The Alcohol–High-Density Lipoprotein Athero-Protective Axis

Rosales, Corina; Gillard, Baiba K.; Gotto, Antonio M.; Pownall, Henry J.

doi:10.3390/biom10070987

Cited by 8 publications

(7 citation statements)

References 113 publications

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“…In contrast, habitual alcohol consumption, an acquired lifestyle, raises serum HDL-C levels [25,26]. The amount and frequency of alcohol consumption were higher in groups with higher HDL-C levels in this study.…”

Section: Discussioncontrasting

confidence: 58%

“…Logistic regression models were used to examine the associations between proteinuria and levels of HDL-C, with adjustment for relevant confounding factors including age, sex, pharmacotherapy (for hypertension, diabetes, and dyslipidemia), current smoking, alcohol consumption, regular exercise, serum triglyceride level, and BMI, yielding odds ratios (ORs) and 95% confidence intervals (CIs). Because alcohol consumption raises serum HDL-C levels [25,26], we conducted the same analysis by restricting participants to those who consumed very small amounts of alcohol or no alcohol. Among all participants in the cross-sectional study, participants who did not have proteinuria at baseline were enrolled in the cohort study.…”

Section: Discussionmentioning

confidence: 99%

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U-Shaped Relationship Between Proteinuria and High-Density Lipoprotein Cholesterol: Results of Cross-Sectional and Six Years Cohort Studies (KITCHEN-10)

Igata

Nakajima

2022

J Clin Med Res

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Background: Although a very high level of high-density lipoprotein cholesterol (HDL-C) may be a potential cardiovascular disease risk factor, the detail and underlying mechanism remain unclear. Therefore, we examined the associations of serum HDL-C with the incidence of proteinuria, a predictor for cardiovascular disease, in a community-based study. Methods:We investigated clinical parameters, including serum HDL-C and proteinuria, among 1,191,409 people aged 40 -74 years who underwent a health checkup in a cross-sectional study. In the cohort study, the incidence of proteinuria after 6 years was investigated in 451,987 participants without proteinuria at baseline, who were simultaneously enrolled in the cross-sectional study. Results:The prevalence of proteinuria showed a U-shaped relationship with 10 HDL-C categories, with a minimum of 60 -89 mg/dL in the cross-sectional study. Logistic regression analysis showed similar U-shaped relationships between odds ratios for proteinuria and HDL-C categories, with a minimum of 70 -79 mg/dL. The associations between very high HDL-C (≥ 90 mg/dL) and proteinuria were strengthened after adjustment for body mass index (BMI). In the cohort study, a crude L-shaped relationship was observed between the incidence of proteinuria and baseline HDL-C, which turned into U-shaped relationship after adjustment for baseline BMI and HDL-C after 6 years.Conclusions: Low and very high levels of HDL-C may be associated with the incidence of proteinuria, and BMI may be a potent contributing factor to the underlying mechanism.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

U-Shaped Relationship Between Proteinuria and High-Density Lipoprotein Cholesterol: Results of Cross-Sectional and Six Years Cohort Studies (KITCHEN-10)

Igata

Nakajima

2022

J Clin Med Res

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“…Several mechanisms have been proposed as involved in the positive health effect of moderate alcohol consumption, from beneficial effects on lipoprotein metabolism (including an increase in high-density lipoprotein (HDL) [ 19 , 20 ], hemostasis (thrombogenesis and fibrinolytic activity) [ 21 , 22 ] and inflammatory processes [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Alcohol Intake and Arterial Stiffness in Healthy Adults: A Systematic Review

