P1250 Infiuence of Lactobacilli probiotic strains on apoptosis of colon cancer cells lines

Gonet-Surówka, Agnieszka; Strus, Magdalena; Heczko, Piotr B

doi:10.1016/s0924-8579(07)71090-7

Cited by 9 publications

(5 citation statements)

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“…Both the live and heat‐killed forms of some species of LAB had strongly activated pan‐caspases, resulting in colon cancer cell apopotosis (Gonet‐Surowka et al . ; Thirabunyanon et al . ).…”

Section: Discussionmentioning

confidence: 99%

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Moon

Soh

et al. 2012

J Appl Microbiol

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Aims: To investigate the intracellular lipid accumulation inhibitory effect of spent culture medium extract and the cytoplasmic fraction of Weissella koreensis OK1-6 cells isolated from kimchi in differentiating 3T3-L1 cells. Methods and Results: Differentiating 3T3-L1 cells were treated with either cytoplasmic fraction of W. koreensis OK1-6 cells or its spent media for 4 days. Both the spent culture medium extract and cytoplasmic fraction of W. koreensis OK1-6 cells significantly decreased the triglyceride concentration and intracellular lipid accumulation in the treated groups compared with the control group. The mRNA expression levels of C/EBP-a, one of the major transcriptional factors involved in adipocyte differentiation, were significantly less expressed in 3T3-L1 cells treated with the spent medium and cytoplasmic fraction. The expressions of aP2, fatty acid synthase (FAS) and SREBP1 genes were also decreased significantly. Conclusions: These results suggested that W. koreensis OK1-6 could play a crucial role in preventing intracellular lipid accumulation by down-regulating the expression of adipocyte-specific genes C/EBPa, aP2, SREBP1 and FAS. Significance and Impact of the Study: These results may contribute to nutraceutical and food industries in developing probiotic-based therapies for the treatment and prevention of obesity.

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Section: Discussionmentioning

confidence: 99%

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Moon

Soh

et al. 2012

J Appl Microbiol

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“…Ewaschuk et al (2006) concluded that, the conditioned medium of probiotic LAB (VSL3) reduced the viability and induced apoptosis of colon cancer cells (Caco-2 and HT-29). Gonet-Surowka et al (2007) suggested that only some species of lactobacilli were probiotic and that both live and heat-killed forms had strongly activated pan-caspases, resulting in colon cancer cell apoptosis. The action mode of both probiotic strains in our finding might trigger a mechanism in colon cancer cells, resulting in cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Probiotic potential of lactic acid bacteria isolated from fermented dairy milks on antiproliferation of colon cancer cells

2008

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Fifty-four strains of lactic acid bacteria obtained from fermented dairy milks were investigated for possible use as probiotics and for colon cancer biological products. Five of these strains inhibited growth of eight food-borne pathogens including Helicobacter pylori, Escherichia coli, and Salmonella typhimurium. Three of these strains survived at pH 2.5 and in 0.3% bile salts. Additionally they produced no haemolysis, were resistant to kanamycin and adhered to Caco-2 cells. 16S rRNA gene sequences of probiotic strains indicated that RM11 and RM28 were Enterococcus faecium and Lactobacillus fermentum, respectively. Both the cultured medium and live whole cells from probiotic strains were tested for antiproliferation of colon cancer cells through MTT and Trypan Blue exclusion assays. The probiotic strains of E. faecium RM11 and L. fermentum RM28 also triggered antiproliferation of colon cancer cells at the rates of 21-29%, and 22-29%, respectively. This suggested that both strains could be used as potential probiotics in functional food or for colon cancer biological products.

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“…LAB cultures are widely recognized as a type of probiotic that has many health benefits for humans. However, recent research has shown that the biological activity of LAB can be obtained through live or dead bacteria (Gonet‐Surowka et al, 2007 ). Exopolysaccharides (EPS) produced by LAB have specifically found their potential interests, such as essential chemicals and health services (Laiño et al., 2016 ).…”

Section: Prevention Of Apoptosismentioning

confidence: 99%

Nutritional and ethnomedicinal scenario of koumiss: A concurrent review

Afzaal

Saeed

Anjum

et al. 2021

Food Science & Nutrition

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Fermented dairy products have long been known to be a significant component of our nutritious diet, and their therapeutic properties have been recognized since ancient civilization. Evidence suggests that fermented dairy products were produced from about 10,000 BC. Fermentation involves the natural functions of good microbes and their enzymes that can change food into nontoxic foodstuffs with pleasant aroma, taste, texture, and nutrients (Gadaga et al., 1999;Man & Xiang, 2021). A wide range of

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P1250 Infiuence of Lactobacilli probiotic strains on apoptosis of colon cancer cells lines

Cited by 9 publications

References 0 publications

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Probiotic potential of lactic acid bacteria isolated from fermented dairy milks on antiproliferation of colon cancer cells

Nutritional and ethnomedicinal scenario of koumiss: A concurrent review

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