P2‐217: Silver nanoparticles as alternate strategies for drug delivery to Alzheimer brain

Aliev, Gjumrakch; Daza, Jesús; Lipsitt, Amanda; Martínez-Agüero, María; Palacios, Hector H.; Fischbach, Kathryn; Obrenovich, Mark E.; LaManna, Joseph C.; Bragin, Valentin; Morales, Ludis

doi:10.1016/j.jalz.2009.04.530

Cited by 8 publications

(4 citation statements)

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“…This can be attributed to the cohesion between the nanoparticles surface and the microbial cells, and hence is found to be size dependent. AgNP are currently used as active drug in targeted drug delivery [6], gene delivery [7] and artificial implants [8] and as a diagnostic agent in imaging and sensors for detection of different diseases in their early stages. Owing to their mutation-resistant antimicrobial activity, they are being used in different pharmaceutical formulations as antibacterial clothing [9], burn ointments [10] and as coating for medical devices [11].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Rapid Extracellular Biosynthesis of Silver Nanoparticles Using Carom Seed (Trachyspermum copticum) Extract and in Vitro Studies

Deshpande¹,

Borgaonkar²,

Bendegumble³

et al. 2011

AJAC

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Microwave-assisted rapid extracellular biosynthesis of silver nanoparticles was carried out by using carom seed (Trachyspermum copticum) extract as the reducing agent. The reaction mixture containing AgNO 3 and carom seed extract when exposed to microwave irradiation resulted in reducing silver ions to bio-functionalized silver nanoparticles of size 6-50 nm. The AgNP were characterized by UV-vis spectroscopy (UV-vis), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDAX), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM). Themogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FTIR) are used to understand the possible mechanism of biosynthesis. In this study, we have also investigated the antimicrobial and antioxidant activities of bio-functionalized AgNP. The antibacterial activity is investigated by measuring the zone of inhibition and antioxidant study is done using 1,1-diphenyl-2-picryl hydrazyl (DPPH) method.

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Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Rapid Extracellular Biosynthesis of Silver Nanoparticles Using Carom Seed (Trachyspermum copticum) Extract and in Vitro Studies

Deshpande¹,

Borgaonkar²,

Bendegumble³

et al. 2011

AJAC

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“…Since silver (Ag) nanoparticles present excellent antimicrobial properties, they are an obvious choice for increasing the antibacterial activity by adding a filler [323][324][325]. AgNPs are also toxic to cancerous cells [326] and are also feasible aspirants in drug delivery [327][328][329]. However, the tendency presented by this nanoparticle for agglomeration during the reduction of its metallic salts makes its use in the biological field inappropriate.…”

Section: Therapeutic Metal Ions (Tmis)mentioning

confidence: 99%

A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment

et al. 2020

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Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties— biocompatibility, biodegradability, non-toxicity, antibacterial activity, the capacity to form films, and chelating of metal ions. Most of these peculiar properties are attributed to the presence of free protonable amino groups along the chitosan backbone, which also gives it solubility in acidic conditions. Moreover, this biopolymer can also be physically modified, thereby presenting a variety of forms to be developed. Consequently, this polysaccharide is used in various fields, such as tissue engineering, drug delivery systems, and cancer treatment. In this sense, this review aims to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications. We present the most relevant and new information about this polysaccharide-based biomaterial’s applications in distinct fields and also the ability of chitosan and its various derivatives to selectively permeate through the cancer cell membranes and exhibit anticancer activity, and the possibility of adding several therapeutic metal ions as a strategy to improve the therapeutic potential of this polymer.

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“…The obtained AgNPs was further loaded with doxorubicin (DOX), a FDA approved anticancer drug, to design a DOX-loaded drug delivery system (Au-DOX). Administration of this DDS to breast cancer cells (MCF-7 and MDA-MB-231) shows significant inhibition of breast cancer cell proliferation compared to naked doxorubicin [24]. Moreover, the use of nanoparticles in drug delivery therapy holds much promise in targeting remote tissues, including brain tissue affected by Alzheimer disease.…”

Section: Ease Of Synthesismentioning

confidence: 99%

Photosynthesis vs. Traditional Chemical Synthesis for Obtaining Biocompatible Drug Delivery (Dds) Nanoparticles: A Review.

Salma¹,

Ibrahium²

2017

IJAR

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P2‐217: Silver nanoparticles as alternate strategies for drug delivery to Alzheimer brain

Cited by 8 publications

References 0 publications

Microwave-Assisted Rapid Extracellular Biosynthesis of Silver Nanoparticles Using Carom Seed (Trachyspermum copticum) Extract and in Vitro Studies

Microwave-Assisted Rapid Extracellular Biosynthesis of Silver Nanoparticles Using Carom Seed (Trachyspermum copticum) Extract and in Vitro Studies

A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment

Photosynthesis vs. Traditional Chemical Synthesis for Obtaining Biocompatible Drug Delivery (Dds) Nanoparticles: A Review.

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