P2-11: Anti obesogenic effects of apple cider vinegar in rats subjected to a high fat diet

Bouderbala, H.; Kaddouri, H.; Maharrar, M.; Khéroua, O.; Saïdi, D.

doi:10.1016/s0003-3928(16)30058-0

Cited by 11 publications

(11 citation statements)

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“…This study is in agreement with the work of Bourderbala et al [27] who demonstrated how apple vinegar can have a significant impact on the lipid profile of rats subjected to high-fat diet.…”

Section: Discussionsupporting

confidence: 93%

The Effect of Apple Cider Vinegar on the Lipid Profile and Electrolytes of Wistar Rats

Okoye

Porolo

2019

JABB

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Aim: This study was to investigate the effects of apple cider vinegar with “the mother” on lipid profile and electrolytes of Wistar rats. Materials and Methods: Twelve female albino rats with mean weight of 150±20 were grouped into four groups. The first group was the control. The control was given distilled water and allowed access to normal animal feed ad libitum but was not administered apple cider vinegar. The second group was the group to be sacrificed after the first week of experiment. The group was given distilled water, allowed access to normal animal feed ad libitum and administered 1ml apple cider vinegar solution twice daily. The third group was the group to be sacrificed after the second week of experiment. The group had same treatment as the second group above. The fourth group was the group to be sacrificed after the third week which was the final week of experiment. The group had same treatment like the second and third groups. Results: After oral administration of the apple cider vinegar on rats for 7 days up to 21 days, the results revealed that the significant reductions in a time dependent manner with the highest reductions obtained on the last week of experiment (p<0.05). After 21 days, triglycerides reduced from 3.37 ± 0.14 to 2.73 ± 0.13 mmol/l, total cholesterol from 4.04 ± 0.98 to 3.62 ± 0.33, low density lipoprotein cholesterol from 8.24 ± 1.31 to 7.02 ± 0.30, very low density lipoprotein cholesterol from 1.55 ± 0.07 to 1.42 ± 0.04mmol/l in the blood of rats. It also revealed a significant decrease (p< 0.05) in calcium electrolyte concentration from 11.54 ± 0.21 to 7.09 ± 0.20 mmol/l. It also revealed significant decrease (p<0.05) in the sodium and elevation in potassium electrolytes concentrations from 153.63 ±0.24 to 120.30 ± 1.31 and 3.61 ± 0.30 to 4.92± 0.46 mmol/l respectively. Conclusion: The results suggested that the apple cider vinegar reduced triglycerides and cholesterol levels in the blood of Wistar rats. The results also suggested that apple cider vinegar reduced calcium and sodium electrolyte levels in the blood but increased potassium levels in the blood of Wistar rats based on the 1ml administration for 21 days.

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Section: Discussionsupporting

confidence: 93%

The Effect of Apple Cider Vinegar on the Lipid Profile and Electrolytes of Wistar Rats

Okoye

Porolo

2019

JABB

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“…Human studies are supported in part by studies in rodents. In the context of high-fat diet (HFD)-induced metabolic disorders, vinegar ingestion by rats induces satiety and is hypolipidemic, hypoglycemic, anti-obesogenic [ 104 , 105 ], and anti-hypertensive [ 106 ], an effect that has not been tested in humans. In rats receiving a HFD, vinegar suppresses obesity-induced oxidative stress by modulating anti-oxidant defense systems and reverses HFD-induced obesity, hyperlipidemia, and oxidative stress [ 107 ].…”

Section: Acetate In Foodsmentioning

confidence: 99%

The Alcohol–High-Density Lipoprotein Athero-Protective Axis

et al. 2020

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Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an effect that has been attributed to the concurrent elevations of plasma high-density lipoprotein-cholesterol (HDL-C) concentrations. More recent evidence has accrued against the hypothesis that raising plasma HDL concentrations prevents ASCVD so that other metabolic processes associated with alcohol consumption have been considered. This review explored the roles of other metabolites induced by alcohol consumption—triglyceride-rich lipoproteins, non-esterified free fatty acids, and acetate, the terminal alcohol metabolite in athero-protection: Current evidence suggests that acetate has a key role in athero-protection but additional studies are needed.

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“…Bouderbala et al (12) demonstrated that acetic acid may help prevent the accumulation of body fat and some fats in the liver, indicating that the metabolic disturbances caused by a high-fat diet would be regulated due to the effect of satiety by consuming apple cider vinegar. It also reduces fats and glucose in the blood.…”

Section: Introductionmentioning

confidence: 99%

Comparison Study between Drugs (Orlistat and Chitocal) and Food Supplements (Green Tea and Apple Cider Vinegar) for Weight Loss and Hepatoprotection in Rats

Bukhari

Zahran²,

Bakr³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Obesity is a major problem in Saudi Arabia. Pharmaceutical solutions were sought for treatment. Chemical formula might lead to major health side effects. Meanwhile, the use of herbal formula is alleged to be safe. Green tea and apple vinegar are some of these products. Objective: The study aimed to measure the effect of green tea and apple vinegar on obesity and liver status compared to medical drugs. Materials and methods: Thirty-six adult male albino rats were divided into normal control, and other five groups fed on high caloric and hyperlipidemic diets. They were control positive and the rest 4 groups were treated with different formula (green tea, apple cider vinegar, orlistat and chitocal). Results: All treated groups showed significant decrease in body weight when compared to control positive. Rats administered with orlistat and chitocal showed the highest significant decrease in body weight gain (BWG) when compared to control positive. Moreover, all tested groups enhanced liver functions especially chitocal and apple cider vinegar groups which showed the highest effect in ALT. Orlistat and green tea groups came in second level. Conclusion:Although, no poor effect of chemical drugs found, natural products can provide the positive effect with no risk. Apple cider vinegar was the best natural weight control formula.

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P2-11: Anti obesogenic effects of apple cider vinegar in rats subjected to a high fat diet

Cited by 11 publications

References 0 publications

The Effect of Apple Cider Vinegar on the Lipid Profile and Electrolytes of Wistar Rats

The Effect of Apple Cider Vinegar on the Lipid Profile and Electrolytes of Wistar Rats

The Alcohol–High-Density Lipoprotein Athero-Protective Axis

Comparison Study between Drugs (Orlistat and Chitocal) and Food Supplements (Green Tea and Apple Cider Vinegar) for Weight Loss and Hepatoprotection in Rats

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