P286 The occupations associated with copd risk in the large population-based uk biobank cohort study

Matteis, Sara De; Jarvis, Déborah; Hutchings, Sally; Darnton, Andy; Fishwick, David; Sadhra, Steven; Rushton, Lesley; Cullinan, Paul

doi:10.1136/oemed-2016-103951.601

Cited by 3 publications

(5 citation statements)

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“…However, when they restricted to never smokers, findings attenuated 27 . Our study also identified increased risks for both sexes in janitor and cleaning occupations, similarly, a European study identified elevated risks across various cleaning occupations 18 . Our study also identified an elevated risk among laundering and dry-cleaning male workers, with only a slight increase among female workers.…”

Section: Discussionsupporting

confidence: 81%

“…They reported the highest risks among roofers (122% increased risk) and cement masons/bricklayers (136% increased risk) 12 . Another study in the UK observed higher risks of COPD among roofers, floorers and labourers, but not for masons or bricklayers 18 . It is likely that these workers are exposed to respirable dust given the nature of their work.…”

Section: Discussionmentioning

confidence: 91%

“…Workplace secondhand smoke (SHS) exposure has also been shown to be higher in non-smoking construction workers 23 . Studies have shown that when adjusting for smoking history or restricting to never smokers, there was little or no impact on risk estimates 14 , 18 , 24 .…”

Section: Discussionmentioning

confidence: 99%

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Risk of chronic obstructive pulmonary disease in a large cohort of Ontario, Canada workers

Sritharan,

Arrandale,

Kirkham

et al. 2024

Sci Rep

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Although several occupational exposures have been linked to the risk of COPD; limited data exists on sex-specific differences. This study aimed to identify at-risk occupations and sex differences for COPD risk. Cases were identified in a large surveillance system established through the linkage of former compensation claimants’ data (non-COPD claims) to physician visits, ambulatory care data, and hospital inpatient data (1983–2020). Cox proportional hazard models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CI) for occupation groups (occupation at time of claim), stratified by sex. HRs were indirectly adjusted for cigarette smoking using another population dataset. A total of 29,445 male and 14,693 female incident cases of COPD were identified. Increased risks were observed in both sexes for construction (HRmale 1.15, 95% CI 1.12–1.19; HRfemale 1.54, 95% CI 1.29–1.83) transport/equipment operating (HRmale 1.32, 95% CI 1.28–1.37; HRfemale 1.53, 95% CI 1.40–1.68) farming (HRmale 1.23, 95% CI 1.15–1.32; HRfemale 1.19, 95% CI 1.04–1.37) and janitors/cleaners (HRmale 1.31, 95% CI 1.24–1.37; HRfemale 1.40, 95% CI 1.31–1.49). Increased risks were observed for females employed as chefs and cooks (HR 1.44, 95% CI 1.31–1.58), bartenders (HR 1.38, 95% CI 1.05–1.81), and those working in food/beverage preparation (HR 1.34, 95% CI 1.24–1.45) among other occupations. This study demonstrates elevated risk of COPD among both male and female workers potentially exposed to vapours, gases, dusts, and fumes, highlighting the need for occupational surveillance of COPD.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 91%

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Risk of chronic obstructive pulmonary disease in a large cohort of Ontario, Canada workers

Sritharan,

Arrandale,

Kirkham

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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“…Two blows were recorded for each participant and a third blow was administered if the differences between both forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) of the first two blows were more than 5%. Acceptability of spirometry data was assessed by quality appraisal of a sample of maneuvers, as previously described [11]. The highest values for both FVC and FEV1 from acceptable blows were used in analyses.…”

Section: Lung Function and Copdmentioning

confidence: 99%

“…Asthma status was based on a self-reported doctor diagnosis of asthma. Lastly, participants reporting current employment for one of 14 jobs associated with an increased risk (prevalence ratio ≥ 1.30) for COPD identified by De Matteis et al [11] (Table S2) were classified as having an "at-risk" occupation.…”

Section: Confounder and Effect Modifier Variablesmentioning

confidence: 99%

Air pollution, lung function and COPD: results from the population-based UK Biobank study

et al. 2019

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Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors.We used UK Biobank data on 303 887 individuals aged 40–69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 µm: PM2.5 and PM10, respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PMcoarse) and nitrogen dioxide (NO2) concentrations with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio and COPD (FEV1/FVC <lower limit of normal). Effect modification was investigated for sex, age, obesity, smoking status, household income, asthma status and occupations previously linked to COPD.Higher exposures to each pollutant were significantly associated with lower lung function. A 5 µg·m−3 increase in PM2.5 concentration was associated with lower FEV1 (−83.13 mL, 95% CI −92.50– −73.75 mL) and FVC (−62.62 mL, 95% CI −73.91– −51.32 mL). COPD prevalence was associated with higher concentrations of PM2.5 (OR 1.52, 95% CI 1.42–1.62, per 5 µg·m−3), PM10 (OR 1.08, 95% CI 1.00–1.16, per 5 µg·m−3) and NO2 (OR 1.12, 95% CI 1.10–1.14, per 10 µg·m−3), but not with PMcoarse. Stronger lung function associations were seen for males, individuals from lower income households, and “at-risk” occupations, and higher COPD associations were seen for obese, lower income, and non-asthmatic participants.Ambient air pollution was associated with lower lung function and increased COPD prevalence in this large study.

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Education can Reduce Health Disparities Related to Genetic Risk of Obesity: Evidence from a British Reform

Turley

2018

Preprint

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This paper investigates whether genetic makeup moderates the effects of education on health. Low statistical power and endogenous measures of environment have been obstacles to the credible estimation of such gene-by-environment interactions.We overcome these obstacles by combining a natural experiment that generated variation in secondary education with polygenic scores for a quarter million individuals. The additional schooling affected body size, lung function, and blood pressure in middle age. The improvements in body size and lung function were larger for individuals with high genetic predisposition to obesity. As a result, education reduced the gap in unhealthy body size between those with high and low genetic risk of obesity from 20 to 6 percentage points.Educational policies may increase or decrease health disparities depending on whether they reinforce or counteract gene-related health disparities (1). Both childhood circumstances, such as education, and genetic factors are independently associated with later life health (2,3,4). A growing literature suggests that health may also depend on the interaction between these two factors (5,6,7). Where strong gene-by-environment (GxE) interactions exist, modest effects of education on average may conceal larger effects for populations with particular genotypes and lead to underestimates of the benefits of schooling. We investigate this possibility by testing whether genetic makeup moderates the effect of an additional year of secondary education on middle age health.After the publication of high-impact GxE studies (8,9,10), controversies over the replicability of results tempered the enthusiasm for this research program. Low statistical power and endogenous measures of environment are believed to be main reasons for the limited replicability (11,12,13). Many GxE studies are low-powered because behavioral traits tend to be

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P286 The occupations associated with copd risk in the large population-based uk biobank cohort study

Cited by 3 publications

References 0 publications

Risk of chronic obstructive pulmonary disease in a large cohort of Ontario, Canada workers

Risk of chronic obstructive pulmonary disease in a large cohort of Ontario, Canada workers

Air pollution, lung function and COPD: results from the population-based UK Biobank study

Education can Reduce Health Disparities Related to Genetic Risk of Obesity: Evidence from a British Reform

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