult intelligence scale (WAIS), and others [ 30 , 32 , 34 , 37 ], Expanded Disability Status Scale (EDSS) scores [ 31 , 35 , 36 , 37 ], disease duration [ 31 ] and Magnetic Resonance Imaging (MRI) lesion load [ 32 , 37 ].…”

“…Previous data from literature [ 30 , 33 , 36 ] have shown the prolonged latency of P300 in pwMS and its correlation with CI; only in one work, however [ 27 ], patients at the early stages of the disease, such as those diagnosed with CIS with the older McDonald’s criteria [ 57 ] were considered, among others, confirming P300 latency prolongation in the whole MS group. In our work, instead, the latency of P300 was prolonged but remained within normal limits.…”

Speech discrimination impairments as a marker of disease severity in multiple sclerosis

“…Parallels can be drawn to our SiN tasks: background noise forms the repetitive stimulus and target sentences are the deviants requiring detection. In MS, P300 waveform latencies are significantly increased (>2 S.D) (Ivica et al, 2013;Magnano et al, 2006), indicating poorer cognitive performance (Sur and Sinha, 2009). In fact, cognitive impairment is now considered a primary deficit affecting 40-70% of pwMS, manifesting at all disease stages, even onset, and in all subtypes (Chiaravalloti and DeLuca, 2008).…”

Contingent Negative Variation Is Associated with Cognitive Dysfunction and Secondary Progressive Disease Course in Multiple Sclerosis

“…There has been growing interest in radiological and neurophysiological correlates of cognitive dysfunction in MS. Reports on other ERPs such as P300 or mismatch negativity in MS patients can be found in the literature, 25 , 26 , 27 but there has been a paucity of research on CNV in this patient group. 28 To the best of our knowledge, this is the first study to examine the association between CNV and neuropsychological functioning in MS patients, and the first to examine CNV differences between RRMS and SPMS patients.…”

Magnetoencephalography and High-Density Electroencephalography Study of Acoustic Event Related Potentials in Early Stage of Multiple Sclerosis: A Pilot Study on Cognitive Impairment and Fatigue

“…Due to the ease of recording and reliability, the P300 has become the most studied endogenous ERPs component. Results of many ERPs studies are consistent with prolonged P300 latencies [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] and/or smaller P300 amplitudes [ 30 , 33 , 36 ] in 50–65% of pwMS [ 38 ]. Significant correlations are reported between prolonged P300 latency and poorer scores on neuropsychological tests, as BRB, Mini Mental State Examination (MMSE), Wechsler adult intelligence scale (WAIS), and others [ 30 , 32 , 34 , 37 ], Expanded Disability Status Scale (EDSS) scores [ 31 , 35 , 36 , 37 ], disease duration [ 31 ] and Magnetic Resonance Imaging (MRI) lesion load [ 32 , 37 ].…”

“…Previous data from literature [ 30 , 33 , 36 ] have shown the prolonged latency of P300 in pwMS and its correlation with CI; only in one work, however [ 27 ], patients at the early stages of the disease, such as those diagnosed with CIS with the older McDonald’s criteria [ 57 ] were considered, among others, confirming P300 latency prolongation in the whole MS group. In our work, instead, the latency of P300 was prolonged but remained within normal limits.…”

Speech discrimination impairments as a marker of disease severity in multiple sclerosis

“…Parallels can be drawn to our SiN tasks: background noise forms the repetitive stimulus and target sentences are the deviants requiring detection. In MS, P300 waveform latencies are significantly increased (>2 S.D) (Ivica et al, 2013;Magnano et al, 2006), indicating poorer cognitive performance (Sur and Sinha, 2009). In fact, cognitive impairment is now considered a primary deficit affecting 40-70% of pwMS, manifesting at all disease stages, even onset, and in all subtypes (Chiaravalloti and DeLuca, 2008).…”

Contingent Negative Variation Is Associated with Cognitive Dysfunction and Secondary Progressive Disease Course in Multiple Sclerosis

“…There has been growing interest in radiological and neurophysiological correlates of cognitive dysfunction in MS. Reports on other ERPs such as P300 or mismatch negativity in MS patients can be found in the literature, 25 , 26 , 27 but there has been a paucity of research on CNV in this patient group. 28 To the best of our knowledge, this is the first study to examine the association between CNV and neuropsychological functioning in MS patients, and the first to examine CNV differences between RRMS and SPMS patients.…”

Magnetoencephalography and High-Density Electroencephalography Study of Acoustic Event Related Potentials in Early Stage of Multiple Sclerosis: A Pilot Study on Cognitive Impairment and Fatigue

“…Due to the ease of recording and reliability, the P300 has become the most studied endogenous ERPs component. Results of many ERPs studies are consistent with prolonged P300 latencies [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] and/or smaller P300 amplitudes [ 30 , 33 , 36 ] in 50–65% of pwMS [ 38 ]. Significant correlations are reported between prolonged P300 latency and poorer scores on neuropsychological tests, as BRB, Mini Mental State Examination (MMSE), Wechsler adult intelligence scale (WAIS), and others [ 30 , 32 , 34 , 37 ], Expanded Disability Status Scale (EDSS) scores [ 31 , 35 , 36 , 37 ], disease duration [ 31 ] and Magnetic Resonance Imaging (MRI) lesion load [ 32 , 37 ].…”

“…Previous data from literature [ 30 , 33 , 36 ] have shown the prolonged latency of P300 in pwMS and its correlation with CI; only in one work, however [ 27 ], patients at the early stages of the disease, such as those diagnosed with CIS with the older McDonald’s criteria [ 57 ] were considered, among others, confirming P300 latency prolongation in the whole MS group. In our work, instead, the latency of P300 was prolonged but remained within normal limits.…”

Speech discrimination impairments as a marker of disease severity in multiple sclerosis

“…Parallels can be drawn to our SiN tasks: background noise forms the repetitive stimulus and target sentences are the deviants requiring detection. In MS, P300 waveform latencies are significantly increased (>2 S.D) (Ivica et al, 2013;Magnano et al, 2006), indicating poorer cognitive performance (Sur and Sinha, 2009). In fact, cognitive impairment is now considered a primary deficit affecting 40-70% of pwMS, manifesting at all disease stages, even onset, and in all subtypes (Chiaravalloti and DeLuca, 2008).…”

Contingent Negative Variation Is Associated with Cognitive Dysfunction and Secondary Progressive Disease Course in Multiple Sclerosis

“…There has been growing interest in radiological and neurophysiological correlates of cognitive dysfunction in MS. Reports on other ERPs such as P300 or mismatch negativity in MS patients can be found in the literature, 25 , 26 , 27 but there has been a paucity of research on CNV in this patient group. 28 To the best of our knowledge, this is the first study to examine the association between CNV and neuropsychological functioning in MS patients, and the first to examine CNV differences between RRMS and SPMS patients.…”