P300 latency reflects the degree of cognitive decline in dementing illness

Polich, John; Ehlers, Cindy L.; Otis, Shirley M.; Mandell, Arnold J.; Bloom, Floyd E.

doi:10.1016/0013-4694(86)90007-6

Cited by 323 publications

(112 citation statements)

References 16 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…P300 latency decreases as children develop (Howard and Polich, 1985;Polich et al, 1990a) and increases with normal aging (Fjell and Walhovd, 2001;Polich, 1996). Component latency also becomes longer as dementia level increases (O'Donnell et al, 1992;Polich and Corey-Bloom, 2005;Polich et al, 1986Polich et al, , 1990bPotter and Barrett, 1999), although few reports suggest how brain insult or disease prolong ERP timing (Bashore and Ridderinkhof, 2002;Polich, 2004).…”

Section: P300 Latencymentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

Self Cite

6,329

458

6,265

View full text Add to dashboard Cite

The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/ standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulusdriven frontal attention mechanisms during task processing, whereas P3b originates from temporalparietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

show abstract

Section: P300 Latencymentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

Self Cite

6,329

458

6,265

View full text Add to dashboard Cite

show abstract

“…Subsequent clinical studies confirmed that the amplitude of P300 is reduced, and its latency increased, in the presence of cognitive impairment (e.g., Polich et al, 1986;O'Donnell et al, 1992;Potter and Barrett, 1999). P300 may serve overlapping functions in research on cognitive dysfunction: One is as a clinical assay of a disease-associated marker.…”

Section: Clinical Applicationsmentioning

confidence: 94%

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan

Barry

Connolly

et al. 2009

Clinical Neurophysiology

Self Cite

995

845

View full text Add to dashboard Cite

“…The P300 was executed following the individual's circadian cycle in the morning, when the awareness and concentration status are ideal and favor the P300 generation 16,17 . The response required from the target stimulus was motor, in order to maintain the state of awareness -factors which favor the P300 acquisition 12,18 . In the present study, the CG, made up of primary snorers, had a prevalence of 58.33% of individuals with more than 40 years, and in a 1:1 ratio, as far as gender is concerned.…”

Section: Discussionmentioning

confidence: 99%

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300

Martins

Júnior²,

Filho

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

View full text Add to dashboard Cite

The obstructive sleep apnea syndrome (OSAS) reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction. Objective:To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients. Materials and Methods:Prospective study with primary snorers (N=12) and in OSAS patients (N=54), submitted to polysomnography, defined by the apnea-hypopnea index (AHI). The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance level of 5%.Results: AIH had an inverse correlation with the oximetry in both groups. The P300 prevalence was lower in the OSAS group (Fisher's Exact Test, p=0.027). Patient age did not influence the P300 prevalence (regression analysis; p=0.232). The P300 amplitude was lower in the OSAS group (t-Student test; p=0.003) and the P300 latency was similar in both groups (t-Student test; p=0.89). Conclusion:The reduction in the P300 amplitude in patients with OSAS suggests cognitive dysfunction induced by a reduction in auditory memory. Braz J Otorhinolaryngol. 2011;77(6):700-5. ORIGINAL ARTICLE BJORL

show abstract

P300 latency reflects the degree of cognitive decline in dementing illness

Cited by 323 publications

References 16 publications

Updating P300: An integrative theory of P3a and P3b

Updating P300: An integrative theory of P3a and P3b

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300

Contact Info

Product

Resources

About