P2X receptors mediated abnormal interaction between satellite glial cells and neurons in visceral pathological changes

Wang, Zilin; Li, Lin; Yang, Runan; Xu, Xiaoxiao; Liang, Shangdong

doi:10.1002/cbin.11195

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Conversely, satellite glia encircle peripheral neuronal cell bodies, and have been likened to central nervous system (CNS) astrocytes (Kastriti and Adameyko, 2017). There is also growing support for a role for satellite glia in regulating pain (Jasmin et al, 2010;Ji et al, 2013;Song et al, 2018;Wang et al, 2019;Zhang et al, 2020). Despite their distinct positioning, Schwann cells (wrapping axons) and satellite glia (wrapping neuronal cell bodies)…”

Section: Introductionmentioning

confidence: 99%

Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

Balakrishnan

Belfiore

Vasan

et al. 2020

Preprint

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Schwann cells are the principal glial cells of the peripheral nervous system, and their development into myelinating glia is critically dependent on MEK/ERK signaling. Ets-domain transcription factors (Etv1, Etv4, Etv5) are common downstream effectors of MEK/ERK signalling, but so far, only Etv1 has been ascribed a role in Schwann cell development, and only in non-myelinating cells. Here, we examined the role of Etv5, which is expressed in Schwann cell precursors, including neural crest cells and satellite glia, in Schwann cell lineage development. We analysed Etv5tm1Kmm mutants (designated Etv5−/−) at embryonic days (E) 12.5, E15.5 and E18.5, focusing on dorsal root ganglia. At these embryonic stages, satellite glia (glutamine synthetase) and Schwann cell markers, including transcriptional regulators (Sox10, Sox9, Tfap2a, Pou3f1) and non-transcription factors (Ngfr, BFABP, GFAP), were expressed in the DRG of wild-type and Etv5−/− embryos. Furthermore, by E18.5, quantification of Sox10+ Schwann cells and NeuN+ neurons revealed that these cells were present in normal numbers in the Etv5−/− dorsal root ganglia. We next performed peripheral nerve injuries at postnatal day 21, revealing that Etv5−/− mice had an enhanced injury response, generating more Sox10+ Schwann cells compared to wild-type animals at five days post-injury. Thus, while Etv5 is not required for Schwann cell development, possibly due to genetic redundancy with Etv1 and/or Etv4, Etv5 is an essential negative regulator of the peripheral nerve injury repair response.SIGNIFICANCE STATEMENTOur study sought to determine whether the ets domain transcription factor, Etv5, plays a role in regulating Schwann cell development and nerve repair. By using an embryonically and postnatally viable hypomorphic Etv5 mutant allele, we demonstrated that Etv5 is not required for the development of Schwann cells or other neural crest derivatives in the dorsal root ganglia, including satellite glia and neurons. Surprisingly, loss of Etv5 had a direct impact on the Schwann cell repair response post-injury, resulting in more Schwann cells populating the distal injured nerve site compared to wild-type animals. Thus, this work describes for the first time a role for Etv5 in regulating the Schwann cell repair response after peripheral nerve injury.

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Section: Introductionmentioning

confidence: 99%

Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

Balakrishnan

Belfiore

Vasan

et al. 2020

Preprint

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Neural control of gut homeostasis

Abdullah

Defaye

Altier

2020

American Journal of Physiology-Gastrointestinal and Liver Physi

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The gut-brain axis is a coordinated communication system that not only maintains homeostasis, but significantly influences higher cognitive functions and emotions as well as neurological and behavioral disorders. Among the large populations of sensory and motor neurons that innervate the gut, insights into the function of primary afferent nociceptors whose cell bodies reside in the dorsal root ganglia and nodose ganglia, have revealed their multiple crosstalk with several cell types within the gut wall, including epithelial, vascular and immune cells. These bi-directional communications have immunoregulatory functions, control host response to pathogen, and modulate sensation associated with gastrointestinal disorders, through activation of immune cells and glia in the peripheral and central nervous system, respectively. Here we will review the cellular and neurochemical basis of these interactions at the periphery, in dorsal root ganglia and in the spinal cord. We will discuss the research gaps that should be addressed to get a better understanding of the multifunctional role of sensory neurons in maintaining gut homeostasis and regulating visceral sensitivity.

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P2X receptors mediated abnormal interaction between satellite glial cells and neurons in visceral pathological changes

Cited by 2 publications

References 44 publications

Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

Neural control of gut homeostasis

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