P178. Assessment of tissue eosinophilia in head and neck squamous cell carcinoma by Luna staining

Rahrotaban, Sedigheh; Khatibi, Amirhossein; Allami, Abbas

doi:10.1016/j.oraloncology.2011.06.421

Cited by 7 publications

(10 citation statements)

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“…Our findings are in accordance with studies by Alkhabuli and High, [9] where they did not find significant difference between density of eosinophils and SCC differentiation. Similar finding has been recorded by Tadbir et al [7] and Rahrotaban et al, [31] they also observed lower TATE count in poorly differentiated group.…”

Section: Discussionsupporting

confidence: 90%

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Shrestha

Narayan

Kumar

et al. 2020

JGOH

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Objectives: Squamous cell carcinoma of the oral cavity is the most common aggressive epithelial malignant neoplasm. Its biological behavior is influenced by the host immune cells, such as multifaceted eosinophils, associated with wound healing and tissue damage processes. Their presence within a variety of human cancers raises queries about their role. The infiltrations of tumor stroma by eosinophils are believed to play a significant role in progression of the carcinoma and could be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. Its role in cancer still remains unclear since in the literature, there are very few studies showing improved prognosis and few contradictory studies showing poor prognosis. This study was conducted with an aim to compare the tumor-associated tissue eosinophilia in oral squamous cell carcinoma (OSCC) and normal tissue and to correlate the expression in different grades of carcinoma using a special stain that targets eosinophils exclusively and vividly. Materials and Methods: The study includes 30 samples, six normal, and 24 histopathologically diagnosed with OSCC. 5 μ thick sections were made and stained using special stain and examined under high power (×40), ten consecutive microscopic fields were studied. The average numbers of eosinophils were statistically analyzed. Results: Eosinophil count for carcinoma was higher compared to normal mucosa, but the comparison in different grades of cancer did not show much difference. Conclusion: Since eosinophil count was higher in carcinoma, eosinophil infiltration in dysplastic cases should prompt thorough evaluation for invasiveness.

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Section: Discussionsupporting

confidence: 90%

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Shrestha

Narayan

Kumar

et al. 2020

JGOH

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“…The average eosinophil count in HNSCC samples was 143.56 eosinophil/10HPF, which was higher than those of other studies (14,16,17), which can be due to the different staining method used. It is defined that Sirius Red staining has higher specificity and contrast to show eosinophils compared to Luna, Congo red and hematoxylin and eosin staining (12).…”

Section: Discussioncontrasting

confidence: 67%

“…2015; 1(1):e5634. eosinophil count (17). Jain et al evaluated the relationship between histopathologic grading and eosinophil count in metastatic and non-metastatic oral SCC and showed that in well and moderate differentiated metastatic SCC there is a less average eosinophilic count compared to nonmetastatic ones (14).…”

Section: Discussionmentioning

confidence: 99%

Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck

Saravani¹,

Kadeh²,

Derakhshanfar³

2015

DCEJ

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Background: Tumor-associated tissue eosinophilia (TATE) is reported in different cancers of human body but its exact role is not yet defined in head and neck squamous cell carcinoma (HNSCC). Objectives: The current study aimed to assess the relationship between TATE and histopathologic grading, age and gender of patients with HNSCC. Materials and Methods:In this cross-sectional study, 90 paraffin-embedded blocks of HNSCC samples were sectioned and stained with Sirius red (a histochemical staining). Then the eosinophils were counted in 10 high power fields with magnification of 400x (eosinophil/10HPF). Data were analyzed using Mann-Whitney, Kruskal-Wallis and the Spearman correlation tests by SPSS software version 21.0. Results: The mean age of the samples was 60.23 years, 46.67% of the samples were male and 53.33% were female. Histopathologically, 51 cases were grade1 (56.67%), 25 cases were grade 2 (27.78%) and 14 cases were grade 3 (15.55%). The average eosinophil count in all

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“…Similar, finding has been recorded by Tadbir et al and Rahrotaban et al, but it was lower in poorly differentiated group. 8,17 According to Jain M et al, non-metastatic group with well and moderately differentiated tumor had higher mean eosinophilic count than metastatic group. In the metastatic group, well differentiated carcinoma had higher TATE count than moderately differentiated.…”

Section: Discussionmentioning

confidence: 99%

Assessment of role of eosinophils in the progression of tongue carcinoma

Hallikeri¹,

Acharya²,

Chatni³

et al. 2016

Asian J Med Sci

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Background: Tumor associated tissue eosinophilia (TATE) is known as stromal infiltration of eosinophils in the stroma of tumor not associated with tumor necrosis or ulceration. It has been described in a variety of neoplasms, but the role in oral squamous cell carcinoma (OSCC) of tongue has not yet been clearly defined. Association of TATE with OSCC has shown variable results ranging from favorable to unfavorable or even no influence on prognosis.Aims and Objectives: The aim of the present study was to correlate TATE with histopathological grades, lymph node status, tumor thickness and nature of tumor cells at the invasive front in OSCC of tongue.Material and Methods: Retrospectively fifty six cases of OSCC of tongue treated with radical neck dissection were included, which were divided into Group I consists 22 cases (lymph node with metastasis) & Group II consists 34 cases (lymph node without metastasis). H & E stained sections were used to analyze TATE and compared with histopathological grades, lymph node status, tumor thickness and nature of invasive front. Statistical analysis was done using Chi-square test.Results: TATE did not have any significant association with histopathological grades, lymph node status and nature of tumor cells at invasive front. But, tumor thickness and presence of eosinophils showed significant association. Also as the tumor thickness increased, the cells were more discohesive at the invasive front region.Conclusion: Microenvironment of tumor significantly contributes in the tumor progression. Tumor thickness, nature of tumor cells at the invasive front and TATE together can help in assessing the behavior of tongue squamous cell carcinoma.Asian Journal of Medical Sciences Vol.7(5) 2016 17-21

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P178. Assessment of tissue eosinophilia in head and neck squamous cell carcinoma by Luna staining

Cited by 7 publications

References 0 publications

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Tumor-associated tissue eosinophilia in oral squamous cell carcinoma – A predictable biological behavior

Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck

Assessment of role of eosinophils in the progression of tongue carcinoma

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