P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration

Drysdale, Candace; Park, Keunha; Vessey, Kirstan A.; Huang, Xianming; Caruso, Emily; Li, Yihan; Wong, Joelyn; Wiley, James S.; Fletcher, Erica L.; Guymer, Robyn H.; Gu, Ben

doi:10.1007/s11302-022-09894-y

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Furthermore, CD163+ monocytes and macrophages may have a role in AMD pathology and progression (Swayze et al, 2022). In late stages of AMD, these changes in monocyte function can potentially be modified by the P2X7 receptor, which is expressed in a variety of cells, especially in monocytes, and can function as a scavenger receptor mediating phagocytosis (Drysdale et al, 2022). The P2X7 receptor mediated membrane fluidity, which was reduced across several types of leukocytes, including monocytes, in advanced AMD.…”

Section: Monocytesmentioning

confidence: 99%

“…Neutrophils are a type of leukocyte that drive both acute and chronic inflammation (Kolaczkowska and Kubes, 2013). As with monocytes, the P2X7 receptor mediates membrane fluidity, which is reduced in neutrophils and other leukocytes in advanced AMD (Drysdale et al, 2022). Furthermore, the neutrophil-to-leukocyte ratio is higher in patients with neovascular AMD (Niazi et al, 2019).…”

Section: Neutrophilsmentioning

confidence: 99%

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Innate immune biology in age-related macular degeneration

Ascunce

Dhodapkar²,

Huang³

et al. 2023

Front. Cell Dev. Biol.

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Age-related macular degeneration (AMD) is a neurodegenerative disease and a leading cause of irreversible vision loss in the developed world. While not classically described as an inflammatory disease, a growing body of evidence has implicated several components of the innate immune system in the pathophysiology of age-related macular degeneration. In particular, complement activation, microglial involvement, and blood-retinal-barrier disruption have been shown to play key roles in disease progression, and subsequent vision loss. This review discusses the role of the innate immune system in age-related macular degeneration as well as recent developments in single-cell transcriptomics that help advance the understanding and treatment of age-related macular degeneration. We also explore the several potential therapeutic targets for age-related macular degeneration in the context of innate immune activation.

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Section: Monocytesmentioning

confidence: 99%