“…Although it has been suggested that MSCs home to sites of inflammation, it is unknown how many cells will eventually reach the intestine in patients with Crohn's disease. In a case report, Dinesen et al 20 showed that administration of MSCs via selective mesenteric artery cannulation was safe and feasible. This approach may possibly increase the number of cells reaching the affected organ.…”
Administration of autologous bone marrow derived MSCs appears safe and feasible in the treatment of refractory Crohn's disease. No serious adverse events were detected during bone marrow harvesting and administration.
“…Although it has been suggested that MSCs home to sites of inflammation, it is unknown how many cells will eventually reach the intestine in patients with Crohn's disease. In a case report, Dinesen et al 20 showed that administration of MSCs via selective mesenteric artery cannulation was safe and feasible. This approach may possibly increase the number of cells reaching the affected organ.…”
Administration of autologous bone marrow derived MSCs appears safe and feasible in the treatment of refractory Crohn's disease. No serious adverse events were detected during bone marrow harvesting and administration.
“…This group injected haploidentical MSCs after catheterization of the mesenteric artery via the femoral route in a 35-years-old patient with severe refractory fistulizing CD failing all conventional therapies, biological therapies, and surgical ileostomy. The treatment led to a reduction in CDAI but only slight changes in MRI-imaging of fistulous tracts were detected [114].…”
Section: Unanswered Questions and Future Perspectivesmentioning
“…However, it is known that many MSCs are stopped in the lungs, and the proportion of MSCs reaching the inflamed intestine has not been evaluated. Infusion of MSCs via the mesenteric artery may increase the amount of MSCs reaching the inflamed organ and has been successfully performed in one patient without any complication . However, this route of administration is clearly more invasive, and its interest appears minimal as intravenous infusion seems efficient.…”
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