Abstract:Background: Early diagnosis of cervical intraepithelial neoplasia and prevention of its malignant progression is very important. The interaction between human papillomavirus (HPV) oncogenic proteins and the cellular regulatory proteins leads to the upregulation of p16INK4a. Overexpression of p16INK4a is a surrogate biomarker of HPV infection leading to premalignant or malignant cervical lesions. Aim: In this study, we evaluated the expression of p16INK4a/Ki67 in correlation with HPV genotypes to find out their… Show more
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