P210 Azathioprine versus azathioprine plus metronidazole for the prevention of postoperative endoscopic recurrence of Crohn's disease: A randomized, placebo-controlled trial

Mañosa, Míriam; Cabré, E.; Bernal, Isabel; Esteve, María; Planella, E. Garcia; Gomez, Elena; Peñalva, Mireia; Cortés, Xavier; Boix, Jaume; Piñol, Marta; Gassull, M.A.; Domènech, Eugeni

doi:10.1016/s1873-9946(12)60230-x

Cited by 8 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether patients are on preventive medical therapy or not, it is also often advised to perform early endoscopic monitoring to consider treatment escalation in case of early ER. Despite this approach, up to 50% of patients on thiopurines for post‐surgical recurrence prevention may show ER within the first year following surgery, and it has been shown that this percentage may increase over time . For this reason, therapeutic strategies in patients with subclinical ER despite prevention should be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Addition of mesalazine for subclinical post‐surgical endoscopic recurrence of Crohn's disease despite preventive thiopurine therapy: A case–control study

Zabana

Mañosa

Cabré

et al. 2014

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Addition of mesalazine for subclinical post‐surgical endoscopic recurrence of Crohn's disease despite preventive thiopurine therapy: A case–control study

Zabana

Mañosa

Cabré

et al. 2014

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…42 However, another study showed that, in patients treated with azathioprine versus azathioprine plus metronidazole, there was no difference in endoscopic recurrence (p = 0.15) at 1 year postoperatively. 43 Other antibiotic classes have been investigated with limited success. For example, ciprofloxacin does not appear to be effective in preventing POR.…”

Section: Antibioticsmentioning

confidence: 99%

Medical therapies for postoperative Crohn’s disease

Shah

Click

2021

Therap Adv Gastroenterol

View full text Add to dashboard Cite

Postoperative recurrence of Crohn’s disease is common and requires a multidisciplinary approach between surgeons and gastroenterologists in the perioperative and postoperative period to improve outcomes in this patient population. Endoscopic recurrence precedes clinical and surgical recurrence and endoscopic monitoring is crucial to guide postoperative management. Risk stratification of patients is recommended to guide early prophylactic management, and follow-up endoscopic monitoring can guide intensification of therapy. This review summarizes evidence behind postoperative recurrence rates, disease monitoring techniques, nonbiologic and biologic therapies available to prevent and treat postoperative recurrence, risk factors associated with recurrence, and postoperative management strategies guided by endoscopic monitoring.

show abstract

“…Five RCTs investigated the effect of prolonged courses of antibiotics in prevention of post-operative recurrence of CD (106,(108)(109)(110)(111). Nitroimidazoles have been shown to be effective in reducing clinical (RR, 0.23; 95% CI: 0.09-0.57, NNT =4) and endoscopic (RR, 0.44; 95% CI: 0.26-0.74; NNT =4) recurrence (112).…”

Section: Post-operative Prophylaxismentioning

confidence: 99%

Antibiotics in inflammatory bowel diseases: do we know what we’re doing?

Ledder

2019

Transl Pediatr

View full text Add to dashboard Cite

Despite the revolution in inflammatory bowel disease (IBD) treatment over the past two decades with the advent of biological therapies, there remains a substantial proportion of patients with inadequate or unsustained response to existent therapies. The overwhelming focus of IBD therapeutics has been targeting mucosal immunity, however with the developing evidence base pointing to the role of gut microbes in the inflammatory process, renewed focus should be placed on the impact of manipulating the microbiome in IBD management. This review provides an overview of the evidence implicating bacteria in the pathogenesis of gut inflammation in IBD and provides an overview of the evidence of antibiotics in IBD treatment. We also suggest a potential role of antibiotics in clinical practice based on available evidence and clinical experience.

show abstract

P210 Azathioprine versus azathioprine plus metronidazole for the prevention of postoperative endoscopic recurrence of Crohn's disease: A randomized, placebo-controlled trial

Cited by 8 publications

References 0 publications

Addition of mesalazine for subclinical post‐surgical endoscopic recurrence of Crohn's disease despite preventive thiopurine therapy: A case–control study

Addition of mesalazine for subclinical post‐surgical endoscopic recurrence of Crohn's disease despite preventive thiopurine therapy: A case–control study

Medical therapies for postoperative Crohn’s disease

Antibiotics in inflammatory bowel diseases: do we know what we’re doing?

Contact Info

Product

Resources

About