P2X1 receptor-mediated pressor responses in the anesthetized mouse

Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses

“…Our work supports an important role of P2X1 in mediating sympathetic neurogenic contraction of small arteries [29,48]. P2X1 is also involved in pressure-induced autoregulatory vasoconstriction in renal afferent arterioles [24,25], and intravenous infusion of the P2X1 agonist -meATP causes a strong pressor effect in vivo [30]. P2X receptor subtypes display varying degrees of desensitisation, and P2X1 undergoes rapid desensitisation in the presence of agonist [41].…”

Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits

“…It is now established that P2X receptors, ligand-gated Ca 2+ -permeable cation channels expressed in the plasma membrane of vascular smooth muscle cells (VSMC), are responsible for vasoconstrictor responses induced by neuronal released ATP. In muscular arteries, it is proposed that activation of P2X receptors leads to membrane depolarisation, followed by an increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ) and vasoconstriction, which evokes a rise in blood pressure [17,24]. Therefore P2X receptors may represent an important therapeutic target for treatment of hypertension.…”