p27kip1 Expression in Rectal Cancer Correlates with Disease-Free Survival

Günther, Klaus; Jung, Andreas; Völker, Uwe; Meyer, Martin; Brabletz, Thomas; Matzel, Klaus E.; Reymond, Marc A.; Kirchner, Thomas; Hohenberger, Werner

doi:10.1006/jsre.2000.5871

Cited by 20 publications

(5 citation statements)

References 19 publications

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“…It is interesting to note that p27 expression in our series was frequently cytoplasmic (with or without concomitant nuclear staining). Although recent studies showed that cytoplasmic dislocation of p27 has a prognostic role in several tumors (35,36), we and others (23, 24) failed to find a correlation between p27 cytoplasmic staining and clinical outcome in endometrial cancer. The mechanism responsible for this phenomenon and its biological significance in these tumor cells continues to remain poorly understood.…”

Section: Discussioncontrasting

confidence: 65%

Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 (Kip1) in estrogen-related endometrial adenocarcinomas

Torricelli

Sanseverino

2004

The Women's Oncology Review

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Purpose: p27 Kip1 is a member of the Cip1/Kip1 family of cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Low levels of p27 are associated with poor prognosis in a variety of gynecological tumors, including breast, ovarian, and cervical carcinomas. The role of p27 in endometrial cancer remains controversial.Experimental Design: In the present study, p27 protein expression was investigated by immunohistochemistry in a series of 217 endometrial adenocarcinomas and, where present, in synchronous normal endometrium, simple and complex hyperplasia (with or without atypia), and cystic atrophy. The relationship between p27 expression and clinical outcome was also evaluated.Results: Immunohistochemical analysis revealed a significant loss of p27 expression from normal (33%) through hyperplastic endometrium (50%) to endometrial adenocarcinomas (71%; P < 0.001). In addition to nuclear staining, cytoplasmic localization of p27 was noted in 193 (91%) of 217 specimens examined. When the clinical outcome of the patients was evaluated in relation to p27 status, we found no significant correlation between the presence of p27 staining and clinicopathological parameters or survival.Conclusions: These data indicate that p27 expression could progressively decrease from normal endometrium through hyperplastic endometrium to invasive endometrial carcinomas, suggesting that loss of this tumor suppressor may represent a novel and distinct molecular alteration involved in estrogen-related endometrial adenocarcinomas (type I). Despite the suggested role of the p27 protein in determining the prognosis of several human tumors, it was not found to be a predictor of clinical outcome in this large group of patients with endometrial cancer.

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Section: Discussioncontrasting

confidence: 65%

Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 (Kip1) in estrogen-related endometrial adenocarcinomas

Torricelli

Sanseverino

2004

The Women's Oncology Review

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“…A number of molecular markers have already been investigated. Rectal cancers expressing the cyclin‐dependent kinase inhibitor p27(kip1) have a significantly better prognosis than tumours that do not107, 108. Sucrose–isomaltase expression is a predictor of colorectal cancer recurrence109.…”

Section: Treatment Selection For Early Rectal Cancermentioning

confidence: 99%

Management of early rectal cancer

Tytherleigh

Warren

Mortensen

2008

British Journal of Surgery

141

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“…The data suggest that cytoplasmic localization of p27 kip1 immunoreactivity is of little significance in PMMs. However, Gunther et al showed such localization to be a common event in rectal carcinoma and proved it to be the best prognostic factor of disease free survival in such neoplasms 25. Moreover, in this study patients with intensive cytoplasmic p27 kip1 expression (+++) showed a significantly poorer outcome, irrespective of their nuclear staining.…”

Section: Discussionmentioning

confidence: 49%

p27kip1 immunoreactivity correlates with long-term survival in pleural malignant mesothelioma

Bongiovanni

Cassoni

Giuli

et al. 2001

Cancer

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BACKGROUND Pleural malignant mesothelioma (PMM) is a rare and highly aggressive tumor, whose development is strictly related to occupational exposure to asbestos. The prognosis of PMM is generally poor (median survival, 4–12 months), but a few have a relatively long survival. The objective of this study was to evaluate the use of the cell cycle–related proteins p27kip1 and MIB‐1 as prognostic indicators of survival in PMMs. METHODS Of 621 PMMs, the authors selected 27 cases with a relatively long‐term survival (> 24 months) and a control group of 36 PMMs having a shorter (usual) survival (< 24 months). RESULTS The expression of the p27kip1 was significantly higher in the long‐term survival group compared with the control (short survival) group (81.41% vs. 31.94%; P < 0.0001). The PMMs of epithelioid histotype had a significantly higher p27kip1 immunoreactivity compared with those of biphasic type (59.24% vs. 38.94%; P = 0.02). In agreement with the data in the literature, the proliferative activity (as detected by MIB‐1 immunoreactivity) was significantly higher in short than long survival PMMs (43.53% vs. 14.11%; P < 0.0001) and in the biphasic histotype than in the epithelioid type (43.19% vs. 26.02%; P = 0.006). CONCLUSIONS The combined expression of high/low p27kip1 and low/high Ki‐67 values identified with 100% specificity and sensitivity long versus short survivors. p27kip1 represents a reliable additional predictive factor for PMMs and a useful marker to identify patients having a more favorable prognosis. Cancer 2001;92:1245–50. © 2001 American Cancer Society.

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p27kip1 Expression in Rectal Cancer Correlates with Disease-Free Survival

Cited by 20 publications

References 19 publications

Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 (Kip1) in estrogen-related endometrial adenocarcinomas

Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 (Kip1) in estrogen-related endometrial adenocarcinomas

Management of early rectal cancer

p27kip1 immunoreactivity correlates with long-term survival in pleural malignant mesothelioma

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