P2X7 inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury

Tu, Guihua; Li, Guilin; Peng, Haiying; Hu, Jiang; Li, Jun; Kong, Fang; Liu, Shuangmei; Gao, Yun; Xu, Changshui; Xu, Xiaoling; Qiu, Shuyi; Fan, Bo; Zhu, Qicheng; Yu, Shicheng; Zheng, Chaoran; Wu, Bing; Peng, Li; Song, Miaomiao; Wu, Qin; Liang, Shangdong

doi:10.1016/j.brainresbull.2013.05.004

Cited by 42 publications

(50 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sensory-sympathetic coupling in SCG after myocardial ischaemic injury facilitates sympathoexcitatory action via upregulated P2X7R [590]. The P2X7R antagonist brilliant blue G acting on stellate ganglia prevented the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischaemic injury [591]. It has been claimed that ATP post-conditioning provides a powerful protective effect in a rat model of ischaemia-reperfusion due partly to antioxidation and partly to inhibition of inflammation [592].…”

Section: Ischaemiamentioning

confidence: 99%

Cardiac purinergic signalling in health and disease

Burnstock

Pelleg

2014

Purinergic Signalling

113

View full text Add to dashboard Cite

This review is a historical account about purinergic signalling in the heart, for readers to see how ideas and understanding have changed as new experimental results were published. Initially, the focus is on the nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory nerves, as well as in intracardiac neurons. Control of the heart by centers in the brain and vagal cardiovascular reflexes involving purines are also discussed. The actions of adenine nucleotides and nucleosides on cardiomyocytes, atrioventricular and sinoatrial nodes, cardiac fibroblasts, and coronary blood vessels are described. Cardiac release and degradation of ATP are also described. Finally, the involvement of purinergic signalling and its therapeutic potential in cardiac pathophysiology is reviewed, including acute and chronic heart failure, ischemia, infarction, arrhythmias, cardiomyopathy, syncope, hypertrophy, coronary artery disease, angina, diabetic cardiomyopathy, as well as heart transplantation and coronary bypass grafts.

show abstract

Section: Ischaemiamentioning

confidence: 99%

Cardiac purinergic signalling in health and disease

Burnstock

Pelleg

2014

Purinergic Signalling

113

View full text Add to dashboard Cite

show abstract

“…Evidence has indicated that the P2X7 receptor was involved in the process of inflammatory response and release of inflammatory mediators [20,21]. Our previous studies also showed that the P2X7 receptor played a major role in the transmission of inflammatory signals and contributed to the pathological process of sympathetic injury [6,10,[22][23][24][25].…”

Section: Introductionmentioning

confidence: 78%

“…The nucleotide receptor P2X7 is recently regarded as a potential therapeutic target for inflammatory relevant diseases such as diabetes [17,21,22]. As a ligand-gated cation channel, the P2X7 receptor can be activated by extracellular ATP.…”

Section: Discussionmentioning

confidence: 99%

“…As a ligand-gated cation channel, the P2X7 receptor can be activated by extracellular ATP. Overstimulation of the P2X7 receptor by massive amounts of extracellular ATP may induce uncontrolled Ca 2+ influx, and activate the release of mature cytokines like IL-6 and TNF-α, which in turn could induce neurotoxicity and cell death [21,22]. Therefore, target on the P2X7 receptor raised the possibility of inhibiting inflammation and thus may be one of the potential therapeutic strategies for DNP.…”

Section: Discussionmentioning

confidence: 99%

“…This finding suggests nc021972 may be involved in the pathophysiologic processes related to the sympathetic neuron under the setting of diabetes. Our previous studies have shown that the P2X7 receptor was implicated in the pathological injury of sympathetic nerves [6,10,[22][23][24][25]. The aim of the study was to examine the effects of nc021972 small interference RNA (siRNA) on the P2X7 receptor and its possible role in neuroinflammation induced by elevated glucose and FFAs in PC12 cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

LncRNA NONRATT021972 siRNA attenuates P2X7 receptor expression and inflammatory cytokine production induced by combined high glucose and free fatty acids in PC12 cells

Liu

et al. 2016

Purinergic Signalling

Self Cite

View full text Add to dashboard Cite

Diabetic neuropathy (DNP) is a frequent chronic complication of diabetes mellitus with potentially lifethreatening outcomes. High glucose and elevated free fatty acids (FFAs) have been recently recognized as major causes of nervous system damage in diabetes. Our previous study has indicated extracellular stimuli, such as high glucose and/or FFA stress, may activate the p38 mitogen-activated protein kinase (MAPK) signaling pathway and induce a p38 MAPK-dependent sensitization of the P2X7 receptor and release of inflammatory factors in PC12 cells, while the mechanisms underlying remain to be elucidated. Long noncoding RNAs (lncRNAs) play important roles in diverse biological processes, including activation of a series of pathway signalings. Here, we showed combined high D-glucose and FFAs ( H G H F ) i n d u c e d a n i n c r e m e n t o f l n c R N A -NONRATT021972 (NONCODE ID, nc021972) in PC12 cells. Nc021972 small interference RNA (siRNA) alleviated HGHF-induced activation of p38 MAPK, expression of the P2X7 receptor, and [Ca 2+ ] i increment upon P2X7 receptor activation. Further experiments showed that there existed a crosstalk between nc021972 and the p38 MAPK signaling pathway. Inhibition of p38 MAPK signaling decreased nc021972-induced expression of the P2X7 receptor and [Ca 2+ ] i increment upon P2X7 receptor activation. Also, nc021972 siRNA inhibited HGHF-induced PC12 release of TNF-α and IL-6 and rescued decreased cell viability mediated by the P2X7 receptor. Therefore, inhibition of nc021972 may serve as a novel therapeutic strategy for diabetes complicated with nervous inflammatory diseases.

show abstract

P2X receptors mediated abnormal interaction between satellite glial cells and neurons in visceral pathological changes

Wang

Yang

et al. 2019

Cell Biology International

Self Cite

View full text Add to dashboard Cite

The adenosine triphosphate (ATP)-gated P2X receptor cation channel family consists of permeable ligand-gated ion channels that expand on the binding of extracellular adenosine 5'-ATP. ATP-gated P2X receptors are trimer ion channels that assemble homo or isomer from seven cloned subunits. P2X receptors are discovered mostly in mammalian and are being found in an increasing number of non-vertebrates, such as zebrafish, bullfrog, and ameba. P2X receptors are involved in many physiological processes, including regulation of heart rhythm and contractility, and regulation of pain, especially chronic pain and glia integration. This review summarizes the current studies on the regulation of P2X receptors in abnormal neuronal-glial interaction and the pathological changes in viscera, especially in myocardial ischemia.

show abstract

P2X7 inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury

Cited by 42 publications

References 64 publications

Cardiac purinergic signalling in health and disease

Cardiac purinergic signalling in health and disease

LncRNA NONRATT021972 siRNA attenuates P2X7 receptor expression and inflammatory cytokine production induced by combined high glucose and free fatty acids in PC12 cells

P2X receptors mediated abnormal interaction between satellite glial cells and neurons in visceral pathological changes

Contact Info

Product

Resources

About