P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats

Li, Lin; Yang, Jingjian; Liu, Baoe; Zou, Yuting; Sun, Minghao; Li, Zijing; Yang, Runan; Xu, Xiaoxiao; Zou, Lifang; Li, Guilin; Liu, Shuangmei; Liang, Shangdong

doi:10.1016/j.biopha.2020.110803

Cited by 6 publications

(14 citation statements)

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“…Hepatic GK enzyme activity of glycolysis pathway is stimulated by glucose uptake [ 57 ], contributing an increase in liver glycogen content to maintain glucose homeostasis. In contrast, the downregulation of hepatic GK gene and protein expression was accompanied by reduced hepatic glycogen synthesis in type 2 diabetic rats [ 58 ]. The findings of the present study showed that dietary taurine supplementation could inhibit the glycolysis pathway as well as the biosynthesis of pyruvate, which is the final metabolites of glycolysis and the substrate for lipid synthesis de novo.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Transcriptome Analysis Provides New Insight into the Lipid-Reducing Effect of Dietary Taurine in High–Fat Fed Groupers (Epinephelus coioides)

et al. 2022

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A transcriptome analysis was conducted to provide the first detailed overview of dietary taurine intervention on liver lipid accumulation caused by high–fat in groupers. After an eight-week feeding, the fish fed 15% fat diet (High–fat diet) had higher liver lipid contents vs. fish fed 10% fat diet (Control diet). 15% fat diet with 1% taurine (Taurine diet) improved weight gain and feed utilization, and decreased hepatosomatic index and liver lipid contents vs. the High–fat diet. In the comparison of the Control vs. High–fat groups, a total of 160 differentially expressed genes (DEGs) were identified, of which up- and down-regulated genes were 72 and 88, respectively. There were 49 identified DEGs with 26 and 23 of up- and down-regulated in the comparison to High–fat vs. Taurine. Several key genes, such as cysteine dioxygenase (CDO1), ADP–ribosylation factor 1/2 (ARF1_2), sodium/potassium–transporting ATPase subunit alpha (ATP1A), carnitine/acylcarnitine translocase (CACT), and calcium/calmodulin–dependent protein kinase II (CAMK) were obtained by enrichment for the above DEGs. These genes were enriched in taurine and hypotaurine metabolism, bile secretion, insulin secretion, phospholipase D signaling pathway, and thermogenesis pathways, respectively. The present study will also provide a new insight into the nutritional physiological function of taurine in farmed fish.

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Section: Discussionmentioning

confidence: 99%

Hepatic Transcriptome Analysis Provides New Insight into the Lipid-Reducing Effect of Dietary Taurine in High–Fat Fed Groupers (Epinephelus coioides)

et al. 2022

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“…Insulin resistance induced by hypoxia can be relieved by sympathetic nervous system inhibition. Catecholamines mitigate insulin secretion [ 16 , 17 ].…”

Section: Challenges Associated With T2dm Studiesmentioning

confidence: 99%

“…The receptor might be involved in liver fibrosis, autoimmune pathologies, and platelet aggregation. There is not much information known about the P2Y12 receptor function in nutrient metabolism [ 16 , 23 – 25 ]. Table 1 shows P2Y receptor subtypes' distribution, G-proteins, and agonists.…”

Section: Challenges Associated With T2dm Studiesmentioning

confidence: 99%

“…The function and expression of P2 receptors have been studied in the liver. Nonetheless, it is still ambiguous whether changes in P2Y12 receptor expression have an effect on the CG or liver [ 16 ]. Figure 1 shows the purinergic receptors' role in governing the secretion of insulin and the survival of β -cells.…”

Section: Challenges Associated With T2dm Studiesmentioning

confidence: 99%

“…The above phenomenon is accompanied by the release of proinflammatory factors like interleukin 1- β (IL-1 β ). Such proinflammatory factors are known for exaggerating inflammatory response and cell dysfunction [ 16 ].…”

Section: Challenges Associated With T2dm Studiesmentioning

confidence: 99%

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Type 2 Diabetes Mellitus (T2DM) and Carbohydrate Metabolism in Relation to T2DM from Endocrinology, Neurophysiology, Molecular Biology, and Biochemistry Perspectives

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Tang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Type 2 diabetes mellitus (T2DM) is a severe disease caused by metabolic disorders, particularly carbohydrate metabolism disorders. The disease is a fatal global trouble characterised by high prevalence rates, causing death, blindness, kidney failure, myocardial infarction, amputation of lower limps, and stroke. Biochemical metabolic pathways like glycolysis, gluconeogenesis, glycogenesis, and glycogenolysis are critical pathways that regulate blood glucose levels with the glucokinase (GK) enzyme playing a central role in glucose homeostasis. Any factor that perturbs the aforementioned biochemical pathways is detrimental. Endocrinological, neurophysiological, and molecular biological pathways that are linked to carbohydrate metabolism should be studied, grasped, and manipulated in order to alleviate T2DM global chaos. The challenge, howbeit, is that, since the body is an integration of systems that complement one another, studying one “isolated” system is not very useful. This paper serves to discuss endocrinology, neurophysiology, and molecular biology pathways that are involved in carbohydrate metabolism in relation to T2DM.

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The potential role of CpG oligodeoxynucleotides on diabetic cardiac autonomic neuropathy mediated by P2Y12 receptor in rat stellate ganglia

Lin

Liu

et al. 2023

International Immunopharmacology

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P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats

Cited by 6 publications

References 55 publications

Hepatic Transcriptome Analysis Provides New Insight into the Lipid-Reducing Effect of Dietary Taurine in High–Fat Fed Groupers (Epinephelus coioides)

Hepatic Transcriptome Analysis Provides New Insight into the Lipid-Reducing Effect of Dietary Taurine in High–Fat Fed Groupers (Epinephelus coioides)

Type 2 Diabetes Mellitus (T2DM) and Carbohydrate Metabolism in Relation to T2DM from Endocrinology, Neurophysiology, Molecular Biology, and Biochemistry Perspectives

The potential role of CpG oligodeoxynucleotides on diabetic cardiac autonomic neuropathy mediated by P2Y12 receptor in rat stellate ganglia

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