p210^BCR‐ABL1‐ Chronic myeloid leukemia presents with monocytosis

Abstract

Rare cases of CML present with monocytosis as well as morphologic dysplasia and harbor p210 BCR-ABL1 . Cytogenetic and molecular studies must be performed to confirm the diagnosis of this kind of CML. K E Y W O R D Schronic myeloid leukemia, monocytosis, p210 BCR-ABL

An interesting case of chronic myeloid leukemia (CML) with T315I mutation raising suspicion of de novo AML, a diagnostic conundrum

“…In the literature, it has been mentioned that it is quite rare and challenging to diagnose CML‐BP with monocytic differentiation and therefore karyotyping and/or molecular studies to confirm the diagnosis for further TKIs targeted therapy 10 …”

“…5,6,8,9 In the literature, it has been mentioned that it is quite rare and challenging to diagnose CML-BP with monocytic differentiation and therefore karyotyping and/or molecular studies to confirm the diagnosis for further TKIs targeted therapy. 10 Although the myeloid blast phase is quite common, the monocytic blast phase of CML associated with T315I is the first case reported in our National Center for Cancer care and research institute (NCCCR) in Qatar.…”

The Activity of Novel BCR-ABL Small-Molecule Degraders Containing Pyrimidine Rings and Their Role in Overcoming Drug Resistance

“…e Bcr-abl fusion gene encodes a pathogenic protein (p210BCR-ABL) that continuously increases tyrosine kinase activity and activates multiple downstream signaling pathways to promote the occurrence and development of myeloid leukemia (chronic myeloid leukemia, CML) [25][26][27]. BCR-ABL kinase is closely related to SRCfamily kinases (SFK), which make up the largest nonreceptor tyrosine kinase family in the human body, including LYN, FYN, LCK, HCK, FGR, BLK, YRK, YES, and c-SRC [28][29][30][31][32][33].…”

Cytological Diagnosis of Classic Myeloproliferative Neoplasms at the Age of Molecular Biology

“…Occasionally in CML and especially in Acute Lymphoblastic Leukemia (ALL), a BCR-ABL1 protein of 190kDa (m-BCR) is found due to a breakpoint in exon 1 (e1a2). This protein is also observed in rare cases of CML with monocytosis as well as the p210kDa protein [ 112 , 113 , 114 ]. The research of BCR::ABL1 is an important step for differential diagnosis in the case of persistent leukocytosis and/or thrombocytosis (after eliminating reactional events), notably, if there are few myeloid precursors.…”