P300 Wave Changes in Patients with Multiple Sclerosis

Abstract

Introduction:In patients with multiple sclerosis among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes.Goal:The aim of this study was to demonstrate that patients with multiple sclerosis have reduced amplitude and prolonged latency, longer than 300 ± 10 ms.Methods:The study included group of patients with multiple sclerosis and control group. After reviewing the medical records both groups of 14 participants were subjected to the same testing procedures auditory cognitive potentials (P300).Results:We have shown that patients with multiple sclerosis don’t have prolonged P300 target stimulus latency, but they have a longer P300 frequent stimulus latency for 18 ms. From 14 patients seven had a pathological P300 target stimulus amplitude, and even 12 patient had pathological P300 frequent stimulus amplitude.Conclusion:People with multiple sclerosis have altered P300 which indicates the presence of cognitive dysfunction in these patients.

Effects of differences in serum total homocysteine, folate, and vitamin B12on cognitive impairment in stroke patients

“…The P300 event-related potential is an objective electrophysiologic examination that reflects brain cognition function [ 25 , 26 ]. Related research has shown that patients with mild cognitive impairment exhibit changes in P300 [ 27 ].…”

Contingent Negative Variation Is Associated with Cognitive Dysfunction and Secondary Progressive Disease Course in Multiple Sclerosis

“…There has been growing interest in radiological and neurophysiological correlates of cognitive dysfunction in MS. Reports on other ERPs such as P300 or mismatch negativity in MS patients can be found in the literature, 25 , 26 , 27 but there has been a paucity of research on CNV in this patient group. 28 To the best of our knowledge, this is the first study to examine the association between CNV and neuropsychological functioning in MS patients, and the first to examine CNV differences between RRMS and SPMS patients.…”

Multimodal evoked potentials and transcranial magnetic stimulation in diagnostics of children with encephalitis, acute disseminated encephalomyelitis and multiple sclerosis

“…Латентный период Р300 был достоверно увеличен только в группе детей с РС и в среднем на 22 мс превышал норму (p <0,01). Замедление скорости когнитивных процессов у больных РС в виде увеличения латентного периода Р300 в нашем исследовании подтверждается данными других исследований с использованием КВП на слуховой стимул, что объясняется процессом демиелинизации [20]. B. S. Giesser и соавт.…”