et al. 2022

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Background: Arterial stiffness as assessed by Pulse Wave Velocity (PWV) represents an independent predictor of cardiovascular disease. Several dietary compounds and lifestyle factors could influence arterial stiffness. The debate on the significance of the correlation between alcohol consumption and arterial stiffness is still open, given that the relationship is complex and potentially affected by several factors such as alcohol type, consumption levels, gender and age differences. Objective: This systematic literature review aims to examine the evidence supporting an association between alcohol use and PWV, in electronic databases including PubMed/MEDLINE and the Cochrane Library, from January 2010 to November 2020. Screening and full-text reviews were performed by three investigators and data extraction by two. Considering the significant heterogeneity of data only a qualitative analysis (systematic review) was performed. Results: A total of 13 studies met the inclusion criteria. Alcohol consumption was independently associated with arterial stiffness in a J-shaped way in most of the studies included. A benefit of alcohol consumption on arterial stiffness was found in four experimental studies, whilst an unfavorable increasing linear association was found in four others. Associations were confirmed with both oscillometric and tonometric PWV assessment methods. In some studies, a gender and age correlation was found with a more pronounced association in older males. In all studies elevated levels of alcohol consumption were associated with a worsening of arterial stiffness. Conclusions: Despite the variable findings across studies, the current review provides preliminary evidence that light-to-moderate alcohol consumption is associated with arterial stiffness values lower than expected, and evidence that high doses accelerate arterial ageing. These findings could be useful for clinicians who provide recommendations for patients at cardiovascular (CV) risk. Nevertheless, given the heterogeneity of study designs, interventions, measurement methods and statistical evaluations, the protective role of moderate alcohol consumption on arterial stiffness is likely but not certain, warranting additional trials and evidence.

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“…This is consistent with the above studies and dietary guidelines. The causal relationship between regular low alcohol consumption and prevention of CVD was supported by some biomedical evidence, which is mediated by anti-inflammatory effects, reduction of fibrinogen levels, inhibition of platelet activation and increased high-density lipoprotein level by terminal alcohol metabolite ( 100 – 102 ). The beneficial effects of alcohol on CVD account for 77.8% of the total beneficial effects of alcohol ( 103 ), and ACM includes deaths caused by CVD, so it is reasonable that low/moderate alcohol consumption leads to a decrease in ACM in hypertensive patients.…”

Section: Discussionmentioning

confidence: 92%

Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies

Zhong

Chen

Wang

et al. 2022

Front. Public Health

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An umbrella review of meta-analyses was performed to summarize the evidence of associations between alcohol consumption and health outcomes and to assess its credibility. Meta-analyses of prospective cohort studies reporting the associations of alcohol consumption with health outcomes were identified. We recalculated the random-effects summary effect size and 95% confidence interval, heterogeneity, and small-study effect for each meta-analysis and graded the evidence. Fifty-nine publications reporting 224 meta-analyses of prospective cohort studies with 140 unique health outcomes were included, in which there were 49 beneficial associations and 25 harmful associations with nominally statistically significant summary results. But quality of evidence was rated high only for seven beneficial associations (renal cell carcinoma risk, dementia risk, colorectal cancer mortality, and all-cause mortality in patients with hypertension for low alcohol consumption; renal cell carcinoma risk, cardiovascular disease (CVD) risk in patients with hypertension and all-cause mortality in patients with hypertension for moderate consumption) and four harmful associations (cutaneous basal cell carcinoma risk for low alcohol consumption; cutaneous basal cell carcinoma risk and cutaneous squamous cell carcinoma risk for moderate alcohol consumption; hemorrhagic stroke risk for high alcohol consumption). In this umbrella review, only 11 health outcomes (5 in low alcohol consumption, 5 in moderate alcohol consumption and 1 in high alcohol consumption) with statistically significant showed high quality of epidemiologic evidence. More robust and larger prospective studies are needed to verify our results.

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The Alcohol–High-Density Lipoprotein Athero-Protective Axis

Cited by 8 publications

References 113 publications

U-Shaped Relationship Between Proteinuria and High-Density Lipoprotein Cholesterol: Results of Cross-Sectional and Six Years Cohort Studies (KITCHEN-10)

U-Shaped Relationship Between Proteinuria and High-Density Lipoprotein Cholesterol: Results of Cross-Sectional and Six Years Cohort Studies (KITCHEN-10)

Association between Alcohol Intake and Arterial Stiffness in Healthy Adults: A Systematic Review

Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies

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