Prevalence of Age-Related Macular Degeneration in Patients with Chronic Exposure to P2X7R Inhibitors

Woo, Kwang Min; Mahrous, M. Abdallah; D’Amico, Donald J.; Kiss, Szilard; Kovacs, Kyle D.

doi:10.1007/s00417-024-06507-9

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Ferroptosis and Ophthalmic Disorders1

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2024

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“…Age-related macular degeneration (AMD) is a complex ocular disorder that occurs with ageing and is characterized by a deterioration in the macula structure and function ( 251 ). The macula, which is situated at the retina’s core, is pivotal for sharp central vision ( 252 ).…”

Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%