P1‐450: Effects of Docosahexaenoic Acid in a Prodromal Alzheimer's Subgroup of MIDAS

Screening for Cognitive Impairment in Older Adults

“…Twenty-nine RCTs (n = 6489; mean age, 75 years) evaluated other medications or supplements, including antihypertensives, 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (atorvastatin and simvastatin), nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen, indomethacin, and celecoxib), gonadal steroids (estrogen [plus or minus progesterone] and testosterone), and dietary supplements and vitamins (multivitamins, B vitamins, vitamin E, and omega-3 fatty acids). 78,79,114,120,121,127,132,138,155,156,182,195,210,213,223,226,227,234,247,248,[254][255][256]258,260,264,277,285,300 There was no consistent benefit on global cognition or physical function in people with mild to moderate dementia or MCI for any of these medications or supplements (eTable 6 in the Supplement).…”

“…Twenty-one of the RCTs (n = 5688) reported on harms, with harms not significantly increased in intervention groups compared with control groups. 78,79,120,121,127,132,155,195,210,213,223,226,234,247,[254][255][256]258,264,277,300 Nonpharmacologic Patient-Level Interventions Little harm was evident in the few studies (12 RCTs, n = 2370) that reported harms. 119,123,135,162,175,187,188,197,212,229,263,270 Caregiver or Caregiver-Patient Dyad Interventions…”

Fizinio aktyvumo, medikamentinio gydymo, maisto papildų bei kognityvinių treniruočių įtaka Alzheimerio ligos bei susijusių demencijų prevencijai ir kognityvinių gebėjimų išlaikymui

“…Pre pa ra tai var to ti nuo 6 më -ne siø iki 6 me tø. Vie na me ið ty ri mø kaip pa pil das bu vo skiria ma do ko za hek sa e no rûgð tis (DHR) [42], li ku siuo se ðe -ðiuo se ty ri muo se pa pil das bu vo su da ry tas kom bi nuo jant ei ko za pen ta e no rûgð tá (EPR) su DHR. Ben dra vi sø sep tyniø ty ri mø ið va da -ne ras ta pa kan ka mai sva riø áro dy mø, ro dan èiø tei gia mà ome ga-3 rie ba lø rûgð èiø áta kà da ly viø kog ni ty vi niams ge bë ji mams.…”

“…Sta tis tið kai reikð min gø skirtu mø kog ni ty vi niø tes tø re zul ta tuo se tarp abie jø gru piø neras ta, o ið ben drai at lik tø 67 tes tø (9 trum pi kog ni ty vi niai tes tai; 1 neu rop si cho lo gi nis tes tas; 32 tes tai, tik ri nan tys dë -me sio su tel ki mà ir in for ma ci jos ver ti ni mo grei tá; 25 at minties tes tai) tik 5 tes tai ro dë daug ge res ná re zul ta tà, ly gi nant EPR ir DHR pa pil dus var to ju sias gru pes su pla ce bo gru pë -mis. Ta èiau tei gia mi re zul ta tai gau ti ið dvie jø ty ri mø, ku rie bu vo vie ni trum piau siø ir ku riø da ly viai su da rë apie 5 % nuo vi sø mi në tø 7 ty ri mø [42,43]. In for ma ci jos apie ga limà pre ven ci ná po vei ká ty ri muo se ne pa teik ta.…”

The effect of omega-3 fatty acid supplementation on weight loss and cognitive function in overweight or obese individuals on weight-loss diet

“…In a study byJohnson et al (84), 4-month supplementation with DHA (800 mg /day) and/or luthein (12 mg /day) had beneficial effects on verbal fluency, memory, and rate of learning in women aged 60-80 years.The effect of DHA supplementation on age related cognitive deterioration is underlined in several studies. Yurko-Mauro et al(85) have studied the effect of 900 mg/day of DHA supplementation for 24 weeks in 485 adults with age-related cognitive decline, aged over 55 years. They found that DHA supplementation improved immediate and delayed verbal and episodic memory, and learning functions in healthy adults with age-related cognitive decline.…”