P2‐007: Longitudinal reproducibility of default‐mode network connectivity in healthy elderly participants: A multicentric resting‐state fMRI study

Jovicich, Jorge; Minati, Ludovico; Marizzoni, Moira; Nobili, Flavio; Didic, Mira; Bartres, David; Fiedler, Ute; Schönknecht, Peter; Payoux, Pierre; Beltramello, Alberto; Soricelli, Andrea; Parnetti, Lucilla; Tsolaki, Magda; Rossini, Paolo Maria; Scheltens, Nienke M.E.; Forloni, Gianluigi; Bordet, Régis; Blin, Olivier; Frisoni, Giovanni B.

doi:10.1016/j.jalz.2015.06.543

Cited by 6 publications

(7 citation statements)

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“…Identical scanning parameters were used at both sites. Biomedical Informatic Research Network (Jovicich et al, ) optimized sequences were used to acquire T1‐weighted magnetization‐prepared rapid‐acquisition gradient‐echo (MPRAGE) sequence scan (repetition time (TR) = 2170 ms, echo time (TE) = 4.33 ms, slice thickness = 1.2 mm, sagittal slice number = 160, and 256‐mm field of view (FOV)). T2*‐sensitive echo planar pulse sequences were used to acquire functional images (TR = 2,500 ms, TE = 30 ms, slice thickness = 4‐mm, axial slice number = 38, FOV = 200 mm, flip angle = 90°, and 3.1 × 3.1 × 4.0 mm voxels).…”

Section: Methodsmentioning

confidence: 99%

Combined effects of peer presence, social cues, and rewards on cognitive control in adolescents

Breiner

Cohen

et al. 2018

Developmental Psychobiology

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Developmental scientists have examined the independent effects of peer presence, social cues, and rewards on adolescent decision-making and cognitive control. Yet, these contextual factors often co-occur in real world social situations. The current study examined the combined effects of all three factors on cognitive control, and its underlying neural circuitry, using a task to better capture adolescents' real world social interactions. A sample of 176 participants ages 13-25, was scanned while performing an adapted go/no-go task alone or in the presence of a virtual peer. The task included brief positive social cues and sustained periods of positive arousal. Adolescents showed diminished cognitive control to positive social cues when anticipating a reward in the presence of peers relative to when alone, a pattern not observed in older participants. This behavioral pattern was paralleled by enhanced orbitofrontal activation. The results demonstrate the synergistic impact of social and reward influences on cognitive control in adolescents.

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Section: Methodsmentioning

confidence: 99%

Combined effects of peer presence, social cues, and rewards on cognitive control in adolescents

Breiner

Cohen

et al. 2018

Developmental Psychobiology

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“…Temporal filtering was used consistently with common practice and works implementing FSL‐FIX [Griffanti et al, ]. Spatial smoothing was also performed, since it returned high reproducibility of the tSNR across multiple sites in our previous works [Jovicich et al ]. Single‐subject ICA was run with automatic estimation of dimensionality using MELODIC on preprocessed data including the brain‐extracted anatomical images.…”

Section: Methodsmentioning

confidence: 99%

Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques

et al. 2016

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Understanding how to reduce the influence of physiological noise in resting state fMRI data is important for the interpretation of functional brain connectivity. Limited data is currently available to assess the performance of physiological noise correction techniques, in particular when evaluating longitudinal changes in the default mode network (DMN) of healthy elderly participants. In this 3T harmonized multisite fMRI study, we investigated how different retrospective physiological noise correction (rPNC) methods influence the within-site test-retest reliability and the across-site reproducibility consistency of DMN-derived measurements across 13 MRI sites. Elderly participants were scanned twice at least a week apart (five participants per site). The rPNC methods were: none (NPC), Tissue-based regression, PESTICA and FSL-FIX. The DMN at the single subject level was robustly identified using ICA methods in all rPNC conditions. The methods significantly affected the mean z-scores and, albeit less markedly, the cluster-size in the DMN; in particular, FSL-FIX tended to increase the DMN z-scores compared to others. Within-site test-retest reliability was consistent across sites, with no differences across rPNC methods. The absolute percent errors were in the range of 5-11% for DMN z-scores and cluster-size reliability. DMN pattern overlap was in the range 60-65%. In particular, no rPNC method showed a significant reliability improvement relative to NPC. However, FSL-FIX and Tissue-based physiological correction methods showed both similar and significant improvements of reproducibility consistency across the consortium (ICC = 0.67) for the DMN z-scores relative to NPC. Overall these findings support the use of rPNC methods like tissue-based or FSL-FIX to characterize multisite longitudinal changes of intrinsic functional connectivity. Hum Brain Mapp 37:2114-2132, 2016. © 2016 Wiley Periodicals, Inc.

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“…Changes in large-scale networks connectivity between the two groups were assessed with the Jaccard similarity coefficient (JSC), a well-established metric, also previously adopted for large-scale networks comparison (e.g., (Jovicich et al, 2016;Karahano glu & Van De Ville, 2015). JSC measures the similarity between large-scale networks by computing the normalized amount of their overlap.…”

Section: [18f]fdg-pet Network Analysismentioning

confidence: 99%

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Sala

Caminiti

Iaccarino

et al. 2019

Human Brain Mapping

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Aberrations of large‐scale brain networks are found in the majority of neurodegenerative disorders. The brain connectivity alterations underlying dementia with Lewy bodies (DLB) remain, however, still elusive, with contrasting results possibly due to the pathological and clinical heterogeneity characterizing this disorder. Here, we provide a molecular assessment of brain network alterations, based on cerebral metabolic measurements as proxies of synaptic activity and density, in a large cohort of DLB patients (N = 72). We applied a seed‐based interregional correlation analysis approach (p < .01, false discovery rate corrected) to evaluate large‐scale resting‐state networks' integrity and their interactions. We found both local and long‐distance metabolic connectivity alterations, affecting the posterior cortical networks, that is, primary visual and the posterior default mode network, as well as the limbic and attention networks, suggesting a widespread derangement of the brain connectome. Notably, patients with the lowest visual and attention cognitive scores showed the most severe connectivity derangement in regions of the primary visual network. In addition, network‐level alterations were differentially associated with the core clinical manifestations, namely, hallucinations with more severe metabolic dysfunction of the attention and visual networks, and rapid eye movement sleep behavior disorder with alterations of connectivity of attention and subcortical networks. These multiple network‐level vulnerabilities may modulate the core clinical and cognitive features of DLB and suggest that DLB should be considered as a complex multinetwork disorder.

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P2‐007: Longitudinal reproducibility of default‐mode network connectivity in healthy elderly participants: A multicentric resting‐state fMRI study

Cited by 6 publications

References 0 publications

Combined effects of peer presence, social cues, and rewards on cognitive control in adolescents

Combined effects of peer presence, social cues, and rewards on cognitive control in adolescents

Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

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