Novel approach to an early assessment of a patient’s potential for neurological remission after acute spinal cord injury: Analysis of hemoglobin concentration dynamics

Biglari, Bahram; Heller, Raban Arved; Hörner, Manuel; Sperl, André; Bock, Tobias; Reible, Bruno; Haubruck, Patrick; Grützner, Paul Alfred; Moghaddam, Arash

doi:10.1080/10790268.2019.1632060

Cited by 5 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies on the relationship between Hb and neurological function have been reported in many literatures. For example, recent studies have shown that elevated Hb concentrations are associated with a higher likelihood of neurological remission, in other words, there is a link between the probability of neurological remission and the Hb concentration after TSCI [24] . Another study suggested that the changes in blood Hb concentration was signi cantly associated with the severity of SCI and was not accounted for by effects of age [25] .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and hematological profile of traumatic spinal cord injury: a retrospective study

Wei

Huo

et al. 2022

Preprint

View full text Add to dashboard Cite

Study design: A retrospective hospital-based study.Objective: To describe the epidemiological features and identify hematological indicators with prognostic value for function of traumatic spinal cord injury (TSCI) in Beijing, China.Setting: Xuanwu Hospital of Capital Medical University, Beijing.Methods: Routine blood and clinical data of TSCI patients who admitted to Xuanwu Hospital of Capital Medical University from 2015 to 2021 were collected for detailed investigation.Results: In all, 129 cases were identified. The most commonly affected age group was 46-60 years, and male-to-female ratio was 2.5:1. The leading cause was low fall (50.4%), followed by transport (25.6%). The most common injury site was the cervical spinal cord, especially C5, accounting for 86.0%. The proportion of TSCI patients receiving rehabilitation treatment after acute management was 27.2%. In addition, hemoglobin (Hb) concentrations in TSCI patients with increased Barthel index (BI) scores were significantly higher than those without increased BI scores (P＜0.05). Conclusion: Prevention strategies for TSCI should mainly target 46-60 age group, males and low fall. The results of this study will serve as a basis for further studies on TSCI, at least in Beijing. The preventive programs should be designed according to the injury characteristics. Additionally, higher Hb concentration in peripheral blood is closely related to the improvement of activities of daily living (ADL) in TSCI patients, but further detailed research is urgently needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiological and hematological profile of traumatic spinal cord injury: a retrospective study

Wei

Huo

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Cessation of medication that could induce hypotension, maintain supraphysiological mean arterial blood pressure, acute MRI/CT to detect screw malposition or epidural hematoma, acute decompression or removal of spinal instrumentation are often suggested in literature [7,17,20]. Hemoglobin levels also effect spinal cord perfusion and elevated hemoglobin levels by red-cell transfusions have been associated with improved neurological outcome after traumatic spinal cord injury [21]. Although not described in literature, redcell transfusion till at least physiological hemoglobin levels could be considered in the treatment of delayed SCI.…”

Section: Discussionmentioning

confidence: 99%

The risk of delayed spinal cord injury in pediatric spinal deformity surgery

et al. 2022

View full text Add to dashboard Cite

Delayed spinal cord injury (SCI) hours or days after surgery, with uneventful monitoring and initial normal postoperative neurological examination, is a rare complication. Based on anecdotal evidence, the risk of delayed spinal cord injury might be higher than previously assumed. Therefore the aim of this study was to determine the risk of delayed SCI after pediatric spinal deformity surgery between 2013-2019 in the Netherlands. The total number of pediatric spinal deformity surgeries performed for scoliosis or kyphosis between 2013-2019 was obtained from the Dutch National Registration of Hospital Care. All eleven Dutch hospitals that perform pediatric spinal deformity surgery were contacted for occurrence of delayed SCI. From the identified patients with delayed SCI, the following data were collected: patient characteristics, details about the SCI, the surgical procedure, management and degree of improvement. 2884 pediatric deformity surgeries were identified between 2013-2019. Seven patients (0.24%) with delayed SCI were reported: 3 idiopathic, 2 neuromuscular (including 1 kypho-scoliosis) and 2 syndromic scoliosis. The risk of delayed SCI after pediatric deformity surgery was 1:595 in idiopathic scoliosis, 1:214 in syndromic scoliosis, 1:201 in neuromuscular scoliosis. All seven patients had a documented normal neurological examination in the first postoperative period; neurological deficits were first diagnosed at a median 16h (range 2.5-40) after surgery. The risk of delayed SCI after pediatric deformity surgery is higher than previously reported, especially in patients with non-idiopathic scoliosis. Regular postoperative testing for late neurologic deficit should be performed for timely diagnosis and management of this devastating complication.

show abstract

“…Participants were not given methylprednisolone sodium succinate during study participation. During a total of 3 months, 11 blood samples were taken at specific time points after fixed protocol analog to our previous studies (Figure 2) [3,26,27,28,29,30,31,32,33,34].…”

Section: Patients Material and Methodsmentioning

confidence: 99%

The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study

et al. 2019

Self Cite

View full text Add to dashboard Cite

In the secondary injury phase after traumatic spinal cord injury (TSCI), oxidative stress and neuroinflammatory responses at the site of injury constitute crucial factors controlling damage extent and may serve as potential therapeutic targets. We determined Magnesium (Mg) serum concentration dynamics in context with the potential of neurological remission in patients with TSCI as Mg is suspected to limit the production of reactive oxygen species and reduce lipid peroxidation. A total of 29 patients with acute TSCI were enrolled, and blood samples were drawn over 3 months at 11 time-points and Mg quantification was performed. Patients were divided into those with (G1, n = 18) or without neurological remission (G0, n = 11). Results show a slight drop in Mg level during the first 4 h after injury, then remained almost unchanged in G1, but increased continuously during the first 7 days after injury in G0. At day 7 Mg concentrations in G1 and G0 were significantly different (p = 0.039, G0 > G1). Significant differences were detected between patients in G1 that presented an AIS (ASIA Impairment Scale) conversion of 1 level versus those with more than 1 level (p = 0.014, G1 AIS imp. = +1 > G1 AI imp. > +1). Low and decreasing levels of Mg within the first 7 days are indicative of a high probability of neurological remission, whereas increasing levels are associated with poor neurological outcome.

show abstract

Novel approach to an early assessment of a patient’s potential for neurological remission after acute spinal cord injury: Analysis of hemoglobin concentration dynamics

Cited by 5 publications

References 52 publications

Epidemiological and hematological profile of traumatic spinal cord injury: a retrospective study

Epidemiological and hematological profile of traumatic spinal cord injury: a retrospective study

The risk of delayed spinal cord injury in pediatric spinal deformity surgery

The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study

Contact Info

Product

Resources

About