P29 MMP-8 and MMP-9 serum levels as possible early markers for remission after traumatic spinal cord injury

Heller, Raban Arved; Daniel, V.; Swing, Tyler; Akbar, Muhammad Rizki; Gerner, Hans Jürgen; Biglari, Bahram; Moghaddam-Alvandi, A.

doi:10.1016/s0020-1383(16)30580-0

Cited by 3 publications

(3 citation statements)

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“…Participants were not given methylprednisolone sodium succinate during study participation. During a total of 3 months, 11 blood samples were taken at specific time points after fixed protocol analog to our previous studies (Figure 2) [3,26,27,28,29,30,31,32,33,34].…”

Section: Patients Material and Methodsmentioning

confidence: 99%

The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study

et al. 2019

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In the secondary injury phase after traumatic spinal cord injury (TSCI), oxidative stress and neuroinflammatory responses at the site of injury constitute crucial factors controlling damage extent and may serve as potential therapeutic targets. We determined Magnesium (Mg) serum concentration dynamics in context with the potential of neurological remission in patients with TSCI as Mg is suspected to limit the production of reactive oxygen species and reduce lipid peroxidation. A total of 29 patients with acute TSCI were enrolled, and blood samples were drawn over 3 months at 11 time-points and Mg quantification was performed. Patients were divided into those with (G1, n = 18) or without neurological remission (G0, n = 11). Results show a slight drop in Mg level during the first 4 h after injury, then remained almost unchanged in G1, but increased continuously during the first 7 days after injury in G0. At day 7 Mg concentrations in G1 and G0 were significantly different (p = 0.039, G0 > G1). Significant differences were detected between patients in G1 that presented an AIS (ASIA Impairment Scale) conversion of 1 level versus those with more than 1 level (p = 0.014, G1 AIS imp. = +1 > G1 AI imp. > +1). Low and decreasing levels of Mg within the first 7 days are indicative of a high probability of neurological remission, whereas increasing levels are associated with poor neurological outcome.

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Section: Patients Material and Methodsmentioning

confidence: 99%

The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study

et al. 2019

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“…Analog to the duration of the study (72 h) in the protocol of Kijima et al [23], from admission to the end of follow up, 6 blood samples were taken at specific points in time over 72 h according to our protocol (Figure 1). The protocol was adapted from our previous studies [25][26][27][28][29][30][31][32][33]. After blood sampling and 20 min of coagulation, the blood was centrifuged at 3000 rpm with an RCF (Relative Centrifugal Force) of 1008 m/s 2 , aliquoted, and stored at −80 • C until analysis.…”

Section: Source Of Datamentioning

confidence: 99%

“…The register has already been used to address related scientific issues before in the quest for suitable biomarkers for this devastating disease [8,[25][26][27][28][29][30][31][32][33][38][39][40][41]. The analyses were performed retrospectively, whereas the samples were collected prospectively in the biobank.…”

Section: Related Workmentioning

confidence: 99%

Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury

et al. 2020

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Traumatic Spinal Cord Injury (TSCI) is debilitating and often results in a loss of motor and sensory function caused by an interwoven set of pathological processes. Oxidative stress and inflammatory processes are amongst the critical factors in the secondary injury phase after TSCI. The essential trace element Zinc (Zn) plays a crucial role during this phase as part of the antioxidant defense system. The study aims to determine dynamic patterns in serum Zn concentration in patients with TSCI and test for a correlation with neurological impairment. A total of 42 patients with TSCI were enrolled in this clinical observational study. Serum samples were collected at five different points in time after injury (at admission, and after 4 h, 9 h, 12 h, 24 h, and 3 days). The analysis of the serum Zn concentrations was conducted by total reflection X-ray fluorescence (TXRF). The patients were divided into two groups—a study group S (n = 33) with neurological impairment, including patients with remission (G1, n = 18) and no remission (G0, n = 15) according to a positive AIS (American Spinal Injury Association (ASIA) Impairment Scale) conversion within 3 months after the trauma; and a control group C (n = 9), consisting of subjects with vertebral fractures without neurological impairment. The patient data and serum concentrations were examined and compared by non-parametric test methods to the neurological outcome. The median Zn concentrations in group S dropped within the first 9 h after injury (964 µg/L at admission versus 570 µg/L at 9 h, p < 0.001). This decline was stronger than in control subjects (median of 751 µg/L versus 729 µg/L, p = 0.023). A binary logistic regression analysis including the difference in serum Zn concentration from admission to 9 h after injury yielded an area under the curve (AUC) of 82.2% (CI: 64.0–100.0%) with respect to persistent neurological impairment. Early Zn concentration dynamics differed in relation to the outcome and may constitute a helpful diagnostic indicator for patients with spinal cord trauma. The fast changes in serum Zn concentrations allow an assessment of neurological impairment risk on the first day after trauma. This finding supports strategies for improving patient care by avoiding strong deficits via adjuvant nutritive measures, e.g., in unresponsive patients after trauma.

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Novel approach to an early assessment of a patient’s potential for neurological remission after acute spinal cord injury: Analysis of hemoglobin concentration dynamics

Biglari

Heller

Hörner

et al. 2019

The Journal of Spinal Cord Medicine

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P29 MMP-8 and MMP-9 serum levels as possible early markers for remission after traumatic spinal cord injury

Cited by 3 publications

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The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study

The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study

Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury

Novel approach to an early assessment of a patient’s potential for neurological remission after acute spinal cord injury: Analysis of hemoglobin concentration dynamics

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